Identification of cytotoxic T lymphocyte responses to lipopeptides in human immunodeficiency virus-infected patients.
| Project/Area Number |
24659481
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Infectious disease medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAORI Akifumi 京都大学, 医学研究科, 教授 (20324626)
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| Project Period (FY) |
2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | エイズ / リポペプチド / キラーT細胞 |
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| Research Abstract |
A new pathway for host defense has recently been identified in the monkey model of AIDS, in which lipopeptide-specific cytotoxic T lymphocytes expand and combat against infection. However, it remains to be determined whether such T cell responses may exist in humans. In this study, we found for the first time that lipopeptide-specific T cells existed in the circulation of a fraction of human immunodeficiency virus-infected patients, capable of producing interferon-gamma, one of the major host-protective factors.
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Report
(2 results)
Research Products
(5 results)
