Post-ischemic reperfusion injury inhibiting effect of the new compound dichloroacetylcarnitine
Project/Area Number |
24659501
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Pediatrics
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Research Institution | Kyoto Prefectural University of Medicine |
Principal Investigator |
ITOI TOSHIYUKI 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (10264780)
|
Co-Investigator(Kenkyū-buntansha) |
TOIYAMA Kentaro 京都府立医科大学, 大学院医学研究科, 助教 (00433285)
OKA Tatsujiro 京都府立医科大学, 大学院医学研究科, 研究員 (80433283)
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Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
|
Keywords | 再灌流障害 / ジクロル酢酸 / カルニチン / 新化合物 / 心筋 / dichloroacetate / carnitine / reperfusion injury / myocardium |
Outline of Final Research Achievements |
Our aim of this study was to synthesize new low-molecular compound which has pharmacological effects of both dichloroacetate and acetyl-carnitine and to analyze its effect of organ protection. We synthesized basic molecular platform in 2012 and succeeded to produce new compound A which was induced biological equivalent substituent during 2013-2014. The functional recovery rate of reperfused rat heart under isolated heart perfusion system was significantly high of 73±38% in compound A group in comparison with the control group of 14±6%. The structure of the new compound was concealed because this was under pending patent application.
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Report
(4 results)
Research Products
(1 results)