Protective effects of a combination of multiple pharmaceutical drugs on the survival of mice exposed to lethal ionizing radiation
| Project/Area Number |
24659553
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MONZEN Satoru 弘前大学, 保健学研究科, 助教 (20514136)
YOSHINO Hironori 弘前大学, 保健学研究科, 助教 (10583734)
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| Co-Investigator(Renkei-kenkyūsha) |
ITO Koichi 弘前大学, 保健学研究科, 教授 (90398579)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 医薬品 / 全身照射 / 急性放射線症候群 / romiprostim |
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| Research Abstract |
Different combinations of four drugs - recombinant human erythropoietin (EPO), granulocyte-colony stimulating factor (G-CSF), c-mpl receptor agonist romiplostim (RP) and nandrolone decanoate (ND)- was administered to mice within 2 h after exposure to a lethal 7 Gy dose of gamma-irradiation.Approximately 10% of the untreated irradiated control mice survived for 27 days, but all of the control mice died by day 30. The combined administration of G-CSF, EPO and RP for three days immediately after irradiation led to a complete survival of the irradiated mice until day 30.However,the treatment with G-CSF and EPO with ND led to only 75% survival at day 30.The hematological analyses showed that the numbers of almost of hematopoietic cells in the surviving mice treated with effective medications recovered to the levels of non-irradiated mice.The present findings show that the combination of G-CSF, EPO and RP may be a useful countermeasure for victims exposed to accidental lethal irradiation.
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Report
(3 results)
Research Products
(14 results)
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[Presentation] 致死線量放射線ばく露マウスに対する C-Mpl作動薬の作用2013
Author(s)
石川純也,廣内篤久,伊藤巧一,千葉満,中野学,門前暁,吉野浩教,羽澤勝治,中野光,山口平,田中公夫,柏倉幾郎
Organizer
日本放射線影響学会第56回大会
Place of Presentation
青森市
Year and Date
2013-10-18
Related Report
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