Development of physiological vascular function measurements
| Project/Area Number |
24659550
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
YOSHINAGA Keiichiro 北海道大学, 医学(系)研究科(研究院), 客員研究員 (30435961)
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| Co-Investigator(Kenkyū-buntansha) |
KATOH Chietugu 北海道大学, 大学院保健科学研究院, 教授 (10292012)
YAMADA Satoshi 北海道大学, 北海道大学病院, 助教 (80374320)
NISHIDA Mutsumi 北海道大学, 北海道大学病院, 副臨床検査技師長 (90404722)
NISHIO Saori 北海道大学, 北海道大学病院, 助教 (90463736)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | オシロメトリック法 / 動脈硬化 / 血管内皮機能 / 血管径 / 超音波検査 / 血管機能 / 超音波 / 血管内皮 / 血管弾性率 / 内科系臨床医学 / 放射線科学 / 画像診断学 |
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| Outline of Final Research Achievements |
Background: We aimed to investigate whether VE and eA response to nitroglycerin (NTG) reflected endothelial and endothelial independent dysfunction related to chronic kidney disease (CKD). Methods: 13 CKD and 15 controls were studied. Rest VE and eA response to NTG were measured by novel automated oscillometric detector. eA was estimated using pressure-volume curves and VE was defined as follows [VE=ΔPressure/ (100XΔarea/Area) mmHg/%]. Ultrasound measurements of flow mediated vasodilatation (FMD) and NTG were used as standard.Results: Rest eA and VE showed good reproducibility (eA: ICC = 0.88, VE: ICC = 0 .78). Rest Ve was negatively correlated with %FMD(r=-0.43, P=0.02). Conclusions: This new automated vascular function measurement using oscillometric measurement reliably detected endothelial dysfunction related to CKD and has potential to detect endothelial independent vasodilator response.
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Report
(4 results)
Research Products
(11 results)
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[Presentation] Novel simple and accurate quantitative endothelial function measurements using brachial artery vascular volume elastic modulus with automated oscillometric approach.2014
Author(s)
12.Yoshinaga K, Tomiyama Y, Fujii S, Nishio S, Matsuoka N, Ochi N, Katoh C, Inoue M, Nishida M, Ito YM, Nishibayashi H, Tamaki N
Organizer
87th American Heart Association (AHA) Scientific Sessions
Place of Presentation
Chicago, IL(USA)
Year and Date
2014-11-15 – 2014-11-19
Related Report
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