Taurine abnormality may underlie developmental disorders via perturbation of multimodal GABA actions

• Project/Area Number: 24659508
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: FUKUDA Atsuo 浜松医科大学, 医学部, 教授 (50254272)
• Co-Investigator(Renkei-kenkyūsha): HATA Kenichiro 国立成育医療研究センター, 部長 (60360335) ; KUMADA Tatsuro 常葉大学, 保健医療学部, 教授 (00402339)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: クロライドホメオダイナミクス / 大脳皮質 / 発達障害 / 皮質板細胞 / GABA / タウリン / タウリントランスポーター / 細胞移動 / 生理学 / 神経科学 / 発生・分化 / KCC2 / トニックカレント

Research Abstract

In immature neurons, intracellular Cl- concentration is high due to balance of Cl- transporters, promoting depolarizing GABA action by efflux of Cl- along with its electrical gradient. These GABAA receptor-mediated actions are excitatory and/or non-synaptic tonic depolarization in immature brain. These GABAA receptor activation are necessary for neurogenesis, differentiation, migration, and synaptogenesis of developing brain. Therfore, perturbation of the multimodal GABA actions may underlie fetal and neonatal brain disorders. By hypothesizing fetal taurine of maternal origin as an endogenous agonist of fetal GABAA receptor, we have studied how taurine interact with development and pathogenesis of fetal cortex.

Research Products

• [Journal Article] Activity-dependent endogenous taurine release facilitates excitatory neurotransmission in the neocortical marginal zone of neonatal rats. (2014)
  • Author(s): Qian, T., et al.,
  • Journal Title: Front Cell Neurosci. Volume: 8 Pages: 33-33
  • DOI: 10.3389/fncel.2014.00033
  • Peer Reviewed / Open Access
• [Journal Article] 胎児脳発達における母体ストレスの影響 : 特に抑制性神経との関係について (2014)
  • Author(s): 福田敦夫
  • Journal Title: ベビーサイエンス Volume: 13 Pages: 2-24
  • NAID: 40020157534
• [Journal Article] 胎児脳発達における母体ストレスの影響：特に抑制性神経との関係について. (2014)
  • Author(s): 福田敦夫.
  • Journal Title: ベビーサイエンス Volume: 13 Pages: 2-24
  • NAID: 40020157534
• [Journal Article] Accumulation of GABAergic neurons, causing a focal ambient GABA gradient, and downregulation of KCC2 are induced during microgyrus formation in a mouse model of polymicrogyria. (2013)
  • Author(s): Wang T, Kumada T, Morishima T, Kaneko T, Yanagawa Y, Yoshida S, Fukuda A
  • Journal Title: Cerebral Cortex Volume: in press Issue: 4 Pages: 1088-1101
  • DOI: 10.1093/cercor/bhs375
  • Peer Reviewed
• [Journal Article] De Novo Mutations in GNAO1, Encoding a Gαo Subunit of Heterotrimeric G Proteins, Cause Epileptic Encephalopathy. (2013)
  • Author(s): Nakamura, K., et al.,
  • Journal Title: Am. J. Hum. Genet. Volume: 93 Issue: 3 Pages: 496-505
  • DOI: 10.1016/j.ajhg.2013.07.014
  • Peer Reviewed
• [Journal Article] Cl- homeodynamics in gap-junction-coupled astrocytic networks on activation of GABAergic synapses. (2013)
  • Author(s): Egawa K., Yamada J., Furukawa T., Yanagawa Y., Fukuda A
  • Journal Title: The Journal of physiology Volume: 591 Issue: 16 Pages: 3901-3917
  • DOI: 10.1113/jphysiol.2013.257162
  • Peer Reviewed
• [Journal Article] Modulation of allopregnanolone on excitatory transmitters release from single glutamatergic terminal (2013)
  • Author(s): Iwata, S., Wakita, M., Shin, M., Fukuda, A. and Akaike, N.
  • Journal Title: Brain Research Bulletin Volume: 93 Pages: 39-46
  • DOI: 10.1016/j.brainresbull.2012.11.002
  • Peer Reviewed
• [Journal Article] Pathophysiological power of improper tonic GABAA conductances in mature and immature models. (2013)
  • Author(s): Egawa, K. and Fukuda, A.
