Role of mast cells and basophils in the development of atopic dermatitis
| Project/Area Number |
24659528
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Kyoto University |
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Principal Investigator |
MIYACHI Yoshiki 京都大学, 医学(系)研究科(研究院), 教授 (30127146)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | アレルギー / 皮膚科学 / 好塩基球 / アトピー性皮膚炎 / Atopic dermatitis / mast cell / basophils |
|---|
| Research Abstract |
The relative contributions of basophils and dendritic cells in Th2 skewing to foreign antigen exposure remain unclear. Here we report the ability of basophils to induce Th2 polarization upon epicutaneous sensitization with different antigens using basophil conditionally depleted Bas TRECK transgenic mice. Basophils are responsible for Th2 skewing to haptens and peptide antigens, but not protein antigens in vivo. Consistent with this, basophils cannot take up or process ovalbumin protein in significant quantities, but present ovalbumin peptide to T cells for Th2 differentiation via major histocompatibility complex class II. Intriguingly, basophils promote Th2 skewing upon ovalbumin protein exposure in the presence of dendritic cells. Taken together, our results suggest that basophils alone are able to induce Th2 skewing with haptens and peptide antigens but require dendritic cells for the induction of Th2 for protein antigens upon epicutaneous immunization.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Basophils are required for the induction of Th2 immunity to haptens and peptide antigens.2013
Author(s)
Otsuka A, Nakajima S, Kubo M, Egawa G, Honda T, Kitoh A, Nomura T, Hanakawa S, Sagita Moniaga C, Kim B, Matsuoka S, Watanabe T, Miyachi Y , Kabashima K.
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Journal Title
Nature Communications
Volume: 4
Issue: 1
Pages: 1739-1739
DOI
Related Report
Peer Reviewed
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[Journal Article] Extranodal NK/T-cell lymphoma, nasal type, presenting pseudoepitheliomatous hyperplasia as a mimic of squamous cell carcinoma2012
Author(s)
Nonomura Y, Otsuka A, Endo Y, Fujisawa A, Miyagawa-Hayashin A, Sumiyoshi S, Kabashima K, Miyachi Y, Tanioka M
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Journal Title
Eur J Dermatol
Volume: 22(5)
Pages: 688-689
Related Report
Peer Reviewed
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[Journal Article] Sparganosis mansoni on abdominal skin, mimicking folliculitis and diagnosed by analysis of the mitochondrial cytochrome c oxidase subunit 1 gene, using polymerase chain reaction2012
Author(s)
Nonomura Y., Otsuka A., Endo Y., Fujisawa A., Nakajima N., Minamiguchi S., Miyagawa-Hayashino A., Yamada M., Tegoshi T., Yamasaki H., Kabashima K., Miyachi Y., Tanioka M.
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Journal Title
European Journal of Dermatology
Volume: 22
Issue: 6
Pages: 806-807
DOI
Related Report
Peer Reviewed
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