A new animal model of systemic sclerosis

• Project/Area Number: 24659522
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: The University of Tokyo
• Principal Investigator: SATO Shinichi 東京大学, 医学部附属病院, 教授 (20215792)
• Co-Investigator(Kenkyū-buntansha): ASANO Yoshihide 東京大学, 医学部附属病院, 講師 (60313029)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 全身性強皮症 / トポイソメラーゼI / 完全フロイドアジュバンド / IL-6 / 皮膚硬化 / 肺線維化 / 自己免疫 / 免疫学

Research Abstract

To assess the contribution of anti-DNA topoisomerase I(anti-topo I)antibody, tissue fibrosis and cytokine production were examined in mice treated with topo I and either Freund's complete adjuvant (CFA) or Freund's incomplete adjuvant(IFA).
Treatment with topo I and CFA,in contrast to treatment with topo I and IFA,induced skin and lung fibrosis with increased interleukin (IL)-6 and IL-17 production. Anti-topo I antibody levels were greater in mice treated with topo I and CFA than with topo I and IFA.Furthermore,treatment with topo I and CFA increased Th2 and Th17 cell frequencies in bronchoalveolar lavage fluid,whereas treatment with topo I and IFA increased Th1 and Treg cell frequencies.Moreover,loss of IL-6 expression ameliorated skin and lung fibrosis and decreased Th2 and Th17 cell frequencies. This study shows that treatment with topo I and CFA induces SSc-like tissue fibrosis and autoimmunity.

Research Products

• [Journal Article] Serum apelin levels : clinical association with vascular involvements in patients with systemic sclerosis (2013)
  • Author(s): Aozasa N, Asano Y, Akamata K, Noda S, Masui Y, Yamada D, Tamaki Z, Tada Y, Sugaya M, Kadono T, Sato S.
  • Journal Title: J Eur Acad Dermatol Venereol Volume: 27(1) Pages: 37-42
• [Journal Article] Serum levels of ADAM12-S : possible association with the initiation and progression of dermal fibrosis and interstitial lung disease in patients with systemic sclerosis (2013)
  • Author(s): Taniguchi T, Asano Y, Akamata K, Aozasa N, Noda S, Takahashi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Yanaba K, Tada Y, Sugaya M, Kadono T, Sato S.
  • Journal Title: J Eur Acad Dermatol Venereol Volume: 27(6) Pages: 747-753
• [Journal Article] The dynamics of serum angiopoietin-2 levels correlates with the efficacy of intravenous cyclophosphamide pulse for interstitial lung disease associated with systemic sclerosis (2013)
  • Author(s): Takahashi T, Asano Y, Akamata K, Aozasa N, Taniguchi T, Noda S, Masui Y, Ichimura Y, Toyama T, Tamaki Z, Tada Y, Sugaya M, Kadono T, Sato S.
  • Journal Title: Mod Rheumatol Volume: 23(5) Pages: 884-890
• [Journal Article] Clinical significance of serum retinol binding protain-4 levels in patients with systemic sclerosis (2013)
  • Author(s): Toyama T, Asano Y, Takahashi T, Aozasa N, Akamata K, Noda S, Taniguchi T, Ichimura Y, Sumida H, Tamaki Z, Masui Y, Tada Y, Sugaya M, Sato S, Kadono T.
  • Journal Title: J Eur Acad Dermatol Venereol Volume: 27(3) Pages: 337-344
• [Journal Article] A randomized, double-blind, placebo-controlled trial : intravenous immunoglobulin treatment in patients with diffuse cutaneous systemic sclerosis (2013)
  • Author(s): Takehara K, Ihn H, Sato S.
  • Journal Title: Clin Exp Rheumatol Volume: 31(2 Suppl 76) Pages: 151-156
• [Journal Article] A possible contribution of decreased cathepsin V expression caused by Fli deficiency to the development of dermal fibrosis and proliferative vasculopathy in systemic sclerosis (2013)
  • Author(s): Noda S, Asano Y, Takahashi T, Akamata K, Aozasa N, Taniguchi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Yanaba K, Tada Y, Sugaya M, Kadono T, Sato S.