  • Journal Title: Frontiers in Neural Circuits Volume: 7 Pages: 170-170
  • DOI: 10.3389/fncir.2013.00170
  • Peer Reviewed
• [Journal Article] A perturbation of multimodal GABA functions underlying the formation of focal cortical malformations : assessments by using animal models (2013)
  • Author(s): Fukuda, A. and Wang, T.
  • Journal Title: Neuropathology Volume: 33 Issue: 4 Pages: 480-486
  • DOI: 10.1111/neup.12021
  • Peer Reviewed
• [Journal Article] アンジェルマン症候群の運動障害と小脳での持続性抑制の低下 (2013)
  • Author(s): 江川潔,福田敦夫
  • Journal Title: 実験医学 Volume: 31 (6) Pages: 914-917
• [Journal Article] アンジェルマン症候群の運動障害と小脳での持続性抑制の低下. (2013)
  • Author(s): 江川 潔、福田敦夫.
  • Journal Title: 実験医学 Volume: 31 Pages: 914-917
• [Journal Article] Pre- and post-synaptic switches of GABA actions associated with Cl - homeostatic changes are induced in the spinal nucleus of the trigeminal nerve in a rat model of trigeminal neuropathic pain. (2012)
  • Author(s): Wei, B., et al,
  • Journal Title: Neuroscience Volume: 228 Pages: 334-348
  • DOI: 10.1016/j.neuroscience.2012.10.043
  • Peer Reviewed
• [Journal Article] Decreased tonic inhibition in cerebellar granule cells causes motor dysfunction in a mouse model of Angelman syndrome. (2012)
  • Author(s): Egawa, K., et al.
  • Journal Title: Sci. Transl. Med. Volume: 4 Issue: 163
  • DOI: 10.1126/scitranslmed.3004655
  • Peer Reviewed
• [Journal Article] Refuting the challenges of the developmental shift of polarity of GABA actions : GABA more exciting than ever! (2012)
  • Author(s): Ben-Ari, Y., Woodin, M.A., Sernagor, E., Cancedda, L., Vinay, L., Rivera, C., Legendre, P., Luhmann, H.J., Bordey, A., Wenner, P., Fukuda, A., vad den Pol, A.N., Gaiarsa, J.L. and Cherubini, E.
  • Journal Title: Frontiers in Cellular Neuroscience Volume: 6 Pages: 1-18
  • DOI: 10.3389/fncel.2012.00035
  • Peer Reviewed
• [Journal Article] GABAの抑制と興奮の二面性 (2012)
  • Author(s): 福田敦夫
  • Journal Title: Epilepsy Volume: 6 Pages: 85-92
  • NAID: 40019478063
• [Journal Article] GABAのマルチモーダルな作用 (2012)
  • Author(s): 福田敦夫
  • Journal Title: Clinical Neuroscience Volume: 30 (12) Pages: 1355-1359
• [Journal Article] GABA,グリシンの機能-脊髄での機能を中心に (2012)
  • Author(s): 福田敦夫
  • Journal Title: Clinical Neuroscience Volume: 30 (7) Pages: 795-798
• [Journal Article] Phosphodiesterase 4 inhibition enhances the dopamine D1receptor/PKA/D ARPP-32 signaling cascade in frontal cortex (2012)
  • Author(s): Kuroiwa, M., et al
  • Journal Title: Psychopharmacology Volume: 219 Issue: 4 Pages: 1065-1079
  • DOI: 10.1007/s00213-011-2436-8
  • Peer Reviewed
• [Journal Article] Taurine inhibits the K+-Cl- cotransporter KCC2 to regulate embryonic Cl- homeostasis via the with-no-lysine (WNK) protein kinase signaling pathway. (2012)
  • Author(s): Inoue, K., Furukawa, T., Kumada, T., Yamada, J., Wang, T., Inoue, R. and Fukuda A.
