Characterization of malignant glioma and development of potent treatment strategy focusing on hypoxia dynamics
| Project/Area Number |
24659551
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
INANAMI Osamu 北海道大学, (連合)獣医学研究科, 教授 (10193559)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMORI Tohru 北海道大学, 大学院獣医学研究科, 准教授 (00512675)
YASUI Hironobu 北海道大学, 大学院獣医学研究科, 助教 (10570228)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 脳腫瘍 / 低酸素 / イメージング / 放射線治療 / 核医学イメージング / 電子スピン共鳴 / 間欠的低酸素 / グリオーマ / 放射線 / PET / 微小環境 |
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| Research Abstract |
The purpose of this study is to clarify the hypothesis that the frequency of tumor hypoxia influences the prognosis of malignant glioma rather than an amount of tumor hypoxia. The results revealed that sequential PET analysis using 18F-FMISO could not visualize the transient hypoxia in glioma, because it took the relatively long time for the radioactivity attenuation. However, this study achieved the establishment of hypoxia imaging in transplanted murine glioma by using electron spin resonance technique. Furthermore, it was revealed that doranidazole is a potent drug to improve the radiation efficiency against hypoxic glioma cells.
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Report
(3 results)
Research Products
(90 results)
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[Journal Article] Radiosensitization of tumor cells through endoplasmic reticulum stress induced by PEGylated nanogel containing gold nanoparticles2014
Author(s)
Yasui H., Takeuchi R., Nagane M., Meike S., Nakamura Y., Yamamori T., Ikenaka Y., Kon Y., Murotani H., Oishi M., Nagasaki Y., and Inanami O
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Journal Title
Cancer Lett
Volume: 347(1)
Pages: 151-158
NAID
Related Report
Peer Reviewed
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[Journal Article] Radiosensitization of tumor cells through endoplasmic reticulum stress induced by PEGylated nanogel containing gold nanoparticles.2014
Author(s)
Yasui H, Takeuchi R, Nagane M, Meike S, Nakamura Y, Yamamori T, Ikenaka Y, Kon Y, Murotani H, Oishi M, Nagasaki Y, Inanami O
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Journal Title
Cancer Letters
Volume: 347
Issue: 1
Pages: 151-158
DOI
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] EPR oxygen imaging and hyperpolarized (13) C MRI of pyruvate metabolism as noninvasive biomarkers of tumor treatment response to a glycolysis inhibitor 3-bromopyruvate2013
Author(s)
Matsumoto S., Saito K., Yasui H., Morris H.D., Munasinghe J.P., Lizak M., Merkle H., Ardenkjaer-Larsen J.H., Choudhuri R., Devasahayam N., Subramanian S., Koretsky A.P., Mitchell J.B., and Krishna M.C
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Journal Title
Magn. Reson. Med
Volume: 69(5)
Pages: 1443-1450
Related Report
Peer Reviewed
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[Journal Article] Reoxygenation-induced nitric oxide mitigates tumor hypoxia and radioresistance in a murine SCCVII tumor model2013
Author(s)
Nagane M, Yasui H, Yamamori T, Zhao S, Kuge Y, Tamaki N, Kameya H, Nakamura H, Fujii H, Hirata H, Inanami O
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Journal Title
Biochem Biophys Res Commun
Volume: 437
Issue: 3
Pages: 420-425
DOI
Related Report
Peer Reviewed
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[Journal Article] Roles of mitochondria-generated reactive oxygen species on X-ray-induced apoptosis in a human hepatocellular carcinoma cell line2012
Author(s)
Indo H.P., Inanami O., Koumura T., Suenaga S., Yen H.C., Kakinuma S., Matsumoto K., Nakanishi I., St. Clair W., St. Clair D.K., Matsui H., Cornette R., Gusev O., Okuda T., Nakagawa Y., Ozawa T., and Majima H.J
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Journal Title
HLE. Free Radic. Res
Volume: 46(8)
Pages: 1029-1043
Related Report
Peer Reviewed
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[Journal Article] Roles of mitochondria-generated reactive oxygen species on X-ray-induced apoptosis in a human hepatocellular carcinoma cell line, HLE.2012
Author(s)
Indo HP, Inanami O, Koumura T, Suenaga S, Yen H-C, Kakinuma S, Matsumoto K, Nakanishi I, St Clair W, St Clair DK, Matsui H, Cornette R, Gusev O, Okuda T, Nakagawa Y, Ozawa T & Majima HJ
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Journal Title
Free Radical Research
Volume: Vol. 46, No. 8
Issue: 8
Pages: 1029-1043
DOI
Related Report
Peer Reviewed
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[Presentation] In vivo tumor extracellular pH monitoring using electron paramagnetic resonance2013
Author(s)
Goodwin J., Yachi K., Nagane M., Yasui H., Miyake Y., Inanami O., Bobko AA., Khramtsov V., Hirata H
Organizer
41st Annual ISOTT Meeting & EPR 2013
Place of Presentation
the Hanover Inn (Hanover, NH, USA)
Related Report
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[Presentation] がんの放射線治療効率化に向けたESR技術の適用2012
Author(s)
○安井博宣, 松元慎吾, 伊藤慎治, 山盛徹, 兵藤文紀, 市川和洋, 中村秀夫, 内海英雄, Krishna M.C., 稲波修.
Organizer
第51回電子スピンサイエンス学会年会シンポジウム
Place of Presentation
札幌コンベンションセンター (札幌市, 北海道)
Related Report
Invited
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