Improvement of Social Cognition Employing Real-time fMRI-based Neuro-feedback

• Project/Area Number: 24659546
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Tamagawa University
• Principal Investigator: MATSUDA TETSUYA 玉川大学, 脳科学研究所, 准教授 (30384720)
• Co-Investigator(Kenkyū-buntansha): OKUBO Yoshiro 日本医科大学, 医学研究科, 教授 (20213663)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 精神科リハビリテーション / ニューロフィードバック / リアルタイムfMRI

Research Abstract

Neuro-feedback refers to the method whereby a subject monitors his/her own neural activity in a particular brain region of interest, and gains the ability to willfully control the level of neural activity. Recently, self-monitoring of neural activity in subcortical and other deep brain areas, as well as areas related to higher-order brain function, became possible with the development of real-time fMRI. The purpose of this research is to develop the task of improvement of social cognition employing real-time fMRI-based neuro-feedback.
It is evident that pervasive developmental disorders (PDD) subjects are able to increase amygdala activity through neuro-feedback training, and that in order to willfully control amygdala activity, simultaneous activity in the insula and MPFC are necessary. Moreover, after the neuro-feedback training, the neural sensitivity of amygdala is increased.

Research Products

• [Journal Article] How Sound Symbolism Is Processed in the Brain, A Study on Japanese Mimetic Words (2014)
  • Author(s): Kanero, J., Imai, M., Okuda, J., Okada, H., Matsuda, T.
  • Journal Title: PLoS ONE Volume: Vol.9(5) Issue: 5 Pages: 1-8
  • DOI: 10.1371/journal.pone.0097905
  • NAID: 40020588051
  • Peer Reviewed / Open Access
• [Journal Article] Changing the mind? Not really -activity and connectivity in the caudate correlates with changes of choice. (2014)
  • Author(s): Ito T, Wu DA, Marutani T, Yamamoto M, Suzuki H, Shimojo S, Matsuda T.
  • Journal Title: Soc Cogn Affect Neurosci Volume: 印刷中 Issue: 10 Pages: 1546-1551
  • DOI: 10.1093/scan/nst147
  • Peer Reviewed
• [Journal Article] How sound symbolism is processed in the brain: A study on Japanese mimetic words. (2014)
  • Author(s): Kanero J, Imai M, Okuda J, Okada H, Matsuda T.
  • Journal Title: Plos One Volume: 印刷中
  • Peer Reviewed
• [Journal Article] リアルタイムfMRIによるニューロフィードバックの基礎とその応用 (2013)
  • Author(s): 土師知己、松田哲也
  • Journal Title: 精神科 Volume: 22(4) Pages: 375-381
• [Presentation] Neural activity modulation employing Real-time fMRI based Neuro-feedback (2014)
  • Author(s): Matsuda T. Haji T
  • Organizer: International Conference of Clinical Neuroscience
  • Place of Presentation: ドイツ(ベルリン)
• [Presentation] Neural activity modulation employing Real-time fMRI-based Neuro-feedback (2014)
  • Author(s): Matsuda T, Haji T
  • Organizer: International Conference of Clinical Neuroscience
  • Place of Presentation: ドイツ（ベルリン）
• [Presentation] 科学技術の将来ビジョンについて (2013)
  • Author(s): 松田哲也
  • Organizer: 第90回日本生理学会
  • Place of Presentation: 東京都
  • Year and Date: 2013-03-29
• [Presentation] 社会神経科学研究の今後の方向性 (2013)
  • Author(s): 松田哲也
  • Organizer: 第2回社会神経科学研究会
  • Place of Presentation: 岡崎コンファレンスセンター(愛知県)
  • Year and Date: 2013-01-31
• [Presentation] 社会神経科学研究の今後の方向性
  • Author(s): 松田哲也
  • Organizer: 第2回社会神経科学研究会
  • Place of Presentation: 岡崎コンファレンスセンター（愛知県）
  • Invited
• [Presentation] 科学技術の将来ビジョンについて
  • Author(s): 松田哲也
  • Organizer: 第90回日本生理学会
  • Place of Presentation: タワーホール船堀（東京）
  • Invited