  • Journal Title: The Journal of Biological Chemistry Volume: 287 Pages: 20839-20850
  • Peer Reviewed
• [Journal Article] Decreased tonic inhibition in cerebellar granule cells causes motor dysfunction in a mouse model of Angelman syndrome. (2012)
  • Author(s): Egawa, K., Kitagawa, K., Inoue, K., Takayama, M., Takayama, C., Saitoh, S., Kishino, T., Kitagawa, M., and Fukuda, A.
  • Journal Title: Science Translational Medicine Volume: 4
  • Peer Reviewed
• [Journal Article] Guidepost Neurons for the Lateral Olfactory Tract: Expression of Metabotropic Glutamate Receptor 1 and Innervation by Glutamatergic Olfactory Bulb Axons. (2012)
  • Author(s): Hirata, T., Kumada, T., Kawasaki, T., Furukawa, T., Aiba, A. Conquet, F., Saga, Y., and Fukuda, A.
  • Journal Title: Developmental Neurobiology Volume: 72 Pages: 1559-1576
  • Peer Reviewed
• [Journal Article] GABAのマルチモーダルな作用. (2012)
  • Author(s): 福田敦夫.
  • Journal Title: Clinical Neuroscience Volume: 30 Pages: 1355-1359
• [Journal Article] GABAの抑制と興奮の二面性 (2012)
  • Author(s): 福田敦夫
  • Journal Title: Epilepsia Volume: 6 Pages: 85-92
  • NAID: 40019478063
• [Journal Article] GABA，グリシンの機能-脊髄での機能を中心に. (2012)
  • Author(s): 福田敦夫.
  • Journal Title: Clinical Neuroscience Volume: 30 Pages: 795-798
• [Journal Article] Refuting the challenges of the developmental shift of polarity of GABA actions: GABA more exciting than ever! (2012)
  • Author(s): Ben-Ari, Y., Woodin, M.A., Sernagor, E., Cancedda, L., Vinay, L., Rivera, C., Legendre, P., Luhmann, H.J., Bordey, A., Wenner, P., Fukuda, A., et al.
  • Journal Title: Frontiers in Cellular Neuroscience Volume: 6 Pages: 1-18
• [Presentation] Maternal taurine as a modulator of fetal brain's Cl- homeostasis (2014)
  • Author(s): Fukuda, A.
  • Organizer: 93^<rd> DPG Annual Meeting
  • Place of Presentation: Mainz, Germany
  • Invited
• [Presentation] Exploring the role of anion channels in cell volume regulation and intercellular communications in the developing brain (2014)
  • Author(s): Akita T, Fukuda A.
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島(Symposium)
• [Presentation] Visualization of the glutamate release in the mouse retina (2014)
  • Author(s): Ohkuma, M., Horio, K., Kaneda, M., Yoshida, S., Fukuda, A., Miyachi E.
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島(Symposium)
• [Presentation] Visualization of the glutamate release in the mouse retina. (2014)
  • Author(s): Mahito Ohkuma, Kayo Horio, Makoto Kaneda, Sachiko Yoshida, Atsuo Fukuda, Ei-ichi Miyachi.
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島
• [Presentation] Diminished tonic GABA_A inhibition attributable to decreased GAT1 degradation in cerebellar granule cells in a model of Angelman syndrome (2013)
  • Author(s): Fukuda, A., and Egawa, K.
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都(Symposium)
  • Year and Date: 2013-06-21
• [Presentation] Developmental Cl^- homeodynamics underlying neonatal seizures (2013)
  • Author(s): Fukuda, A.
  • Organizer: 2013 Pediatric Academic Societies (PAS) Annual Meeting
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2013-05-04
  • Invited
• [Presentation] Maternal taurine as a modulator of GABA_A receptor and Cl^- homeostasis during perinatal period (2013)
  • Author(s): Fukuda, A.
  • Organizer: The 15th International Symposium on Neonatal Seizures and Related Disorders (ISNS)
  • Place of Presentation: 東京
  • Year and Date: 2013-04-14
  • Invited
• [Presentation] 大脳皮質の発生過程における移動神経細胞の領域特異的なGABAA受容体応答 (2013)
  • Author(s): 熊田竜郎,中西康彦,古川智範,福田敦夫
  • Organizer: 第40回日本脳科学会
  • Place of Presentation: 浜松(Oral)
• [Presentation] Volume-sensitive outwardly rectifying (VSOR) anion channels in the developing brain (2013)
  • Author(s): Akita T, Fukuda A.
