| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Research Abstract |
Schizophrenia, one of the most detrimental common psychiatric disorders, occurs in all human ethnic groups but not in any animal species, indicating that it emerged during human evolution. To clarify the relation between schizohrenia and the architecture of human genome, the present study compared allele frequencies of polymorphisms associated with schizophrenia among major ethnic groups, Neandertals and Denisovans. Increased frequencies of the risk alleles of the polymorphisms associated with schizohrenia were found significantly in the Europeans and Asians, compared with Sub-Saharan African, Neandertals and Denisovans. These findings suggest that risk alleles have functioned preferentially during human evolution, particularly after "out of Africa", indicating positive selection of schizophrenia associated genes during modern human evolution.
|
