| Project/Area Number |
24659550
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
YOSHINAGA Keiichiro 北海道大学, 医学(系)研究科(研究院), 客員研究員 (30435961)
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| Co-Investigator(Kenkyū-buntansha) |
KATOH Chietugu 北海道大学, 大学院保健科学研究院, 教授 (10292012)
YAMADA Satoshi 北海道大学, 北海道大学病院, 助教 (80374320)
NISHIDA Mutsumi 北海道大学, 北海道大学病院, 副臨床検査技師長 (90404722)
NISHIO Saori 北海道大学, 北海道大学病院, 助教 (90463736)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | オシロメトリック法 / 動脈硬化 / 血管内皮機能 / 血管径 / 超音波検査 / 血管機能 / 超音波 / 血管内皮 / 血管弾性率 / 内科系臨床医学 / 放射線科学 / 画像診断学 |
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| Outline of Final Research Achievements |
Background: We aimed to investigate whether VE and eA response to nitroglycerin (NTG) reflected endothelial and endothelial independent dysfunction related to chronic kidney disease (CKD). Methods: 13 CKD and 15 controls were studied. Rest VE and eA response to NTG were measured by novel automated oscillometric detector. eA was estimated using pressure-volume curves and VE was defined as follows [VE=ΔPressure/ (100XΔarea/Area) mmHg/%]. Ultrasound measurements of flow mediated vasodilatation (FMD) and NTG were used as standard.Results: Rest eA and VE showed good reproducibility (eA: ICC = 0.88, VE: ICC = 0 .78). Rest Ve was negatively correlated with %FMD(r=-0.43, P=0.02). Conclusions: This new automated vascular function measurement using oscillometric measurement reliably detected endothelial dysfunction related to CKD and has potential to detect endothelial independent vasodilator response.
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