  • Organizer: The 11th Korea-Japan Joint Symposium of Brain Sciences, and Cardiac and Smooth Muscle Sciences
  • Place of Presentation: Hamamatsu, Japan. (Symposium)
• [Presentation] 母体ストレスとGABA合成酵素減少による仔脳の病的所見GAD67遺伝子ヘテロ欠損仔への母体ストレスが生後脳のPV陽性GABA細胞を特異的に減少させる (2013)
  • Author(s): 内田琢,古川智範,岩田暁美,柳川右千夫,福田敦夫
  • Organizer: 日本赤ちゃん学会第13回学術集会
  • Place of Presentation: 福岡(Poster)
• [Presentation] Developmental changes in the respiration-related rhythmic activity in mouse hypoglossal nucleus (2013)
  • Author(s): 岡部明仁,荒田晶子,清水-岡部千草,小西史朗,福田敦夫,高山千利
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都(Poster)
• [Presentation] Taurine is involved in the regulation of the intrinsic properties of the neural progenitors as a possible ligand of GABAA receptors in the mouse developing neocortex (2013)
  • Author(s): 栃谷史郎,古川智範,福田敦夫
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都(Poster)
• [Presentation] Modulation of excitatory action of GABA in GnRH neurons in vivo cause impairment of fertility (2013)
  • Author(s): 渡部美穂、鍋倉淳一、福田敦夫
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都(Poster)
• [Presentation] Welner Kilb, Heiko, J. Luhmann,中原大一郎,福田敦夫. Activity dependent release of taurine facilitates the excitatory neurotransmission in the marginal zone of developing cerebral cortex (2013)
  • Author(s): 熊田竜郎,千太哲,中村直人,古川智範,山田順子,秋田天平
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都(Poster)
• [Presentation] Valproate application to rat fetus changes developing GABA release and neuronal differentiation (2013)
  • Author(s): 吉田祥子,田野崎真,福田敦夫,笛田由紀子,関野祐子
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都(Poster)
• [Presentation] Cl- homeodynamics in astrocytic networks on activation of tripartite GABAergic synapses (2013)
  • Author(s): Fukuda, A., Egawa, K., Yamada, J., Furukawa, T. and Yanagawa, Y.
  • Organizer: Society for Neuroscience 2013
  • Place of Presentation: San Diego, USA(Poster)
• [Presentation] Regional difference in GABA_A Receptor Mediated Ca^<2+> responses of radially migrating neurons in the mouse embryonic neocortex (2013)
  • Author(s): Kumada, T., Nakanishi, Y., Furukawa, T. and Fukuda, A.
  • Organizer: The 23th CDB meeting
  • Place of Presentation: Kobe, Japan(Poster)
• [Presentation] Conditional modulation of excitation action of GABA on GnRH neurons in Vivo causes impairment of migration (2013)
  • Author(s): Watanabe, M., Fukuda, A. and Nabekura, J.
  • Organizer: The 23th CDB meeting
  • Place of Presentation: Kobe, Japan(Poster)
• [Presentation] Amibient GABA regulates the multidirectional tangential migration of GABAergic interneurons in living neonatal mice (2013)
  • Author(s): Inada, H., Watanabe, M., Uchida, T., Fukuda, A., Yanagawa, Y., and Nabekura, J.
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: 東京(Symposium)
• [Presentation] Deteriorated degradation of GAT1 by Ube3a deficiency causes a decrement of tonic inhibition in cerebellar granule cells and a cerebellar ataxia. Ube3a (2013)
  • Author(s): Fukuda, A., Egawa, K., Kitagawa, K., Inoue, K., Takayama, M., Takayama, C., Saitoh, S., Kishino, T., and Kitagawa, M.
