Establishment of biological research linked with community mental health service

• Project/Area Number: 24659535
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Tohoku University
• Principal Investigator: TOMITA Hiroaki 東北大学, 災害科学国際研究所, 教授 (90295064)
• Project Period (FY): 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: 脳神経疾患 / ストレス / 神経科学 / 社会科学 / マイクロアレイ

Research Abstract

Considerations in conducting mental health promotion and health survey were summarized. Saliva samples from victims of the Great East Japan Earthquake of2011 were collected upon informed-consent, and difference in comprehensive gene expression profiles of the samples between groups showing high- and lowpost-traumatic stress responses were analyzed. Data indicated the validity of analyzing saliva samples as an indicator of post-traumatic stress, as long as considerations on proportion of each component cell type in saliva.

Research Products

• [Journal Article] Missense mutations in the DNA-binding/dimerization domain of NFIX cause Sotos-like features (2012)
  • Author(s): Yoneda Y, Saitsu H, Touyama M, Makita Y, Miyamoto A, Hamada K, Kurotaki N, Tomita H, Nishiyama K, Tsurusaki Y, Doi H, Miyake N, Ogata K, Naritomi K, Matsumoto N
  • Journal Title: J Hum Genet Volume: 57巻 Issue: 3 Pages: 207-211
  • DOI: 10.1038/jhg.2012.7
  • NAID: 10030712151
  • Peer Reviewed
• [Journal Article] Mutations in PRRT2 responsible for paroxysmal kinesigenic dyskinesias also cause benign familialinfantile convulsions. (2012)
  • Author(s): Ono S, Yoshiura K , KinoshitaA, Kikuchi T, Nakane Y, Kato N,Sadamatsu M , Konishi T , Nagamitsu S , Matsuura M, Yasuda A, KomineM, Kanai K , Inoue T , Osamura T , Saito K , Hirose S, Koide H, Tomita H , Ozawa H , Niikawa N and Kurotaki N.
  • Journal Title: J Hum Genet Volume: 57 Issue: 5 Pages: 1-4
  • DOI: 10.1038/jhg.2012.23
  • Peer Reviewed
• [Journal Article] Expression analysis of a novel mRNA variant of the schizophrenia risk gene ZNF804A. (2012)
  • Author(s): Okada T, et al,
  • Journal Title: Schizophr Res, Volume: 141(2-3): Issue: 2-3 Pages: 277-278
  • DOI: 10.1016/j.schres.2012.08.015
  • Peer Reviewed
• [Journal Article] 災害によるPTSDの疫学とリスクファクター.特集災害ストレスとPTSD;災害医療の観点から (2012)
  • Author(s): 富田博秋、鈴木大輔
  • Journal Title: Pharma Medica Volume: 30(12) Pages: 13-17
  • Peer Reviewed
• [Journal Article] うつ病の死後脳研究によるバイオマーカー探索 (2012)
  • Author(s): 富田博秋
  • Journal Title: 医学のあゆみ Volume: 244 Pages: 496-501
  • Peer Reviewed
• [Journal Article] 災害によるPTSDの疫学とリスクファクター． (2012)
  • Author(s): 富田博秋
  • Journal Title: Pharma Medica Volume: 30 Pages: 13-17
• [Presentation] The influence of individual physical- social characteristics on mental health among the Great East Japan Earthquake victims.(沿岸部被災者の 精神的健康に対する生活状況および個人 的特性の影響) (2012)
  • Author(s): 上田譲,鈴木大輔,築田美抄,金吉晴,辻一郎,富田博秋
  • Organizer: International Society Traumatic Stress Studies 28th Annual Meeting(第28回 国際トラウマティッ ク・ストレス学会)
  • Place of Presentation: アメリカ/ロサンゼ ルス
  • Year and Date: 2012-11-02
• [Presentation] Habits of Alcohol Use and Cigarette Smoking in Disaster Victims Relate to Mental Health (2012)
