Basic research on Sophistication of Medical Si/CdTe compton camera

• Project/Area Number: 24659557
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Gunma University
• Principal Investigator: NAKANO Takashi 群馬大学, 医学(系)研究科(研究院), 教授 (20211427)
• Co-Investigator(Kenkyū-buntansha): SHIMADA Hirohumi 群馬大学, 重粒子線医学推進機構, 助教 (10414575) ; KATO Hiroyuki 群馬大学, 重粒子線医学推進機構, 助教 (30334121) ; SUZUKI Yoshiyuki 群馬大学, 大学院医学系研究科, 准教授 (60334116) ; YOSHIDA Yukari 群馬大学, 重粒子線医学推進機構, 助教 (90431717) ; TORIKAI Kouta 群馬大学, 先端科学研究指導者育成ユニット, 助教 (90443077)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: コンプトンカメラ / 粒子線治療 / 核医学診断 / 国際研究者交流

Research Abstract

We developed Si/CdTe Compton camera for medical use which can measure gannma-rays from the Tc-99m up to F-18. Then, we succeeded simultaneously to measure two types of RI distributions of F-18FDG and I-133 and to obtain three-dimensional imaging of the two RI distribution administered to a rat.
We succeeded to conduct clinical study of administration of 18F-FDG and 99mTc-DMSA, drugs for nuclear medicine diagnostic, in a human to obtain simultaneous imaging of the two RI by the clinical Si/CdTe Compton camera first in the world. In clinical, by simultaneous measurement method by multiple RI drugs, a significant reduction in testing time is expected. In addition, the development of RI diagnostic techniques of tracing simultaneous disposition of multiple RI drugs is expected to lead to the creation of a new scientific area such as bio-dynamics study by the tracing and the study to clarify the mechanisms of malignant transformation of cancer cells.