  • Journal Title: Rheumatology Volume: 52(5) Pages: 790-799
• [Journal Article] Serum chemokine levels as prognostic markers in patients with early systemic sclerosis : a multicenter,prospective,observational study (2013)
  • Author(s): Hasegawa M, Asano Y, Endo H, Fujimoto M, Goto D, Ihn H, Inoue K, Ishikawa O, Kawaguchi Y, Kuwana M, Ogawa F, Takahashi H, Tanaka S, Sato S, Takehara K.
  • Journal Title: Mod Rheum Volume: 23(6) Pages: 1076-1084
• [Journal Article] Serum angiopoietin-like protein 3 levels : a possible correlation with progressive skin sclerosis, digital ulcers, and pulmonary vascular involvement in patients with systemic sclerosis (2013)
  • Author(s): Ichimura Y, Asano Y, Akamata K, Aozasa N, Noda S, Taniguchi T, Takahashi T, Toyama T, Sumida H, Kuwano Y, Yanaba K, Tada Y, Sugaya M, Sato S, Kadono T.
  • Journal Title: Acta Derm-Venereol Volume: (Epub ahead of point)
• [Journal Article] Fli1 deficiency contributes to the suppression of endothelial CXCL5 expression in systemic sclerosis (2013)
  • Author(s): Ichimura Y, Asano Y, Akamata K, Takahashi T, Noda S, Taniguchi T, Toyama T, Aozasa N, Sumida H, Kuwano Y, Yanaba K, Tada Y, Sugaya M, Sato S, Kadono T.
  • Journal Title: Arch Dermatol Res Volume: (Epub ahead of point)
• [Journal Article] A possible contribution of visfatin to the resolution of skin sclerosis in patients with diffuse cutaneous systemic sclerosis via a direct anti-fibrotic effect on dermal fibroblasts and Th1 polarization of the immune response (2013)
  • Author(s): Masui Y, Asano Y, Shibata S, Noda S, Akamata K, Aozasa N, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Yanaba K, Tada Y, Sugaya M, Sato S, Kadono T.
  • Journal Title: Rheumatology (Oxford) Volume: 52 Pages: 1239-1244
• [Journal Article] Serum resistin levels : a possible correlation with pulmonary vascular involvement in patients with systemic sclerosis (2013)
  • Author(s): Masui Y, Asano Y, Akamata K, Aozasa N, Noda S, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Yanaba K, Tada Y, Sugaya M, Sato S, Kadono T.
  • Journal Title: Rheumatol Int Volume: (Epub ahead of point)
• [Journal Article] Presence of desaturated hemoglobin enhances the contribution of blood cells to flow-mediated dilation in subjects with systemic sclerosis (2013)
  • Author(s): Amiya E, Takata M, Watanabe M, Takahashi T, Asano Y, Hatano M, Ozeki A, Watanabe A, Kawarasaki S, Tamaki Z, Taniguchi T, Ichimura Y, Toyama T, Nagai R, Sato S, Komuro I.
  • Journal Title: Int J Cardiol Volume: 168(3) Pages: 3125-3127
• [Journal Article] Association of nerve growth factor, CCL1, CCL26, and IgE with pruritus in cutaneous T-cell lymphoma. (2013)
  • Author(s): Suga H, Sugaya M, Miyagaki T, Ohmatsu H, Fujita H, Kagami S, Asano Y, Tada Y, Kadono T, Sato S.
  • Journal Title: Acta Derm Venereol. Volume: 93 Pages: 144-149
  • DOI: 10.2340/00015555-1428
  • Peer Reviewed
• [Journal Article] Clinical significance of monitoring serum adiponectin levels during intravenous pulse cyclophosphamide therapy in interstitial lung disease associated with systemic sclerosis (2013)
  • Author(s): Masui Y, Asano Y, Takahashi T, Shibata S, Akamata K, Aozasa N, Noda S, Taniguchi T, Ichimura Y, Toyama T, Tamaki Z, Sumida H, Yanaba K, Tada Y, Sugaya M, Sato S, Kadono T:
  • Journal Title: Mod Rheumatol. Volume: 23-2 Pages: 323-329
  • DOI: 10.1007/s10165-012-0660-7
  • NAID: 10031167705
  • Peer Reviewed
• [Journal Article] Analysis of serum chemokine levels in patients with HIV-associated eosinophilic folliculitis. (2013)
  • Author(s): Yokobayashi H, Sugaya M, Miyagaki T, Kai H, Suga H, Yamada D, Minatani Y, Watanabe K, Kikuchi Y, Tamaki T, Sato S.
