| Project/Area Number |
24659487
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Tohoku University |
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Principal Investigator |
ISHII Naoto 東北大学, 医学(系)研究科(研究院), 教授 (60291267)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 白血病 / ヒト化マウス / 動物モデル / 白血病モデル / MLLキメラ遺伝子 |
|---|
| Research Abstract |
In vivo studies in which primary human leukemia cells were transplanted into immunodeficient mice, provided significant advances in our understanding of the pathogenesis of human leukemia. However, these models, in which the leukemia cells had already developed in human patients before being transplanted into mice, are not suitable for studying physiological leukemogenesis. Therefore, we here developed a new experimental model for analyzing leukemogenesis in which primary human HSCs are converted into leukemia cells by deliberate genetic hits. We hope that this newly established model using humanized mice will contribute to future studies aimed at revealing the molecular mechanisms for leukemogenesis and developing new therapies against leukemia.
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