| Project/Area Number |
24659523
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
|
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| Research Institution | University of Tsukuba (2013)
Kanazawa University (2012) |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
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| Keywords | 線維化 / 皮膚免疫 / 強皮症 / 細胞 / 免疫 / 皮膚疾患 |
|---|
| Research Abstract |
Recent studies have clarified the protective role of regulatory B cells (Bregs) in various inflammatory and autoimmune diseases. In this study, we studied the role of Bregs in fibortic diseases using sclerodermatous chronic graft-versus-host disease (Scl-cGVHD) model, which is characterized by fibrosis and autoimmune features resembling those of systemic sclerosis (SSc). CD19-deficient (CD19-/-) mice were used as donors or recipients in this model. CD19-/- donors induced more severe Scl-cGVHD than wild-type donors, while CD19-/- recipients showed no significant differences compared with wild-type recipients. IL-10-producing regulatory B cells (B10 cells) were not reconstituted by CD19-/- donor cells, and early adoptive transfer of B10 cells attenuated the augmented manifestations of CD19-/- donor-induced Scl-cGVHD. Therefore, donor-derived B10 cells have a suppressive role in Scl-cGVHD development.
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