  • Journal Title: J Eur Acad Dermatol Venereol Volume: 27 Pages: 212-216
  • DOI: 10.1111/j.1468-3083.2012.04592.x
  • Peer Reviewed
• [Journal Article] Frequent Relapse and Irradiation Strategy in Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type. (2013)
  • Author(s): Sumida H, Sugaya M, Miyagaki T, Minatani Y, Ohno Y, Uwajima Y, Ohmatsu H, Fujita H, Yamashita H, Sato S:
  • Journal Title: Acta Derm Venereol. Volume: 93-1 Pages: 97-98
  • DOI: 10.2340/00015555-1424
  • Peer Reviewed
• [Journal Article] IL-27 activates Th1-mediated responses in imiquimod-induced psoriasis-like skin lesions (2013)
  • Author(s): Shibata S, Tada Y, Asano Y, Yanaba K, Sugaya M, Kadono T, Kanda N, Watanabe S, Sato S
  • Journal Title: J Invest Dermatol. Volume: 133-2 Pages: 479-488
  • DOI: 10.1038/jid.2012.313
  • Peer Reviewed
• [Journal Article] Decreased cathepsin V expression due to Fli1 deficiency contributes to the development of dermal fibrosis and proliferative vasculopathy in systemic sclerosis. (2013)
  • Author(s): Noda S, Asano Y, Takahashi T, Akamata K, Aozasa N, Taniguchi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Yanaba K, Tada Y, Sugaya M, Kadono T, Sato S
  • Journal Title: Rheumatology (Oxford). Volume: 52 Pages: 790-799
  • DOI: 10.1093/rheumatology/kes379
  • Peer Reviewed
• [Journal Article] Increased production of soluble inducible costimulator in patients with diffuse cutaneous systemic sclerosis. (2013)
  • Author(s): Yanaba K, Asano Y, Noda S, Akamata K, Aozasa N, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Tada Y, Sugaya M, Kadono T, Sato S
  • Journal Title: Arch Dermatol Res Volume: 305-1 Pages: 17-23
  • DOI: 10.1007/s00403-012-1292-7
  • Peer Reviewed
• [Journal Article] Increased circulating fibrinogen-like protein 2 in patients with systemic sclerosis (2013)
  • Author(s): Yanaba K, Asano Y, Noda S, Akamata K, Aozasa N, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Tada Y, Sugaya M, Kadono T, Sato S:
  • Journal Title: Clin Rheumatol Volume: 32-1 Pages: 43-47
  • DOI: 10.1007/s10067-012-2089-y
  • Peer Reviewed
• [Journal Article] Decrease in circulating autotaxin by oral administration of prednisolone. (2013)
  • Author(s): Sumida H
  • Journal Title: Clinica Chimica Acta Volume: 415 Pages: 74-80
  • DOI: 10.1016/j.cca.2012.10.003
  • Peer Reviewed
• [Journal Article] Clinical significance of serum soluble Tie1 levels in patients with systemic sclerosis (2013)
  • Author(s): Noda S, Asano Y, Aozasa N, Akamata K, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Yanaba K, Tada Y, Sugaya M, Kadono T, Sato S:
  • Journal Title: Arch Dermatol Res Volume: 305-4 Pages: 325-31
  • DOI: 10.1007/s00403-012-1307-4
  • Peer Reviewed
• [Journal Article] Serum levels of galectin-3 : possible association with fibrosis, aberrant angiogenesis, and immune activation in patients with systemic sclerosis (2012)
  • Author(s): Taniguchi T, Asano Y, Akamata K, Noda S, Masui Y, Yamada D, Takahashi T, Ichimura Y, Toyama T, Tamaki Z, Tada Y, Sugaya M, Kadono T, Sato S.