  • Author(s): Suzuki D, Tsukida M, Ueda Y, Kim Y, Tsuji I,Tomita H
  • Organizer: International Society Traumatic Stress Studies 28th Annual Meeting(第28回 国際トラウマティッ ク・ストレス学会)
  • Place of Presentation: アメリカ/ロサンゼ ルス
  • Year and Date: 2012-11-02
• [Presentation] Social network and mental health conditions among the Great East JapanEarthquake victims.(人のつながりと 被災者の精神的健康) (2012)
  • Author(s): 築田美抄,上田譲,鈴木大輔,金吉晴,辻一郎,富田博秋
  • Organizer: International Society Traumatic Stress Studies28th Annual Meeting(第28回 国際トラ ウマティック・ストレス学会)
  • Place of Presentation: アメリ カ/ロサンゼルス
  • Year and Date: 2012-11-02
• [Presentation] Gene expression profiling of specificspecific immune cells in peripheral blood samples as a tool for neuropsychoimmunological bases of traumatic stress-related diseases(トラウマ性ストレス関連疾患の精神神経免疫相関機序解明への応用 を見据えた末梢血中の免疫細胞の遺伝子 発現プロファイリング解析) (2012)
  • Author(s): 小野千晶,兪志前,石井直人,富田博秋
  • Organizer: International Society Traumatic Stress Studies 28th Annual Meeting(第28回国際トラウマティック・スト レス学会)
  • Place of Presentation: アメリカ/ロサンゼルス
  • Year and Date: 2012-11-01
• [Presentation] Multi-faceted approaches to identify social, psychological (2012)
  • Author(s): Tomita H, Ono C, Yu Z, Suzuki D, Tsukida M, Ueda Y, Hozawa A, Tsuji I
  • Organizer: and biological factors involved in disaster-related mental health problems 8th APRU Research Symposium on Multi-hazards around the Pacific Rim
  • Place of Presentation: 仙台
  • Year and Date: 2012-09-21
• [Presentation] 災害精神医学と被災地精神保健の現況と展望 (2012)
  • Author(s): 富田博秋
  • Organizer: 第11回日本トラウマティック・ストレス学会
  • Place of Presentation: 福岡県春日市
  • Year and Date: 2012-06-10
• [Presentation] 末梢血中の特定の免疫細胞の遺伝子発現プロファイリング解析～トラウマ性ストレス関連疾患の精神神経免疫相関機序解明への応用を見据えて～ (2012)
  • Author(s): 小野千晶,兪志前,石井直人,富田博秋
  • Organizer: 第11回日本トラウマティック・ストレス学会
  • Place of Presentation: 福岡県春日市
  • Year and Date: 2012-06-10
• [Presentation] 被災者の飲酒・喫煙習慣と精神的健康との関連 (2012)
  • Author(s): 鈴木大輔,築田美抄,上田譲,金吉晴,辻一郎,富田博秋
  • Organizer: 第11回日本トラウマティック・ストレス学会
  • Place of Presentation: 福岡県春日市
  • Year and Date: 2012-06-10
• [Presentation] 沿岸部被災者の精神的健康に対する生活状況および個人的特性の影響 (2012)
  • Author(s): 上田譲,鈴木大輔,築田美抄,金吉晴,辻一郎,富田博秋
  • Organizer: 第11回日本トラウマティック・ストレス学会
  • Place of Presentation: 福岡県春日市
  • Year and Date: 2012-06-10
• [Presentation] 「人のつながり」と被災者の精神的健康 (2012)
  • Author(s): 築田美抄,上田譲,鈴木大輔,金吉晴,辻一郎,富田博秋
  • Organizer: 第11回日本トラウマティック・ストレス学会
  • Place of Presentation: 福岡県春日市
  • Year and Date: 2012-06-10
• [Presentation] Psychological Impact Learned from the 2011 Tohoku Earthquake (2012)
  • Author(s): Tomita H.
  • Organizer: UK-Japan Joint Workshop Disaster Risk Reduction
  • Place of Presentation: 東京(招待講演)
• [Presentation] Molecular conformational changes in microglia and differentiated monocitic cells induced by therapeutic concentrations of lithium (2012)
  • Author(s): Yu Z, Ono C, Tomita H.
  • Organizer: Collegium internationale neuro- psychopharmacologicum 28th congress
  • Place of Presentation: ス ウェーデン/ストックホルム
• [Presentation] Psychological Impact Learned from the 2011 Tohoku Earthquake. (2012)
  • Author(s): Tomita H
  • Organizer: UK-Japan Joint Workshop Disaster Risk Reduction
