| Project/Area Number |
24659489
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
EBIHARA Yasuhiro 東京大学, 医科学研究所, 助教 (40302608)
MOCHIZUKI Shinji 東京大学, 医科学研究所, 特任助教 (90349473)
OHTSU Makoto 東京大学, 医科学研究所, 特任准教授 (30361330)
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| Project Period (FY) |
2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 小児血液学 / iPS細胞 / 先天性骨髄不全症候群 / 白血病 |
|---|
| Research Abstract |
We established iPS cells from somatic cells of a patient with severe congenital neutropenia (SCN), one of congenital bone marrow failure syndrome (SCN-iPS cells). Myeloid cells derived from SCN-iPS cells revealed the maturation arrest at a promyelocyte stage, reflecting the symptom of SCN patients. The gene expression analysis-catenin pathway-related genes, and exogenous Wnt3a induced the improvement in the maturation arrest of SCN-iPS cell-derived myeloid cells. These results indicated the involvement of -catenin pathway in the maturation arrest of myeloid cells in SCN patients and the possibility of novel therapies by activating the pathway. In addition, SCN-iPS cells were expected to be useful for the investigation into the mechanisms causing the occurrence of leukemia and the establishment of the methods to prevent it in SCN.
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