Analyses of dopamine-independent brain functions with dopamine deficient mice.
Project/Area Number |
24659549
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Psychiatric science
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Research Institution | Tokyo Metropolitan Institute of Medical Science |
Principal Investigator |
IKEDA Kazutaka 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 参事研究員 (60281656)
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Co-Investigator(Kenkyū-buntansha) |
KASAI Shinya 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 主席研究員 (20399471)
FUJITA Masayo 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 主席研究員 (90415539)
萩野 洋子 公益財団法人東京都医学総合研究所, その他部局等, 研究員 (40332382)
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Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
Keywords | 医療・福祉 / 生理活性 / 神経科学 / 脳・神経 / 薬理学 |
Outline of Final Research Achievements |
Dopaminergic systems have been known to be involved in the regulation of locomotor activity and development of psychosis. The present study showed that dopamine-deficient (DD) mice, which had received daily L-DOPA injections, could move effectively and even be hyperactive 72 h after the last L-DOPA injection when dopamine was almost completely depleted. Such hyperactivity was ameliorated by clozapine but not haloperidol or ziprasidone. Among multiple actions of clozapine, muscarinic acetylcholine (ACh) activation markedly reduced locomotor activity in DD mice. Furthermore, the expression of choline acetyltransferase, an ACh synthase, was reduced and extracellular ACh levels were significantly reduced in DD mice. These results suggest that the cholinergic system, in addition to the dopaminergic system, may be involved in motor control, including hyperactivity and psychosis.
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Report
(4 results)
Research Products
(182 results)
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[Journal Article] Association between the rs1465040 single-nucleotide polymorphism close to the transient receptor potential subfamily C member 3 (TRPC3) gene and postoperative analgesic requirements.2015
Author(s)
Aoki Y, Nishizawa D, Hasegawa J, Kasai S, Yoshida K, Koukita Y, Ichinohe T, Nagashima M, Katoh R, Satoh Y, Tagami M, Hayashida M, Fukuda K, Ikeda K.
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Journal Title
J Pharmacol Sci
Volume: 127
Issue: 3
Pages: 391-393
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Attenuated methamphetamine-induced locomotor sensitization in serotonin transporter knockout mice is restored by serotonin 1B receptor antagonist treatment.2015
Author(s)
Igari M, Shen H, Hagino Y, Fukushima S, Kasahara Y, Lesch K, Murphy D, George R Uhl, Ikeda K, Yaegashi N, Sora I
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Journal Title
Behav Pharmacol
Volume: 26
Issue: 1 and 2 - Special Issue
Pages: 167-179
DOI
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Peer Reviewed
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[Journal Article] Association Between <i>KCNJ6</i> (<i>GIRK2</i>) Gene Polymorphism rs2835859 and Post-operative Analgesia, Pain Sensitivity, and Nicotine Dependence2014
Author(s)
Nishizawa D, Fukuda K, Kasai S, Ogai Y, Hasegawa J, Sato N, Yamada H, Tanioka F, Sugimura H, Hayashida M, Ikeda K.
