Prenatal origin of the risk of mental disorders caused by the defects of maternal-fetal signal relay
| Project/Area Number |
24659512
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 大脳皮質 / 白血病抑制因子 / 妊娠 / 胎盤 / 炎症 / DOHaD / 母胎児間シグナル / 母体免疫 / インターロイキン６ / 副腎皮質刺激ホルモン / 神経幹細胞 |
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| Outline of Final Research Achievements |
Effects of maternal immune activation (MIA) induced by Polyinosinic:polycytidylic acid (Poly I:C) administration (4 mg or 20 mg/kg BW) into pregnant mice were investigated. The MIA-dams demonstrated that alteration of maternal serum IL-6 level was correlated with Poly I: C in a dose dependent manner. However, leukemia inhibitory factor (LIF) level of cerebrospinal fluid and adrenocorticotropic hormone (ACTH) in serum in embryos were decreased by injection of Poly I:C at 20 mg/kg BW into dams. In addition, the proliferating neural stem/progenitor cells and the post mitotic neurons in the dorsal cerebrum were decreased in number by injection of Poly I:C at 20 mg/kg BW into dams. The dorsal cerebrum of embryos with administration of LIF (5μg;g/kg BW) into dams exhibited that 14 of the top 20 up-regulated genes are the autism-related genes, suggesting that the interference of maternal-fetal LIF signaling relay by MIA results in the prenatal risk of autism.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Melanocortins Contribute to Sequential Differentiation and Enucleation of Human Erythroblasts via Melanocortin Receptors 1,2 and 52015
Author(s)
Simamura E, Arikawa T, Ikeda T, Shimada H, Shoji H, Masuta H, Nakajima Y, Otani H, Yonekura H, Hatta T
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Journal Title
PLOS ONE
Volume: 10
Issue: 4
Pages: 1-17
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Expression pattern of Galectin 4in rat placentation.2012
Author(s)
Arikawa T,Simamura E,Shimada H,NishiN,TatsunoT,IshigakiY,TomosugiN,YamashiroC,HataT,TakegamiT,MogamiH,YamaguchiK,NakamuraT,OtaniH,HattaT,ShojiH.
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Journal Title
Placenta
Volume: 33
Issue: 10
Pages: 885-887
DOI
Related Report
Peer Reviewed
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[Presentation] ラット新生児の定量的人工哺育システムの開発2014
Author(s)
内芝舞実, 島村英理子, 坂田ひろみ, 島田ひろき, 東 伸明, 有川智博, 東海林博樹, 福井義浩, 八田稔久
Organizer
第54回日本先天異常学会学術集会
Place of Presentation
麻布大学（神奈川県 相模原市）
Year and Date
2014-07-26 – 2014-07-27
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