Efficacy of the intranasal oxytocin spray in the treament of the autism spectrum disorder
| Project/Area Number |
24659497
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Osaka University |
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Principal Investigator |
TANIIKE MASAKO 大阪大学, 連合小児発達学研究科, 教授 (30263289)
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| Co-Investigator(Kenkyū-buntansha) |
MOHRI Ikuko 大阪大学, 大学院連合小児発達学研究科, 准教授 (70399351)
SHIMONO Kuriko 大阪大学, 大学院連合小児発達学研究科, 講師 (60403185)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | オキシトシン / 自閉症スペクトラム障害 / 臨床研究 / 対人応答性尺度 / 子どもの行動チェックリスト / 視線計測 / ADOS-G |
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| Outline of Final Research Achievements |
We administered oxytocin to boys with autism spectrum disorders whose IQ were between 35 and 75 via nasal spray once daily for consecutive 1 month. We analyzed the data of 11 boys who completed the study and found out the urine level of oxytocin was elevated compared with that in the placebo period, indicating the good compliance and optimal absorption and excretion. However, evaluation based on caregivers' observation disclosed no significant effects on social dysfunction, restricted and repetitive behaviors, and problematic behaviors. On the other hand, serious adverse events have not recognized in all cases, while one boy discontinued the study because he was intolerable to the nasal spray. Our results are disappointing, however, the efficacy of the intranasal spray of oxytocin is still an issue of controversy.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Atomoxetine reverses locomotor hyperactivity, impaired novel object recognition, and prepulse inhibition impairment in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP).2015
Author(s)
hibasaki Y, Hayata-Takano A, Hazama K, Nakazawa T, Shintani N, Kasai A, Nagayasu K, Hashimoto R, Tanida M, Katayama T, Matsuzaki S, Yamada K, Taniike M, Onaka Y, Ago Y, Waschek JA, Köves K, Reglődi D, Tamas A, Matsuda T, Baba A, Hashimoto H.
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Journal Title
Neuroscience
Volume: 297
Pages: 95-104
DOI
Related Report
Peer Reviewed
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[Journal Article] Duplication of the NPHP1 gene in patients with autism spectrum disorder and normal intellectual ability: a case series.2014
Author(s)
Yasuda Y, Hashimoto R, Fukai R, Okamoto N, Hiraki Y, Yamamori H, Fujimoto M, Ohi K, Taniike M, Mohri I, Nakashima M, Tsurusaki Y, Saitsu H, Matsumoto N, Miyake N, Takeda M.
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Journal Title
Ann Gen Psychiatry.
Volume: 13
Issue: 1
Pages: 22-26
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A case of cerebral hypomyelination with spondylo-epi-metaphyseal dysplasia.2013
Author(s)
97. Kimura-Ohba S, Kagitani-Shimono K, Hashimoto N, Nabatame S, Okinaga T,Murakami A, Miyake N, Matsumoto N, Osaka H, Hojo K, Tomita R, Taniike M, Ozono K.
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Journal Title
Am J Med Genet A.
Volume: 161
Issue: 1
Pages: 203-7
DOI
Related Report
Peer Reviewed
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[Presentation] Differential responses of mismatch field in autistic spectrum disorder with auditory hypersensitivity: a MEG study.2013
Author(s)
Matsuzaki J, Kagitani-Shimono K, Sugata H, Hirata M, Hirata I, Hanaie R, Nagatani F, Tachibana M, Tominaga T, Mohri I, Taniike M.
Organizer
SFN2013, San Diego, USA
Place of Presentation
San Diego, USA
Related Report
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[Presentation] Abnormalities of the corpus callosum connectivity are related to the severity of core features, but not to motor dysfunction in children with autistic spectrum disorders2013
Author(s)
R. HANAIE, I. MOHRI, K. KAGITANI-SHIMONO, M. TACHIBANA, I. HIRATA, J. MATSUZAKI, M. TANIIKE
Organizer
SFN2013, San Diego, USA
Place of Presentation
San Diego, USA
Related Report
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[Presentation] Differential response to aversion sound in autisti spectrum disorder with auditory hypersensitivity: a MEG study.2013
Author(s)
Kagitani-Shimono K, Matsuzaki J, Sugata H, Hirata M, Hirata I, Hanaie R, Nagatani F, Tachibana M, Tominaga K, Mohri I, Taniike M.
Organizer
International Society for the Advancement of Clinical Magnetoencephalography meeting 2013
Place of Presentation
Sapporo
Related Report
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