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Journal Title
Journal of Pharmacological Sciences
Volume: 126
Issue: 3
Pages: 253-263
DOI
NAID
ISSN
1347-8613, 1347-8648
Related Report
Peer Reviewed / Open Access
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[Journal Article] Haplotype analysis of GSK-3beta gene polymorphisms in bipolar disorder lithium responders and non-responders.2014
Author(s)
Iwahashi K, Nishizawa D, Narita S, Numajiri M, Murayama O, Yoshihara E, Onozawa Y, Nagahori K, Fukamauchi F, Ikeda K, Ishigooka J
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Journal Title
Clin Neuropharmacol
Volume: 37
Issue: 4
Pages: 108-110
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Association between genetic polymorphism rs2952768, close to the METTL21A and CREB1 genes, and intellectual ability in healthy subjects2014
Author(s)
Nishizawa D, Ohi K, Hashimoto R, Yamamori H, Yasuda Y, Fujimoto M, Umeda-Yano S, Takeda M, Ikeda K
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Journal Title
Journal of Addiction Research & Therapy
Volume: 5(2)
Issue: 02
Pages: 1000178-1000178
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] 物質関連障害および嗜癖性障害群.2014
Author(s)
宮田久嗣, 樋口進, 廣中直行, 池田和隆, 伊豫雅臣, 小宮山徳太郎, 松本俊彦, 鈴木勉, 高田孝二, 和田清, 齋藤利和
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Journal Title
精神神経学雑誌
Volume: 116(11)
Pages: 950-954
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[Journal Article] Haplotype analysis of GSK-3beta gene polymorphisms in bipolar disorder lithium responders and non-responders.2014
Author(s)
Iwahashi K, Nishizawa D, Narita S, Numajiri M, Murayama O, Yoshihara E, Onozawa Y, Nagahori K, Fukamauchi F, Ikeda K, Ishigooka J
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Journal Title
Clinical Neuropharmacology
Volume: -
Related Report
Peer Reviewed
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[Journal Article] Genome-wide association study identifies a potent locus associated with human opioid sensitivity.2014
Author(s)
Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Aoki Y, Nishi A, Saita N, Koukita Y, Nagashima M, Katoh R, Satoh Y, Tagami M, Higuchi S, Ujike H, Ozaki N, Inada T, Iwata N, Sora I, Iyo M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Itokawa M, Koga M, Arinami T, Kaneko Y, Hayashida M, Ikeda K.
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Journal Title
Mol Psychiatry
Volume: 19(1)
Issue: 1
Pages: 55-62
DOI
Related Report
Peer Reviewed
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[Journal Article] Involvement of the N-methyl-D-aspartate receptor GluN2D subunit in phencyclidine-induced motor impairment, gene expression, and increased Fos immunoreactivity2013
Author(s)
Hideko Yamamoto, Etsuko Kamegaya, Wakako Sawada, Ryota Hasegawa, Toshifumi Yamamoto, Yoko Hagino, Yukio Takamatsu, Kazuhide Imai, Hisashi Koga, Masayoshi Mishina and Kazutaka Ikeda
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Journal Title
Molecular Brain
Volume: 6
Issue: 1
Pages: 56-56
DOI
Related Report
Peer Reviewed
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[Journal Article] Functional analysis of deep intronic SNP rs13438494 in intron 24 of PCLO gene2013
Author(s)
Seo S, Takayama K, Uno K, Ohi K, Hashimoto R, Nishizawa D, Ikeda K, Ozaki N, Nabeshima T, Miyamoto Y, Nitta A
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Journal Title
PLoS ONE
Volume: 8(10)
Issue: 10
Pages: e76960-e76960
DOI
Related Report
Peer Reviewed
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[Journal Article] Association between dopamine beta hydroxylase rs5320 polymorphism and smoking behaviour in elderly Japanese2012
Author(s)
Ella E, Sato N, Nishizawa D, Kageyama S, Yamada H, Kurabe N, Ishino K, Tao H, Tanioka F, Nozawa A, Chen R, Shinmura K, Ikeda K, Sugimura H
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Journal Title
J Hum Genet
Volume: 57
Issue: 6
Pages: 385-390
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] Specific regions display altered grey matter volume in mu-opioid receptor knockout mice: mri voxel-based morphometry.2014
Author(s)
Sora I, Sasaki K, Sumiyoshi A, Nonaka H, Kasahara Y, Ikeda K, Hall FS, Uhl GR, Watanabe M, Kawashima R
Organizer
