| Project/Area Number |
24659497
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Osaka University |
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Principal Investigator |
TANIIKE MASAKO 大阪大学, 連合小児発達学研究科, 教授 (30263289)
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| Co-Investigator(Kenkyū-buntansha) |
MOHRI Ikuko 大阪大学, 大学院連合小児発達学研究科, 准教授 (70399351)
SHIMONO Kuriko 大阪大学, 大学院連合小児発達学研究科, 講師 (60403185)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | オキシトシン / 自閉症スペクトラム障害 / 臨床研究 / 対人応答性尺度 / 子どもの行動チェックリスト / 視線計測 / ADOS-G |
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| Outline of Final Research Achievements |
We administered oxytocin to boys with autism spectrum disorders whose IQ were between 35 and 75 via nasal spray once daily for consecutive 1 month. We analyzed the data of 11 boys who completed the study and found out the urine level of oxytocin was elevated compared with that in the placebo period, indicating the good compliance and optimal absorption and excretion. However, evaluation based on caregivers' observation disclosed no significant effects on social dysfunction, restricted and repetitive behaviors, and problematic behaviors. On the other hand, serious adverse events have not recognized in all cases, while one boy discontinued the study because he was intolerable to the nasal spray. Our results are disappointing, however, the efficacy of the intranasal spray of oxytocin is still an issue of controversy.
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