Research Products

• [Journal Article] Three-dimensional and multienergy gamma-ray simultaneous imaging by using a Si/CdTe Compton camera (2013)
  • Author(s): Suzuki Y, Yamaguchi M, Odaka H, Shimada H, Yoshida Y, Torikai K, Satoh T, Arakawa K, Kawachi N, Watanabe S, Takeda S, Ishikawa SN, Aono H, Watanabe S, Takahashi T, Nakano T
  • Journal Title: Radiology Volume: 267(3) Pages: 941-7
• [Journal Article] Beam range estimation by measuring bremsstrahlung (2012)
  • Author(s): Yamaguchi M, Torikai K, Kawachi N, Shimada H, Satoh T, Nagao Y, Fujimaki S, Kokubun M, Watanabe S, Takahashi T, Arakawa K, Kamiya T, Nakano T
  • Journal Title: Phys Med Biol Volume: 57(10) Pages: 2843-56
• [Journal Article] Applications and Imaging Techniques of a Si/CdTe Compton Gamma-Ray Camera (2012)
  • Author(s): Takeda, S., Ichinohe, Y., Hagino, K., Odaka, H., Yuasa, T., Ishikawa, Shinya Saito, Tamotsu Satoa, Goro Sato, Shin Watanabe, Motohide Kokubun, Tadayuki Takahashi, Mitsutaka Yamaguchi, Hiroyasu Tajima, Takaaki Tanaka, Kazuhiro Nakazawa, Yasushi Fukazawa, Nakano, T
  • Journal Title: Physics Procedia Volume: 37 Pages: 859-66
• [Journal Article] Use of FDG-PET in Radiation Treatment Planning for Thoracic Cancers. (2012)
  • Author(s): Shirai K, Nakagawa A, Abe T, Kawahara M, Saitoh J, Ohno T, Nakano T.
  • Journal Title: Int J Mol Imaging Volume: 2012 Pages: 1-9
• [Journal Article] Differential Bystander Signaling Between Radioresistant Chondrosarcoma Cells and Fibroblasts After X-Ray, Proton, Iron Ion and Carbon Ion Exposures (2012)
  • Author(s): Wakatsuki M, Magpayo N, Kawamura H, Held KD.
  • Journal Title: Int J Radiat Oncol Biol Phys. Volume: 2012 Pages: 1-6
• [Journal Article] Usefulness of double dose contrast-enhanced magnetic resonance imaging for clear delineation of gross tumor volume in stereotactic radiotherapy treatment planning of metastatic brain tumors: a dose comparison study. (2012)
  • Author(s): Subedi KS, Takahashi T, Yamano T, Saitoh JI, Nishimura K, Suzuki Y, Ohno T, Nakano T.
  • Journal Title: J Radiat Res. Volume: 2012 Pages: 1-5
• [Presentation] 医学用Si/CdTe半導体コンプトンカメラの体幹部における散乱が画質に与える影響 (2014)
  • Author(s): 酒井真理,菊地美貴子,鳥飼幸太,荒川和夫,山口充孝,長尾悠人,河地有木,藤巻秀,神谷富裕,小高裕和,国分紀秀,武田伸一郎,渡辺伸,高橋忠幸,中野隆史
  • Organizer: 第53回日本生体医工学会大会
  • Year and Date: 2014-06-24
• [Presentation] 医学・生物学用マルチヘッドSi/CdTe半導体コンプトンカメラのための横断断層撮像画質のシミュレーションによる評価 (2014)
  • Author(s): 山口充孝,酒井真理,長尾悠人,河地有木,藤巻秀,荒川和夫,神谷富裕,小高裕和,国分紀秀,武田伸一郎,渡辺伸,高橋忠幸,鳥飼幸太,中野隆史
  • Organizer: 第61回応用物理学会春季学術講演会
  • Year and Date: 2014-03-17
• [Presentation] (2014)
  • Author(s): Torikai K., Suzuki Y., Arakawa K., Noda S., Sakai M., Tashiro M., Shimada H., Yoshida Y., Kubota Y., Matsumura A., Saito A., Kanai T., Yamada S., Yamaguchi M., Nagao Y., Kawachi N., Kamiya T., Takahashi T., Takeda S., Watanabe S. and Nakano T
  • Organizer: The 2nd International Symposium of Gunma University Program for Leading Graduate School
  • Year and Date: 2014-01-24
• [Presentation] Carbon beam microsurgery and medical compton camera for next generation microsurgery system (2013)
  • Author(s): Torikai K., Suzuki Y., Arakawa K., Noda S., Sakai M., Tashiro M., Shimada H., Yoshida Y., Kubota Y., Matsumura A., Saito A., Kanai T., Yamada S., Yamaguchi M., Nagao Y., Kawachi N., Kamiya T., Takahashi T., Takeda S., Watanabe S. and Nakano T
  • Organizer: AMDE2013
  • Year and Date: 2013-12-19
• [Presentation] Carbon beam microsurgery and medical compton camera for next generation brain surgery (2013)