The 53rd Annual Meeting of American College of Neuropsychopharmacology (ACNP 53rd Annual Meeting)
Place of Presentation
Phoenix, USA
Year and Date
2014-12-07 – 2014-12-11
Related Report
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[Presentation] Differences in responsiveness between methamphetamine, nisoxetine and methylphenidate may reflect specific developmental characteristics in juvenile DAT KO mice.2014
Author(s)
Kubo Y, Kasahara Y, Arime Y, Hall FS, Takamatsu Y, Ikeda K, Uhl GR, Sora I, Tomita H
Organizer
Society for Neuroscience 2014
Place of Presentation
Washington DC, USA
Year and Date
2014-11-15 – 2014-11-19
Related Report
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[Presentation] PCLO SNP rs13438494 regulates DA and 5-HT uptake, accompanied with splicing efficiency and dependence-like behaviors in genomic association studies.2014
Author(s)
Uno K, Nishizawa D, Seo S, Sasaki N, Ohi K, Nabeshima T, Hashimoto R, Ozaki N, Ikeda K, Miyamoto Y, Nitta A
Organizer
29th CINP World Congress of Neuropsychopharmacology
Place of Presentation
Vancouver, Canada
Year and Date
2014-06-24
Related Report
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[Presentation] Associations of an orexin (hypocretin) receptor 2 gene polymorphism with nicotine dependence found in genome-wide and following association studies.2014
Author(s)
Nishizawa D, Kasai S, Hasegawa J, Sato N, Tanioka F, Nagashima M, Ujike H, Hashimoto R, Tanaka M, Sugimura H, Ikeda K
Organizer
29th CINP World Congress of Neuropsychopharmacology
Place of Presentation
Vancouver, Canada
Year and Date
2014-06-23
Related Report
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[Presentation] Personalized pain control.2014
Author(s)
Ikeda K, Nishizawa D, Hayashida M, Fukuda K
Organizer
2014 YONSEI BK21 PLUS-IGAKUKEN Joint Symposium
Place of Presentation
Soul, Korea
Year and Date
2014-06-20
Related Report
Invited
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[Presentation] Genome-wide association study identifies a potent locus associated with human opioid sensitivity.2013
Author(s)
Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Nagashima M, Satoh Y, Higuchi S, Ujike H, Arinami T, Hayashida M, Ikeda K
Organizer
XXIst World Congress of Psychiatric Genetics(WCPG2013:第21回精神科遺伝学国際会議)
Place of Presentation
Boston, USA
Related Report
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[Presentation] Genome-wide association study identifies a potent locus associated with human opioid sensitivity.2013
Author(s)
Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Aoki Y, Nishi A, Saita N, Koukita Y, Nagashima M, Katoh R, Satoh Y, Tagami M, Higuchi S, Ujike H, Ozaki N, Inada T, Iwata N, Sora I, Iyo M, Kondo N, Won MJ, Naruse N, Uehara K, Itokawa M, Koga M, Arinami T, Kaneko Y, Hayashida M, Ikeda K
Organizer
European Human Genetics Conference 2013
Place of Presentation
Paris, Franc
Related Report
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[Presentation] 精神疾患に関連するPCLO SNP rs13438494の分子生物学的検討.
Author(s)
宇野恭介, 徐承姫, 松村祥平, 大井一高, 橋本亮太, 西澤大輔, 池田和隆, 酒井規雄, 鍋島俊隆, 宮本嘉明, 新田淳美
Organizer
第23回日本臨床精神神経薬理学会・第43回日本神経精神薬理学会合同年会
Place of Presentation
宜野湾
Related Report
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[Presentation] A randomized, rater blinded, crossover study of ifenprodil effect on relapse risk in patients with alcohol dependence.
Author(s)
Sugaya N, Ogai Y, Aikawa Y, Yumoto Y, Takahama M, Tanaka M, Haraguchi A, Umeno M, Ikeda K
Organizer
CINP Special Congress on Addiction and Mental Health
Place of Presentation
Kuala Lumpur, Malaysia
Related Report
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[Presentation] Increased regional gray matter volume in the mu-opioid receptor knockout mice determined by mri voxel-based morphometry.
Author(s)
Sasaki K, Sumiyoshi A, Nonaka H, Hall FS, Uhl GR, Watanabe M, Kasahara Y, Ikeda K, Kawashima R, Sora I
Organizer
INRC2013
Place of Presentation
Cairns, Australia
Related Report
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[Presentation] セロトニンおよびドパミントランスポーターを過剰発現させたPC12およびHEK293細胞において、PCLOのSNPはモノアミン取り込みを制御する.
Author(s)
宇野恭介, 高山佳奈子, 徐承姫, 大井一高, 橋本亮太, 西澤大輔, 池田和隆, 酒井規雄, 鍋島俊隆, 宮本嘉明, 新田淳美
Organizer
Neuro2013
Place of Presentation
京都
Related Report
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