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Cell therapy against intractable EB virus infection using immunological tolerance

Research Project

Project/Area Number 24659493
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionNagoya University

Principal Investigator

KIMURA Hiroshi  名古屋大学, 医学(系)研究科(研究院), 教授 (30303621)

Co-Investigator(Kenkyū-buntansha) GOSHIMA Fumi  名古屋大学, 大学院医学系研究科, 助教 (70201499)
KAMAKURA Maki  名古屋大学, 大学院医学系研究科, COE特任助教 (80437003)
ITO Yoshinori  名古屋大学, 医学部附属病院, 講師 (20373491)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords細胞療法 / 慢性活動性EBV感染症 / 母子間マイクロキメリズム / 免疫寛容 / EBウイルス / 母子間マイクロキメリズム
Research Abstract

Severe Epstein-Barr virus (EBV) infections, such as chronic active EBV infection and EBV-associated hemophagocytic lymphohistiocytosis, are refractory to therapies and intractable diseases. Recently, fetal-maternal lymphohematopoietic microchimerism can be detected in blood from healthy individuals, and immunological tolerance exists between mothers and children. In this study, in order to develop novel therapies for severe EBV infections, fundamental studies including the proof of fetomaternal microchimerism have been performed for establishing cell therapy.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (25 results)

All 2014 2013 2012

All Journal Article (16 results) (of which Peer Reviewed: 14 results) Presentation (8 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Rare occurrence of JAK3 mutations in NK cell neoplasms in Japan2014

    • Author(s)
      Kimura H, Karube K, Ito Y, Hirano K, Suzuki M, Iwata S, Seto M.
    • Journal Title

      Leukemia & Lymphoma

      Volume: 55 Issue: 4 Pages: 962-3

    • DOI

      10.3109/10428194.2013.819577

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Current studies on chronic active Epstein-Barr virus infection in Japan.2014

    • Author(s)
      Fujiwara S, Kimura H, Imadome K, Arai A, Kodama, E, Morio T, Shimizu N, and Wakiguchi H.
    • Journal Title

      Pediatr Int.

      Volume: 56 Issue: 2 Pages: 159-166

    • DOI

      10.1111/ped.12314

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A monoclonal expansion of Epstein–Barr virus-infected natural killer cells after allogeneic peripheral blood stem cell transplantation2013

    • Author(s)
      Isobe Y, Hamano Y, Ito Y, Kimura H, Tsukada N, Sugimoto K, Komatsu N.
    • Journal Title

      J Clin Virol

      Volume: 56 Pages: 150-2

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-17A-Producing T Lymphocytes in Chronic Active Epstein-Barr Virus Infection.2013

    • Author(s)
      Ohta R
    • Journal Title

      Microbiology and Immunology

      Volume: 57 Issue: 2 Pages: 139-144

    • DOI

      10.1111/1348-0421.12010

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plasma Viral MicroRNA Profiles Reveal Potential Biomarkers for Chronic Active Epstein-Barr Virus Infection2013

    • Author(s)
      Kawano Y, Iwata S, Kawada J, Gotoh K, Suzuki M, Torii Y, Kojima S, Kimura H, Ito Y.
    • Journal Title

      J Infect Dis

      Volume: 208(5) Issue: 5 Pages: 771-779

    • DOI

      10.1093/infdis/jit222

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heat shock protein 90 inhibitors repress latent membrane protein 1 (LMP1) expression and proliferation of Epstein-Barr virus-positive natural killer cell lymphoma2013

    • Author(s)
      Murata T, Iwata S, Siddiquey NA, Kanazawa T, Goshima F, Kimura H, Tsurumi T.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 5 Pages: e63566-e63566

    • DOI

      10.1371/journal.pone.0063566

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epstein-Barr virus-positive cytotoxic T-cell lymphoma followed by chronic active Epstein-Barr virus infection-associated T/NK-cell lymphoproliferative disorder: a case report2013

    • Author(s)
      Kato S, Miyata T, Takata K, Shimada S, Ito Y, Tomita A, Elsayed A, Takahashi E, Asano N, Kinoshita T, Kimura H, Nakamura S.
    • Journal Title

      Human Pathology

      Volume: 44 Issue: 12 Pages: 2849-2852

    • DOI

      10.1016/j.humpath.2013.05.025

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epstein-Barr virus-associated lymphoid malignancies : the expanding spectrum of hematopoietic neoplasms2013

    • Author(s)
      Kimura H, Kawda J, Ito Y.
    • Journal Title

      Nagoya J Med Sci

      Volume: 75 Pages: 169-79

    • NAID

      120005322397

    • URL

      http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7534/02_Kimura.pdf

    • Related Report
      2013 Final Research Report
  • [Journal Article] Epstein-Barr virus-associated lymphoid malignancies: the expanding spectrum of hematopoietic neoplasms.2013

    • Author(s)
      Kimura H, Kawda J, Ito Y.
    • Journal Title

      Nagoya Journal of Medical Sciences

      Volume: 75 Pages: 169-179

    • NAID

      120005322397

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Demonstration of type II latency in T lymphocytes of Epstein-Barr Virus-associated hemophagocytic lymphohistiocytosis.2012

    • Author(s)
      Ito Y, Kawamura Y, Iwata S, Kawada J. Yoshikawa T, Kimura H.
    • Journal Title

      Pediatric Blood & Cancer

      Volume: on lineのみ Issue: 2 Pages: 326-328

    • DOI

      10.1002/pbc.24319

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Antitumor activities of valproic acid on Epstein-Barr virus-associated T and natural killer lymphoma cells2012

    • Author(s)
      Iwata, S. Saito, T. Ito, Y. Kamakura, M. Gotoh, K. Kawada, J. Nishiyama, Y. Kimura, H.
    • Journal Title