  • Journal Title: J Rheumato Volume: l39(3) Pages: 539-544
• [Journal Article] Effects of bosentan on non-digital ulcers in patients with systemic sclerosis (2012)
  • Author(s): Taniguchi T, Asano Y, Hatano M, Tamaki Z, Tomita M, Kawashima T, Miyazaki M, Sumida H, Akamata K, Takahashi T, Ichimura Y, Toyama T, Sugita M, Noda S, Yao A, Kinugawa K, Sato S.
  • Journal Title: Br J Dermatol Volume: 166(2) Pages: 417-421
• [Journal Article] Serum levels of soluble CD21 in patients with systemic sclerosis (2012)
  • Author(s): Tomita M, Kaodono T, Yazawa N, Kawashima T, Tamaki Z, Ashida R, Ohmatsu H, Asano Y, Sugaya M, Kubo M, Ihn H, Tamaki K, Sato S.
  • Journal Title: Rheumatol Int Volume: 32(2) Pages: 317-321
• [Journal Article] Serum adiponectin levels inversely correlate with the activity of progressive skin sclerosis in patients with diffuse cutaneous systemic sclerosis (2012)
  • Author(s): Masui Y, Asano Y, Shibata S, Noda S, Aozasa N, Akamata K, Yamada D, Tamaki Z, Tada Y, Sugaya M, Sato S, Kadono T.
  • Journal Title: J Eur Acad Dermatol Venereol Volume: 26(3) Pages: 354-360
• [Journal Article] Clinical significance of serum growth differentiation factor-15 levels in systemic sclerosis : association with disease severity (2012)
  • Author(s): Yanaba K, Asano Y, Tada Y, Sugaya M, Kadono T, Sato S.
  • Journal Title: Mod Rheumatol Volume: 22(5) Pages: 668-675
  • NAID: 10031027596
• [Journal Article] Clinical significance of circulating platelet-activating factor acetylhydrolase levels in systemic sclerosis (2012)
  • Author(s): Yanaba K, Asano Y, Tada Y, Sugaya M, Kadono T, Sato S.
  • Journal Title: Arch Dermatol Res Volume: 304(3) Pages: 203-208
• [Journal Article] Investigation of prognostic factors for skin sclerosis and lungfunction in Japanese patients with early systemic prospect observational study.sclerosis : a multicentre (2012)
  • Author(s): Hasegawa M, Asano Y, Endo H, Fujimoto M, Goto D, Ihn H, Inoue K, Ishikawa O, Kawaguchi Y, Kuwana M, Muro Y, Ogawa F, Sasaki T, Takahashi H, Tanaka S, Takehara K, Sato S.
  • Journal Title: Rheumatology (Oxford) Volume: 51(1)
• [Journal Article] Association of UBE2L3 polymorphisms with diffuse cutaneous systemic sclerosis in a Japanese population (2012)
  • Author(s): Hasebe N, Kawasaki A, Ito I, Kawamoto M, Hasegawa M, Fujimoto M, Furukawa H, Tohma S, Sumida T, Takehara K, Sato S, Kawaguchi Y, Tsuchiya N.
  • Journal Title: Ann Rheum Dis Volume: 71(7) Pages: 1259-1260
• [Journal Article] A possible contribution of altered cathepsin B expression to the development of skin sclerosis and vasculopathy in systemic sclerosis (2012)
  • Author(s): Noda S, Asano Y, Akamata K, Aozasa N, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Yanaba K, Tada Y, Sugaya M, Kadono T, Sato S.
  • Journal Title: PLos One Volume: 7(2)
• [Journal Article] Clinical significance of serum levels of secretory leukocyte protease inhibitor in patients with systemic sclerosis (2012)
  • Author(s): Aozasa N, Asano Y, Akamata K, Noda S, Masui Y, Tamaki Z, Tada Y, Sugaya M, Kadono T, Sato S.