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: 東京(Poster)
• [Presentation] Activity-dependent endogenous taurine release facilitates the excitatory neurotransmission in the neocortical marginal zone of neonatal rats (2013)
  • Author(s): Kumada, T., Qian, T., Nakamura, M., Furukawa, T., Kilb, W., Luhmann, H. J., Nakahara, D. and Fukuda, A.
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: 東京(Poster)
• [Presentation] Cl- homeodynamics in astrocytic networks on activation of tripartite GABAergic synapses. (2013)
  • Author(s): Fukuda, A., Egawa, K., Yamada, J., Furukawa, T. and Yanagawa, Y.
  • Organizer: Society for Neuroscience 2013
  • Place of Presentation: San Diego, USA
• [Presentation] 母体ストレスとGABA合成酵素減少による仔脳の病的所見 GAD67遺伝子ヘテロ欠損仔への母体ストレスが生後脳のPV陽性GABA細胞を特異的に減少させる. (2013)
  • Author(s): 内田 琢, 古川智範, 岩田暁美, 柳川右千夫, 福田敦夫.
  • Organizer: 日本赤ちゃん学会第13回学術集会
  • Place of Presentation: 福岡
• [Presentation] Developmental changes in the respiration-related rhythmic activity in mouse hypoglossal nucleus. (2013)
  • Author(s): 岡部明仁, 荒田晶子, 清水-岡部千草, 小西史朗, 福田敦夫, 高山千利.
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都
• [Presentation] Taurine is involved in the regulation of the intrinsic properties of the neural progenitors as a possible ligand of GABAA receptors in the mouse developing neocortex. (2013)
  • Author(s): 栃谷史郎, 古川智範, 福田敦夫.
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都
• [Presentation] Modulation of excitatory action of GABA in GnRH neurons in vivo cause impairment of fertility. (2013)
  • Author(s): 渡部美穂、鍋倉淳一、福田敦夫.
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都
• [Presentation] Activity dependent release of taurine facilitates the excitatory neurotransmission in the marginal zone of developing cerebral cortex. (2013)
  • Author(s): 熊田竜郎, 千 太哲, 中村直人, 古川智範, 山田順子, 秋田天平, Welner Kilb, Heiko, J. Luhmann, 中原大一郎, 福田敦夫.
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都
• [Presentation] Valproate application to rat fetus changes developing GABA release and neuronal differentiation. (2013)
  • Author(s): 吉田祥子, 田野崎真, 福田敦夫, 笛田由紀子, 関野祐子.
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都
• [Presentation] Pre- and post-synaptic switches of GABA actions in the spinal nucleus of the trigeminal nerve in a rat model of trigeminal neuropathic pain (2012)
  • Author(s): Kumada, T., Wei, B., Furukawa, T., Inoue, K., Watanabe, M., Sato, K. and Fukuda, A.
  • Organizer: The 12th Kyungpook-Hamamatsu Joint Medical Symposium Hamamatsu Meeting
  • Place of Presentation: Hamamatsu, Japan(Oral)
  • Year and Date: 2012-09-26
• [Presentation] マウス発生期大脳新皮質においてGABAA受容体を介したシグナルは神経前駆細胞の内在的性質を制御する (2012)
  • Author(s): 栃谷史郎,古川智範,坂東遼,近藤重明,福田敦夫,福井義浩
  • Organizer: 第35回日本分子生物学会
  • Place of Presentation: 福岡(Poster)
• [Presentation] 活動依存的な内因性タウリンの放出が新生ラット大脳新皮質辺縁体の興奮性シナプス伝達を促進する (2012)
  • Author(s): 熊田竜郎,千太哲,中村直人,古川智範, Kilb Werner, Luhmann Heiko J.,中原大一郎,福田敦夫
  • Organizer: 生理学研究所研究会
  • Place of Presentation: 岡崎(Oral)
• [Presentation] 母性Ube3a欠失マウス小脳顆粒細胞におけるGABAトランスポーター過剰によるトニック抑制の減弱と小脳機能障害 (2012)
  • Author(s): 江川潔,北川恭子,井上浩一,高山理和,高山千利,斉藤伸治,木住野達也,北川正敏,福田敦夫
  • Organizer: 第59回中部生理学会
  • Place of Presentation: 岡崎(Oral)
• [Presentation] マウス大脳皮質の移動神経細胞における領域特異的なGABA_A受容体応答 (2012)
  • Author(s): 熊田竜郎,中西康彦,古川智範,江川潔,福田敦夫
  • Organizer: 第59回中部生理学会
