| Project/Area Number |
24659514
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|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Dermatology
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|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
NISHIE Wataru 北海道大学, 北海道大学病院, 講師 (20443955)
|
|---|
| Project Period (FY) |
2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
|
|---|
| Keywords | 皮膚生理学 |
|---|
| Research Abstract |
Collagen XVII (COL17) is the major autoantigen for bullous pemphigoid. Juxtamembranous NC16A domain of COL17 contains major epitopes, in which potential coiled-coil exits. The aim of this study is to address the pathomechanism of the coiled-coils. The experiments disclosed that coiled-coils are essential motives for COL17 to form triple-helical structure; in addition the motived can be targeted by proteases when miss-folded COL17 are produced. Thus, the domain has a novel vital role for quality checking of folded COL17.
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