| Project/Area Number |
24659551
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
INANAMI Osamu 北海道大学, (連合)獣医学研究科, 教授 (10193559)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMORI Tohru 北海道大学, 大学院獣医学研究科, 准教授 (00512675)
YASUI Hironobu 北海道大学, 大学院獣医学研究科, 助教 (10570228)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 脳腫瘍 / 低酸素 / イメージング / 放射線治療 / 核医学イメージング / 電子スピン共鳴 / 間欠的低酸素 / グリオーマ / 放射線 / PET / 微小環境 |
|---|
| Research Abstract |
The purpose of this study is to clarify the hypothesis that the frequency of tumor hypoxia influences the prognosis of malignant glioma rather than an amount of tumor hypoxia. The results revealed that sequential PET analysis using 18F-FMISO could not visualize the transient hypoxia in glioma, because it took the relatively long time for the radioactivity attenuation. However, this study achieved the establishment of hypoxia imaging in transplanted murine glioma by using electron spin resonance technique. Furthermore, it was revealed that doranidazole is a potent drug to improve the radiation efficiency against hypoxic glioma cells.
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