  • Place of Presentation: 岡崎(Poster)
• [Presentation] 母体ストレスによるGAD67ヘテロ欠損胎仔でのGABAニューロンの特異的減少 (2012)
  • Author(s): 内田琢,柳川右千夫,福田敦夫
  • Organizer: 第39回日本脳科学会
  • Place of Presentation: 福岡(Oral)
• [Presentation] 皮質形成異常の成因に関与する細胞外GABAと細胞内Cl^- (2012)
  • Author(s): 福田敦夫,王天英,柳川右千夫
  • Organizer: 第39回日本脳科学会
  • Place of Presentation: 福岡(Oral)
• [Presentation] Decrease inγ-tubulin 2 underlies an atypical parkinsonism through the impairment of mitochondrial function in striatal neurons (2012)
  • Author(s): Tsutsumi, K., Kubo, A., Takagi, H., Akatsu, H., Konno, A., Miyamoto, Y., Yao, I., Yamauchi, D., Horio, T., Miyakawa, T., Miyajima, H., Fukuda, A., Tsukada, H., Yoshida, M., Hashizume, Y., Mineyuki,Y., Konishi, Y., Ikegami, K., Tsukita, S. and Setou, M.
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋(Oral)
• [Presentation] Homeostatic Cl^–dynamics at GABAergic synapses in hippocampus promoted by the astrocytic syncytium (2012)
  • Author(s): Fukuda, A., Egawa, K., Yamada, J., Furukawa, T. and Yanagawa, Y.
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋(Poster)
• [Presentation] Regional difference in calcium oscillation of radially migrating neurons in the mouse embryonic neocortex (2012)
  • Author(s): Kumada, T., Nakanishi, Y., Furukawa, T., Egawa, K. and Fukuda, A.
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋(Poster)
• [Presentation] Effects of allopregnanolone on glutamatergic presynaptic nerve terminal (2012)
  • Author(s): Iwata, S., Fukuda, A., Min-Chul Shin, Wakita, M. and Akaike, N.
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋(Poster)
• [Presentation] Visualization of glutamate release in the mouse retinal slice (2012)
  • Author(s): Ohkuma, M., Kaneda, M., Yoshida, S., Fukuda, A., and Miyachi, E.
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋(Poster)
• [Presentation] The adverse effect of GABA overdose in developing rat cerebellar cortex (2012)
  • Author(s): Tanosaki, M., Katsumata, D., Sekino, Y., Fukuda, A. and Yoshida, S.
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋(Poster)
• [Presentation] Transient GABA release from cerebellar glial cells is conditioned by the transporter proteins (2012)
  • Author(s): Yoshida, S., Yamada, H., Kurimoto,Y., Kobayashi, K., Takayama, C., Yamamoto, S., Fukuda, A. and Hozumi, N.
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋(Poster)
• [Presentation] Intracellular taurine inhibits the functioning of KCC2 protein by phosphorylation via with-no-lysine (WNK) protein kinase pathway (2012)
  • Author(s): Fukuda, A., Inoue, K., Furukawa, T., Yamada, J., Kumada, T., Wang, T. and Inoue, R.
  • Organizer: The 8^<th > FENS Forum of Neuroscience
  • Place of Presentation: Barcelona, Spain(Poster)
• [Presentation] Cl^-ホメオダイナミクスによるGABAスイッチと神経オシレーション (2012)
  • Author(s): 福田敦夫
  • Organizer: 神経オシレーション:共振とディスリズミア研究会
  • Place of Presentation: 岡崎(Symposium)
  • Invited
• [Presentation] 動物モデルを用いた皮質形成異常の成因に関するマルチモーダルGABA仮説の検証 (2012)
  • Author(s): 福田敦夫
  • Organizer: 第53回日本神経病理学会総会学術研究会
  • Place of Presentation: 新潟(Symposium) (基調講演)
• [Presentation] Intracellular taurine inhibits the functioning of KCC2 protein by phosphorylation via with-no-lysine (WNK) protein kinase pathway. (2012)
  • Author(s): Fukuda, A., Inoue, K., Furukawa, T., Yamada, J., Kumada, T., Wang, T., and Inoue, R.
