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New method of cognitive behavior therapy for adolescent depression considering the gender difference in mind and brain, and social development

Research Project

Project/Area Number 24659538
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionChiba University

Principal Investigator

SHIMIZU Eiji  千葉大学, 医学(系)研究科(研究院), 教授 (00292699)

Co-Investigator(Renkei-kenkyūsha) MATSUZAWA Daisuke  千葉大学, 大学院医学研究院, 講師 (10447302)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords認知行動療法 / 思春期うつ病 / 性差
Research Abstract

After developed disorder-specific cognitive behavior therapy (CBT), we have gotten an idea the pathologically specific CBT program for depression would be more effective. In the program, we considered that the patient's age and gender would be important factors. In this study, we used animal model to examine the gender difference in fear response and its extinction, and the effect of social interaction for the therapy results. From the clinical point of view, by surveying high school students, female students showed more depressive mood and social anxiety than male students. We developed a new CBT protocol for the adolescent female depression.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (21 results)

All 2014 2013 2012 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (14 results) Remarks (1 results)

  • [Journal Article] Social Skills Training Encourages a Patient with Social Anxiety Disorder to Undertake Challenging Behavioral Experiments2014

    • Author(s)
      Naoki Yoshinaga, Eiji Shimizu
    • Journal Title

      British Journal of Medicine and Medical Research

      Volume: 4 Issue: 3 Pages: 905-913

    • DOI

      10.9734/bjmmr/2014/5612

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cognitive Behaviour Therapy Using the Clark & Wells Model : A Case Study of a Japanese Social Anxiety Disorder Patient2013

    • Author(s)
      Naoki Yoshinaga, Osamu Kobori, Msaomi Iyo, Eiji Shimizu
    • Journal Title

      The Cognitive Behaviour Therapist

      Volume: 6

    • DOI

      10.1017/s1754470x13000081

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Transient Fear Reduction by Pair-Exposure with a Non-Fearful Partner during Fear Extinction Independent from Corticosterone Level in Mice2013

    • Author(s)
      Tomizawa H, Matsuzawa D, Matsuda S, et al.
    • Journal Title

      Journal of Behavioral and Brain Science

      Volume: 3 Issue: 05 Pages: 415-421

    • DOI

      10.4236/jbbs.2013.35043

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Perinatal exposure to bisphenol A enhances contextual fear memory and affects the serotoninergic system in juvenile female mice2013

    • Author(s)
      Matsuda S, et al.
    • Journal Title

      Hormones and behavior

      Volume: 63 Issue: 5 Pages: 709-716

    • DOI

      10.1016/j.yhbeh.2013.03.016

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of perinatal exposure to low dose of bisphenol A on anxiety like behavior and dopamine metabolites in brain2012

    • Author(s)
      Matsuda S, et al.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: 39 Issue: 2 Pages: 273-279

    • DOI

      10.1016/j.pnpbp.2012.06.016

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] No erasure effect of retrieval-extinction trial on fear memory in the hippocampus-independent and dependent paradigms2012

    • Author(s)
      Ishii D, Matsuzawa D, Matsuda S, et al.
    • Journal Title

      Neurosci Lett

      Volume: 523 Issue: 1 Pages: 76-81

    • DOI

      10.1016/j.neulet.2012.06.048

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Sex Differences in Effect of Consecutive Fear Ex on Spontaneous Recovery2013

    • Author(s)
      Matsuda S, Matsuzawa D, Ishii D, Tomizawa H, Sutoh C, Shimizu E
    • Organizer
      Society for Neuroscience 43rd Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2013-11-09
    • Related Report
      2013 Final Research Report
  • [Presentation] Individual Cognitive Behavior Therapy for Japanese Patients with Social Anxiety Disorder : Preliminary Outcomes and Their Predictors2013

    • Author(s)
      Yoshinaga N, Matsuki S, Kobori O, Shimizu E
    • Organizer
      43rd Annual Congress of The European Association for Behavioural and Cognitive Therapies
    • Place of Presentation
      Marrakech, Morocco
    • Year and Date
      2013-09-27
    • Related Report
      2013 Final Research Report
  • [Presentation] A Feasibility Study of Individual Cognitive Behavior Therapy for Social Anxiety Disorder in Japanese2013