      Cancer science

      Volume: 103 Issue: 2 Pages: 375-81

    • DOI

      10.1111/j.1349-7006.2011.02127.x

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] EBV-associated T/NK-cell lymphoproliferative diseases in nonimmunocompromised hosts: prospective analysis of 108 cases2012

    • Author(s)
      Kimura H
    • Journal Title

      Blood

      Volume: 119 Issue: 3 Pages: 673-686

    • DOI

      10.1182/blood-2011-10-381921

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hydroa vacciniforme is associated with increased numbers of Epstein-Barrvirus-infected γδT-cells2012

    • Author(s)
      Hirai Y, et al
    • Journal Title

      Journal of Investigative Dermatology

      Volume: 132 Issue: 5 Pages: 1401-1408

    • DOI

      10.1038/jid.2011.461

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] T/NK cell type chronic active Epstein-Barr virus disease in adults : an underlying condition for Epstein-Barr virus-associated T/NK-cell lymphoma2012

    • Author(s)
      Isobe Y, Aritaka N, Setoguchi Y, Ito Y, Kimura H, Hamano Y, Sugimoto K, Komatsu N
    • Journal Title

      J Clin Pathol

      Volume: 65(3) Issue: 3 Pages: 278-282

    • DOI

      10.1136/jclinpath-2011-200523

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Application of flow cytometric in situ hybridization assay to Epstein-Barr virus-associated T/natural killer cell lymphoproliferative2012

    • Author(s)
      Kawabe S, Ito Y, Gotoh K, Kojima S, Matsumoto K, Kinoshita T, Iwata S, Nishiyama Y, Kimura, H,
    • Journal Title

      Cancer Sci

      Volume: 103 Issue: 8 Pages: 1481-1488

    • DOI

      10.1111/j.1349-7006.2012.02305.x

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] EBV-associated T and NK cell lymphoproliferative disorders : Consensus report of the 4th Asian Hematopathology Workshop2012

    • Author(s)
      Ko Y-H, Kim H-J, Oh Y-H, Park G, Lee S-S, Huh J, Kim C-W, Kim I, Ng S-B, Tan S-Y, Chuang S-S, Nakamura N, Yoshino T, Nakamura S, Kimura H, Ohshima K.
    • Journal Title

      J Hematopathol

      Volume: 5 Pages: 319-324

    • URL

      http://link.springer.com/article/10.1007/s12308-012-0169-1/fulltext.html

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Circulating Viral MicroRNAs Are Potential Biomarkers for Disease Status in Chronic Active Epstein-Barr Virus Infection2013

    • Author(s)
      Kawano Y, Iwata S, Kawada JI, Gotoh K, Suzuki M, Torii Y, Kimura H, Ito Y.
    • Organizer
      The 38th International Herpesvirus Workshop
    • Place of Presentation
      Grand Rapids, USA
    • Year and Date
      2013-07-22
    • Related Report
      2013 Final Research Report
  • [Presentation] mTOR inhibitors induce cell cycle arrest and inhibit tumor growth in Epstein-Barr virus-associated T and natural killer cell lymphoma2013

    • Author(s)
      Kawada JI, Ito Y, Iwata S, Kawano Y, Kanazawa T, Siddiquey MN, and Kimura H.
    • Organizer
      The 38th International Herpesvirus Workshop
    • Place of Presentation
      Grand Rapids, USA
    • Year and Date
      2013-07-22
    • Related Report
      2013 Final Research Report
  • [Presentation] EBV感染症の病態と診断2013

    • Author(s)
      木村宏
    • Organizer
      EBウイルス感染症研究会レクチャー
    • Place of Presentation
      ベルサール八重洲、東京都中央区
    • Year and Date
      2013-03-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 難治性EBウイルス感染症~EBV-HLHとCAEBVの病態から治療まで~ : CAEBV~アジア型と欧米型~2012

    • Author(s)
      木村宏
    • Organizer
      第44回日本小児感染症学会学術集会ワークショップ
    • Place of Presentation
      西日本総合展示場/北九州国際会議場、北九州市
    • Year and Date
      2012-11-24
    • Related Report
      2013 Final Research Report
  • [Presentation] EBVと血液・腫瘍性疾患2012

    • Author(s)
      木村宏
    • Organizer
      第74回日本血液学会学術集会教育講演
    • Place of Presentation
      国立京都国際会館、京都市
    • Year and Date
      2012-10-21
    • Related Report
      2013 Final Research Report
  • [Presentation] CAEBV診療の問題点 : 今、求められている研究とは?2012

    • Author(s)
      木村宏
    • Organizer
      第3回CAEBV患者交流会
    • Place of Presentation
      京都祇園ホテル、京都市
    • Year and Date
      2012-10-20
    • Related Report
      2013 Final Research Report
  • [Presentation] ウイルス学の基礎よりみた臓器移植後の感染症2012

    • Author(s)
      木村宏
    • Organizer
      第48回日本移植学会総会、教育セミナー
    • Place of Presentation
      愛知県産業労働センター、名古屋市
    • Year and Date
      2012-09-22
    • Related Report
      2013 Final Research Report
  • [Presentation] Chronic active Epstein-Barr virus infection and related diseases in Japan2012

    • Author(s)
      Kimura H.
    • Organizer
      Asian Hematopathology Symposium
    • Place of Presentation
      Soul, Korea
    • Year and Date
      2012-01-29
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] ウイルス感染細胞の検出・同定法及びキット2013

    • Inventor(s)
      木村 宏、西山幸廣
    • Industrial Property Rights Holder
      国立大学法人名古屋大学
    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2013-12-13
    • Related Report
      2013 Final Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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