  • Journal Title: Mod Rheumatol Volume: 22(4) Pages: 576-583
  • NAID: 10031027168
• [Journal Article] Increased serum soluble CD147 levels in patients with systemic sclerosis : association with scleroderma renal crisis (2012)
  • Author(s): Yanaba K, Asano Y, Tada Y, Sugaya M, Kadono T, Hamaguchi Y, Sato S.
  • Journal Title: Clin Rheumatol Volume: 31(5) Pages: 835-839
• [Journal Article] A possible contribution of elevated serum clusterin levels to the development of digital ulcers and pulmonary arterial hypertension in systemic sclerosis (2012)
  • Author(s): Yanaba K, Asano Y, Tada Y, Sugaya M, Kadono T, Sato S.
  • Journal Title: Arch Dermatol Res Volume: 304(6) Pages: 459-463
• [Journal Article] Clinical significance of serum decoy receptor 3 levels in patints with systemic sclerosis (2012)
  • Author(s): Yamada D, Asano Y, Takahashi T, Masui Y, Aozasa N, Akamata K, Noda S, Tamaki Z, Tada Y, Sugaya M, Sato S, Kadono T.
  • Journal Title: Eur J Dermatol Volume: 22(3) Pages: 351-357
• [Journal Article] Augmented production of soluble CD93 in patients with systemic sclerosis and clinical association with severity of skin sclerosis (2012)
  • Author(s): Yanaba K, Asano Y, Noda S, Akamata K, Aozasa N, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Tada Y, Sugaya M, Kadono T, Sato S.
  • Journal Title: Br J Dermatol Volume: 167(3) Pages: 542-547
• [Journal Article] Constitutive activation of c-Abl/protein kinase C-δ/Fli pathway in dermal fibroblasts derived from patients with localized scleroderma (2012)
  • Author(s): Noda S, Asano Y, Akamata K, Aozasa N, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Yanaba Y, Tada Y, Sugaya M, Kadono T, Sato S.
  • Journal Title: Br J Dermatol Volume: 167(5) Pages: 1098-1105
• [Journal Article] Clinical significance of monitoring serum adiponectin levels during intravenous pulse cyclophosphamide therapy in interstitial lung disease associated with systemic sclerosis (2012)
  • Author(s): Masui Y, Asano Y, Takahashi T, Shibata S, Akamata K, Aozasa N, Noda S, Taniguchi T, Ichimura Y, Toyama T, Tamaki Z, Sumida H, Yanaba K, Tada Y, Sugaya M, Sato S, Kadono T.
  • Journal Title: 2012 Mod Rheumatol Volume: 23(2) Pages: 323-329
  • NAID: 10031167705
• [Journal Article] Association of UBE2L3 polymorphisms with diffuse cutaneous systemic sclerosis in a Japanesepopulation. (2012)
  • Author(s): Hasebe N, Kawasaki A, Ito I, Kawamoto M, Hasegawa M, Fujimoto M, Furukawa H, Tohma S, Sumida T, Takehara K, Sato S, Kawaguchi Y, Tsuchiya N
  • Journal Title: Ann Rheum Dis. Volume: 71 Pages: 1259-1260
  • DOI: 10.1136/annrheumdis-2011-201091
  • Peer Reviewed
• [Journal Article] In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokineand integrin signaling (2012)
  • Author(s): S.Nishimura
  • Journal Title: Blood. Volume: 119 Pages: 128-131
  • DOI: 10.1182/blood-2011-09-381400
  • Peer Reviewed
• [Journal Article] erum angiogenin levels are decreased in patients with psoriasis. (2012)
  • Author(s): Miyagaki T, Sugaya M, Kamata M, Suga H, Morimura S, Tatsuta A, Uwajima Y, Yamamoto M, Shibata S, Fujita H, Asano Y, Kadono T, Sato S, Tada Y.
