| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Human pathogen Aspergillus fumigatus spreads their spores in the air, and infects host mainly from the respiratory system. Increased inflection cases by the fungi are brought by increases of immunocompromised patients caused by, e.g., AIDS, cancer, diabetes, as well as by increase of elderly people in recent years. For the purpose of exploring infection mechanisms and pathogenic factors involved, we made several gene disruption mutants of A. fumigatus strain. Among the mutants, Af2g12180 deficient mutant showed significantly enhanced pathogenicity in mouse infection model. In mice infected with Af2g12180 deficient mutant, liver expression of TLR4, TLR5, Dectin1, CARD9, CCL5, CCL19 mouse genes were significantly suppressed in comparison to mice infected with wild-type A, fumigatus strain. The results suggest Af2g12180 deficient mutant enhanced its pathogenicity by avoiding innate immunity of host.
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