  • Organizer: The 8th FENS Forum of Neuroscience
  • Place of Presentation: Barcelona, Spain.
• [Presentation] Cl- ホメオダイナミクスによるGABAスイッチと神経オシレーション. (2012)
  • Author(s): 福田敦夫.
  • Organizer: 神経オシレーション：共振とディスリズミア研究会
  • Place of Presentation: 岡崎
  • Invited
• [Presentation] 動物モデルを用いた皮質形成異常の成因に関するマルチモーダルGABA仮説の検証. (2012)
  • Author(s): 福田敦夫.
  • Organizer: 第53回日本神経病理学会総会学術研究会
  • Place of Presentation: 新潟
  • Invited
• [Presentation] 皮質形成異常の成因に関与する細胞外GABAと細胞内Cl-. (2012)
  • Author(s): 福田敦夫, 王 天英, 柳川右千夫.
  • Organizer: 第39回日本脳科学会
  • Place of Presentation: 福岡
• [Presentation] アストロサイト回路網によってもたらされる海馬GABAシナプスにおけるホメオスタティックなCl-動態. (2012)
  • Author(s): 福田敦夫, 江川 潔, 山田順子,古川智範, 柳川 右千夫.
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] γ-tubulin2の減少は線条体神経細胞のミトコンドリア機能障害を介し非定型パーキンソン病を発症させる. (2012)
  • Author(s): 堤 弘次, 久保亜紀子, 高木博, 赤津裕康, 紺野 在, 宮本裕子, 矢野育子, 山内大輔, 堀尾哲也, 宮川 剛, 宮嶋裕明, 福田敦夫, 他.
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] 母体ストレスによるGAD67ヘテロ欠損胎仔でのGABAニューロンの特異的減少. (2012)
  • Author(s): 内田 琢, 柳川右千夫, 福田敦夫.
  • Organizer: 第39回日本脳科学会
  • Place of Presentation: 福岡
• [Presentation] 母性Ube3a 欠失マウス小脳顆粒細胞におけるGABAトランスポーター過剰によるトニック抑制の減弱と小脳機能障害. (2012)
  • Author(s): 江川 潔, 北川恭子, 井上浩一, 高山理和, 高山千利, 斉藤伸治, 木住野達也, 北川正敏, 福田敦夫.
  • Organizer: 第59回中部生理学会
  • Place of Presentation: 岡崎
• [Presentation] 活動依存的な内因性タウリンの放出が新生ラット大脳新皮質辺縁体の興奮性シナプス伝達を促進する. (2012)
  • Author(s): 熊田竜郎, 千太哲, 中村直人, 古川智範, Kilb Werner, Luhmann Heiko J., 中原大一郎, 福田敦夫.
  • Organizer: 生理学研究所研究会
  • Place of Presentation: 岡崎
• [Presentation] Allopregnanoloneのグルタミン酸作動性神経終末部に対する効果. (2012)
  • Author(s): 岩田暁美, 福田敦夫, 申 敏哲, 脇田真仁, 赤池紀生.
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] マウス網膜スライス標本を用いたグルタミン酸放出レベルの可視化. (2012)
  • Author(s): 大熊真人, 金田 誠, 吉田祥子, 福田敦夫, 宮地栄一.
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] 過剰量のGABAは小脳発達に影響を及ぼす. (2012)
  • Author(s): 田野崎真, 勝股大樹, 関野祐子, 福田敦夫, 吉田祥子.
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] 発達期小脳皮質のグリアからGABA放出はトランスポーターで制御される. (2012)
  • Author(s): 吉田祥子, 山田ひかり, 栗本侑依, 小林和人, 高山千利, 山本清二, 福田敦夫, 穂積直裕.