  • Journal Title: Clin Exp Dermatol Volume: 37 Pages: 792-3
  • DOI: 10.1111/j.1365-2230.2012.04345.x
  • Peer Reviewed
• [Journal Article] 強皮症の治療の進歩について． (2012)
  • Author(s): 佐藤伸一
  • Journal Title: 皮膚病診療 Volume: 34-6 Pages: 594-594
• [Journal Article] 全身性強皮症の診断と高齢者における診療上の注意点 (2012)
  • Author(s): 161. 簗場広一，佐藤伸一
  • Journal Title: Geriatric Medicine老年医学 Volume: 50-6 Pages: 703-706
• [Presentation] レクチャー (2013)
  • Author(s): 佐藤伸一
  • Organizer: 第4回日本研究皮膚科学会きさらぎ塾
  • Place of Presentation: ホテル日航アリビラ（沖縄）
• [Presentation] 【教育講演7. 膠原病の自己抗体の読み方・考え方】 【舌・軟口蓋の偏倚・萎縮を来した剣創状強皮症の一例】 (2013)
  • Author(s): 佐藤伸一
  • Organizer: 第76回日本皮膚科学東京支部学術大会
  • Place of Presentation: 京王プラザホテル
• [Presentation] Special Lecture. Scleroderma:preseut and Future (2012)
  • Author(s): 佐藤伸一
  • Organizer: 64ｔｈ KDA Spring meating,Deagu,Korea
  • Place of Presentation: Korea
• [Book] 日本皮膚科学会認定皮膚科専門医 研修講習会テキスト (2013)
  • Author(s): 佐藤伸一
  • Total Pages: 1
  • Publisher: 日本皮膚科学会刊
• [Book] 皮膚疾患最新の治療2013-2014 (2013)
  • Author(s): 佐藤伸一
  • Total Pages: 1
  • Publisher: 南江堂
• [Book] 臨床検査ガイド2013～2014 (2013)
  • Author(s): 菅谷誠，佐藤伸一
  • Publisher: ㈱文光堂
• [Book] 免疫・アレルギー疾患の分子標的と治療薬辞典 (2013)
  • Author(s): 門野岳史，佐藤伸一
  • Total Pages: 14
  • Publisher: ㈱羊土社
• [Book] 生物学的製剤のup to date Ｕｓｔｅｋｉｎｕｍａｂの関節症性乾癬に対する効果 (2012)
  • Author(s): 藤田英樹,佐藤伸一
  • Publisher: 科学評論社 /リウマチ科
• [Book] ステロイドの外用剤と内服の違い正しいステロイドの使い方2.外用剤編 (2012)
  • Author(s): 小寺雅也,佐藤伸一
  • Publisher: 医薬ジャーナル社
• [Book] 皮膚科サブスペシャリティーシリーズ1冊でわかる皮膚アレルギー (2012)
  • Author(s): 浅野善英,佐藤伸一
  • Publisher: 文光堂
• [Book] WHAT’ＮＥＷin皮膚科学2012-2013 (2012)
  • Author(s): 浅野善英,佐藤伸一
  • Publisher: メディカルレビュー社，
• [Book] 今日の皮膚疾患治療指針 (2012)
  • Author(s): 佐藤伸一
  • Publisher: 医学書院
• [Book] ファーマナビゲーター抗ヒスタミン薬編 (2012)
  • Author(s): 佐藤伸一
  • Publisher: メディカルレビュー社，
• [Book] 臨床皮膚科 (2012)
  • Author(s): 佐藤伸一
  • Publisher: 医学書院
• [Book] 診療ガイドラインUP-TO-DATE (2012)
  • Author(s): 浅野善英,佐藤伸一
  • Publisher: メディカルレビュー社，
• [Book] American College of Rheumatology (2012)
  • Author(s): Terao C,Ohmura K,Kawaguchi Y,Nishimoto T,Kawasaki A,Takehawa K,Furukawa H,Kochi Y,Ota Y,Ikari K,Sato S,Tohma S,Yamada R,Yamamoto K,Kubo M,Yamanaka H,Kuwana M,Tsuchiya N,Matsuda F,Mimori T:
  • Publisher: Arthritis&Rheumatism
• [Book] 医学のあゆみ (2012)
  • Author(s): 佐藤伸一
  • Total Pages: 1
  • Publisher: 医歯薬出版株式会社