    • Author(s)
      Yoshinaga N, Ohshima F, Matsuki S, Tanaka M, Kobayashi T, Ibuki H, Asano K, Kobori O, Shiraishi T, Ito E, Nakazato M, Nakagawa A, Iyo M, Shimizu E
    • Organizer
      Clinical Settings 7th World Congress of Cognitive and Behavioural
    • Place of Presentation
      Therapies Lima, Peru
    • Year and Date
      2013-07-24
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of adult ovariectomy on fear extinction and recovery2013

    • Author(s)
      Matsuda S, Matsuzawa D, Ishii D, Tomizawa H, Shimizu E
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2013-06-22
    • Related Report
      2013 Final Research Report
  • [Presentation] Sex Differences in Effect of Consecutive Fear Ex on Spontaneous Recovery.2013

    • Author(s)
      Matsuda S, Matsuzawa D, Ishii D, Tomizawa H, Sutoh C, Shimizu E.
    • Organizer
      Society for Neuroscience 43rd Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Individual Cognitive Behavior Therapy for Japanese Patients with Social Anxiety Disorder: Preliminary Outcomes and Their Predictors.2013

    • Author(s)
      Yoshinaga N, Matsuki S, Kobori O, Shimizu E.
    • Organizer
      43rd Annual Congress of The European Association for Behavioural and Cognitive Therapies
    • Place of Presentation
      Marrakech, Morocco
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effects of adult ovariectomy on fear extinction and recovery2013

    • Author(s)
      Matsuda S, Matsuzawa D, Ishii D, Tomizawa H, Shimizu E.
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都国際会館
    • Related Report
      2013 Annual Research Report
  • [Presentation] A Feasibility Study of Individual Cognitive Behavior Therapy for Social Anxiety Disorder in Japanese Clinical Settings2013

    • Author(s)
      Yoshinaga N, Ohshima F, Matsuki S, Tanaka M, Kobayashi T, Ibuki H, Asano K, Kobori O, Shiraishi T, Ito E, Nakazato M, Nakagawa A, Iyo M, Shimizu E.
    • Organizer
      7th World Congress of Cognitive and Behavioural Therapies
    • Place of Presentation
      Lima, Peru
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effect of brain development during adolescence on recovery of fear Society for Neuroscience2012

    • Author(s)
      Ishii D, Matsuzawa D, Matsuda S, Tomizawa H, Sutoh C, Shimizu E
    • Organizer
      42th Annual Meeting
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2012-10-15
    • Related Report
      2013 Final Research Report
  • [Presentation] No erasure effect of retrieval-extinction trial on fear memory2012

    • Author(s)
      Ishii D, Matsuzawa D, Matsuda S, Tomizawa H, Sutoh C, Shimizu E
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2012-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of non-fearful partner on fear extinction memory and corticosterone level2012

    • Author(s)
      Tomizawa H, Matsuzawa D, Matsuda S, Ishii D, Sutoh C, Shimizu E
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2012-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Effect of brain development during adolescence on recovery of fear

    • Author(s)
      Ishii D, Matsuzawa D, Matsuda S, Tomizawa H, Sutoh C, Shimizu E
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      New Orleans,USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Sex differences in fear extinction under isolation stress

    • Author(s)
      Matsuda S, Matsuzawa D, Ishii D, Tomizawa H, Sutoh C, Shimizu E.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      New Orleans,USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Effects of non-fearful partner on fear extinction memory and corticosterone level

    • Author(s)
      Tomizawa H, Matsuzawa D, Matsuda S, Ishii D, Sutoh C, Shimizu E
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Remarks] 千葉大学大学院医学研究院認知行動生理学 ホームページ(業績欄)

    • URL

      http://www.m.chiba-u.ac.jp/class/phys1/result/result.html

    • Related Report
      2013 Final Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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