  • Place of Presentation: Tokyo, Japan
  • Invited
• [Presentation] Molecular conformational changes in microglia and differentiated monocitic cells induced by therapeutic concentrations of lithium. (2012)
  • Author(s): Yu Z, Ono C, Tomita H
  • Organizer: Collegium internationale neuro-psychopharmacologicum 28th congress.
  • Place of Presentation: Stockholm, Sweden
• [Presentation] Multi-faceted approaches to identify social, psychological, and biological factors involved in disaster-related mental health problems. (2012)
  • Author(s): Tomita H, Ono C, Yu Z, Suzuki D, Tsukida M, Ueda Y, Hozawa A, Tsuji I
  • Organizer: 8th APRU Research Symposium on Multi-hazards around the Pacific Rim
  • Place of Presentation: Sendai, Japan
• [Presentation] Gene expression profiling of specific immune cells in peripheral blood samples as a tool for neuropsychoimmunological bases of traumatic stress-related diseases. (2012)
  • Author(s): Ono C, Yu Z, Ishii N, Tomita H
  • Organizer: International Society for Traumatic Stress Studies 28th Annual Meeting
  • Place of Presentation: Los Angeles, United States
• [Presentation] The influence of individual physical-social characteristics on mental health among the Great East Japan Earthquake victims. (2012)
  • Author(s): Ueda Y, Suzuki D, Tsukida M, Kim Y, Tsuji I, Tomita H
  • Organizer: International Society for Traumatic Stress Studies 28th Annual Meeting
  • Place of Presentation: Los Angeles, United States
• [Presentation] Habits of Alcohol Use and Cigarette Smoking in Disaster Victims Relate to Mental Health. (2012)
  • Author(s): Suzuki D, Tsukida M, Ueda Y, Kim Y, Tsuji I, Tomita H
  • Organizer: International Society for Traumatic Stress Studies 28th Annual Meeting
  • Place of Presentation: Los Angeles, United States
• [Presentation] Social network and mental health conditions among the Great East Japan Earthquake victims. (2012)
  • Author(s): Tsukida M, Ueda Y, Suzuki D, Kim Y, Tsuji I, Tomita H
  • Organizer: International Society for Traumatic Stress Studies 28th Annual Meeting
  • Place of Presentation: Los Angeles, United States
• [Presentation] 災害精神医学と被災地精神保健の現況と展望． (2012)
  • Author(s): 富田博秋
  • Organizer: 第11回日本トラウマティック・ストレス学会
  • Place of Presentation: 福岡
  • Invited
• [Presentation] 末梢血中の特定の免疫細胞の遺伝子発現プロファイリング解析～トラウマ性ストレス関連疾患の精神神経免疫相関機序解明への応用を見据えて～． (2012)
  • Author(s): 小野千晶、兪志前、石井直人、富田博秋
  • Organizer: 第11回日本トラウマティック・ストレス学会
  • Place of Presentation: 福岡
• [Presentation] 被災者の飲酒・喫煙習慣と精神的健康との関連． (2012)
  • Author(s): 鈴木 大輔、築田 美抄、上田 穫、金吉晴、辻 一郎、富田 博秋
  • Organizer: 第11回日本トラウマティック・ストレス学会
  • Place of Presentation: 福岡
• [Presentation] 沿岸部被災者の精神的健康に対する生活状況および個人的特性の影響． (2012)
  • Author(s): 上田 穫、鈴木 大輔、築田 美抄、金吉晴、辻 一郎、富田 博秋
  • Organizer: 第11回日本トラウマティック・ストレス学会
  • Place of Presentation: 福岡
• [Presentation] 「人のつながり」と被災者の精神的健康． (2012)
  • Author(s): 築田 美抄、上田 穫、鈴木 大輔、金吉晴、辻 一郎、富田 博秋
  • Organizer: 第11回日本トラウマティック・ストレス学会
  • Place of Presentation: 福岡
• [Book] 東日本大震災を分析する (2013)
  • Author(s): 富田博秋
  • Publisher: 石書店
• [Book] 東日本大震災を分析する． (2013)
  • Author(s): 富田博秋
  • Publisher: 明石書店