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] マウス発生期大脳新皮質においてGABAA受容体を介したシグナルは神経前駆細胞の内在的性質を制御する. (2012)
  • Author(s): 栃谷史郎, 古川智範, 坂東 遼, 近藤重明, 福田敦夫, 福井義浩.
  • Organizer: 第35回日本分子生物学会
  • Place of Presentation: 福岡
• [Presentation] マウス大脳皮質の移動神経細胞における領域特異的なGABAA受容体応答. (2012)
  • Author(s): 熊田竜郎, 中西康彦, 古川智範, 江川 潔, 福田敦夫.
  • Organizer: 第59回中部生理学会
  • Place of Presentation: 岡崎
• [Presentation] Maternal taurine as a modulator of fetal brain’s Cl- homeostasis.
  • Author(s): Fukuda, A.
  • Organizer: 93rd DPG Annual Meeting
  • Place of Presentation: Mainz, Germany
  • Invited
• [Presentation] Diminished tonic GABAA inhibition attributable to decreased GAT1 degradation in cerebellar granule cells in a model of Angelman syndrome.
  • Author(s): 福田敦夫, 江川 潔.
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都
• [Presentation] Developmental Cl- homeodynamics underlying neonatal seizures.
  • Author(s): Fukuda, A.
  • Organizer: Pediatric Academic Societies (PAS) Annual Meeting
  • Place of Presentation: Washington DC, USA
  • Invited
• [Presentation] Maternal taurine as a modulator of GABAA receptor and Cl- homeostasis during perinatal period.
  • Author(s): Fukuda, A.
  • Organizer: The 15th International Symposium on Neonatal Seizures and Related Disorders (ISNS)
  • Place of Presentation: 東京
  • Invited
• [Presentation] Pre- and post-synaptic switches of GABA actions in the spinal nucleus of the trigeminal nerve in a rat model of trigeminal neuropathic pain.
  • Author(s): Kumada, T., Wei, B., Furukawa, T., Inoue, K., Watanabe, M., Sato, K., and Fukuda, A.
  • Organizer: The 12th Kyungpook-Hamamatsu Joint Medical Symposium Hamamatsu Meeting
  • Place of Presentation: Hamamatsu, Japan.
• [Book] Chloride homeodynamics underlying pathogenic modal shifts of GABA actions. Chapter 46. In : J.L.R. RUBENSTEIN and P. RAKIC editors : Comprehensive Developmental Neuroscience : Cellular Migration and Formation of Neuronal Connections (2013)
  • Author(s): Fukuda, A.
  • Publisher: Amsterdam : Academic Press
• [Book] Multimodal GABA_A receptor functions on cell development. Chapter 50. In : J.L.R. RUBENSTEIN and P. RAKIC editors : Comprehensive Developmental Neuroscience : Cellular Migration and Formation of Neuronal Connections (2013)
  • Author(s): Fukuda, A. Nakanishi, Y., Kumada, T. and Furukawa, T.
  • Publisher: Amsterdam : Academic Press
• [Book] Chloride homeodynamics underlying pathogenic modal shifts of GABA actions. Chapter 46. Cellular Migration and Formation of Neuronal Connections (2013)
  • Author(s): Fukuda, A.
  • Total Pages: 1080
  • Publisher: Academic Press
• [Book] Multimodal GABAA receptor functions on cell development. Chapter 50. Cellular Migration and Formation of Neuronal Connections (2013)
  • Author(s): Fukuda, A. Nakanishi, Y., Kumada, T. and Furukawa, T.
  • Total Pages: 1080
  • Publisher: Academic Press
• [Book] Does elevated intracellular chloride cause epilepsy in focal cortical dysplasia? (Chspter IV) In: Dysplasia: Causes, Types and Treatment Options. (2012)
  • Author(s): Shimizu-Okabe, C., Okabe, A., and Fukuda, A.
  • Publisher: L.M. Sexton and H. J. Leach. Nova Science Publishers, Hauppauge.
• [Remarks]
  • URL: http://www.hama-med.ac.jp/uni_education_igakubu_igaku_seiri1.html
• [Remarks] 浜松医科大学神経生理学講座
  • URL: http://www.hama-med.ac.jp/uni_education_igakubu_igaku_seiri1.html