  • Author(s): Torikai K., Suzuki Y., Arakawa K., Noda S., Sakai M., Tashiro M., Shimada H., Yoshida Y., Kubota Y., Matsumura A., Saito A., Kanai T., Yamada S., Yamaguchi M., Nagao Y., Kawachi N., Kamiya T., Takahashi T., Takeda S., Watanabe S. and Nakano T
  • Organizer: Brain and Health Informatics 2013
  • Year and Date: 2013-10-29
• [Presentation] Development of a Method Calculating Detection Efficiency Maps for Quantitative Image Reconstruction of a Compton Camera (2013)
  • Author(s): Nagao Y., Yamaguchi, M. Kawachi N., Fujimaki S., Kamiya T., Takeda S., Watanabe S., Takahashi T., Torikai K., Arakawa K., Nakano T
  • Organizer: IEEE NSS/MIC/RTSD
  • Year and Date: 2013-10-27
• [Presentation] A new beam range monitoring method by measuring low energy photons (2013)
  • Author(s): Yamaguchi M., Torikai K., Kawachi N., Shimada H., Satoh T., Nagao Y., Fujimaki S., Kokubun M., Watanabe S., Takahashi T., Arakawa K., Kamiya T., Nakano T
  • Organizer: IEEE NSS/MIC/RTSD
  • Year and Date: 2013-10-27
• [Presentation] An evaluation of three-dimensional imaging by use of Si/CdTe Compton cameras (2013)
  • Author(s): Yamaguchi M., Nagao Y., Kawachi N., Fujimaki S., Kamiya T., Odaka H., Kokubun M., Takeda S., Watanabe S., Takahashi T., Shimada H., Torikai K., Arakawa K., Nakano T
  • Organizer: IEEE NSS/MIC/RTSD
  • Year and Date: 2013-10-27
• [Presentation] 植物体内における複数元素動態の同時撮像技術の開発 (2013)
  • Author(s): 河地有木,鈴井伸郎,石井里美,尹永根,山口充孝,長尾悠人,神谷富裕,高橋忠幸,中野隆史,藤巻秀
  • Organizer: 日本土壌肥料学会2013年度名古屋大会
  • Year and Date: 2013-09-11
• [Presentation] 医学・生物学応用のためのSi/CdTe半導体コンプトンカメラの開発 (2013)
  • Author(s): 山口充孝,長尾悠人,河地有木,藤巻秀,荒川和夫,神谷富裕,小高裕和,国分紀秀,武田伸一郎,渡辺伸,高橋忠幸,鳥飼幸太,島田博文,中野隆史
  • Organizer: 第60回応用物理学会春季学術講演会
  • Year and Date: 2013-03-27
• [Presentation] コンプトンカメラの医学・生物学応用に向けた定量的画像再構成法の開発 (2013)
  • Author(s): 長尾悠人,山口充孝,河地有木,藤巻秀,神谷富裕,武田伸一郎,渡辺伸,高橋忠幸,鳥飼幸太,荒川和夫,中野隆史
  • Organizer: 第60回応用物理学会春季学術講演会
  • Year and Date: 2013-03-27
• [Presentation] Si/CdTeコンプトンカメラによる近接領域におけるガンマ線源強度分布の定量撮像を目的とした画像再構成手法の開発 (2012)
  • Author(s): 長尾悠人,山口充孝,河地有木,藤巻秀,神谷富裕,武田伸一郎,小高裕和,渡辺伸,国分紀秀,高橋忠幸,鳥飼幸太,島田博文,荒川和夫,鈴木義行,中野隆史
  • Organizer: 第14回放射線プロセスシンポジウム
  • Year and Date: 2012-06-28
• [Presentation] 「癌に対する重粒子線治療」 (2012)
  • Author(s): 中野 隆史
  • Organizer: 第34回日本癌局所療法研究会
  • Place of Presentation: 福島
  • Invited
• [Presentation] ｼﾝﾎﾟｼﾞｳﾑII「粒子線治療のための物理学、化学、生物学」 (2012)
  • Author(s): 中野 隆史
  • Organizer: 第41回放射線による制癌シンポジウム
  • Place of Presentation: 沖縄
• [Presentation] 「群馬大学における重粒子線マイクロサージェリィ治療技術の開発について」 (2012)
  • Author(s): 中野 隆史
  • Organizer: 第9回日本粒子線治療臨床研究会
  • Place of Presentation: 鹿児島
• [Presentation] 「日本における粒子線治療の歴史と将来展望」 (2012)
  • Author(s): 中野 隆史
  • Organizer: JASTRO第25回学術大会 三菱主催ランチョンセミナー
  • Place of Presentation: 東京
• [Presentation] Si/CdTeコンプトンカメラによる近接領域におけるガンマ線源強度分布の定量撮像を目的とした画像再構成手法の開発
  • Author(s): 長尾 悠人, 山口 充孝, 河地 有木, 藤巻 秀, 神谷 富裕, 武田 伸一郎, 小高 裕和,渡辺 伸, 国分 紀秀,高橋 忠幸, 鳥飼 幸太, 島田 博文, 荒川 和夫, 鈴木 義行, 中野 隆史
  • Organizer: 第14回放射線プロセスシンポジウム
  • Place of Presentation: 東京大学
• [Presentation] 植物体内における複数元素動態の同時撮像技術の開発,日本土壌肥料学会
  • Author(s): 河地 有木, 鈴井 伸郎, 石井 里美, 尹 永根, 山口 充孝, 長尾 悠人, 神谷 富裕, 高橋 忠幸, 中野 隆史, 藤巻 秀
  • Organizer: 日本土壌肥料学会 2013年度名古屋大会
  • Place of Presentation: 名古屋大学
• [Presentation] Development of a Method Calculating Detection Efficiency Maps for Quantitative Image Reconstruction of a Compton Camera
  • Author(s): Nagao Y., Yamaguchi M., Kawachi N., Fujimaki S., Kamiya T., Takeda S., Watanabe S., Takahashi T., Torikai K., Arakawa K., Nakano T.
  • Organizer: IEEE NSS/MIC/RTSD
  • Place of Presentation: 韓国
• [Presentation] A new beam range monitoring method by measuring low energy photons
  • Author(s): Yamaguchi M., Torikai K., Kawachi N., Shimada H., Satoh T., Nagao Y., Fujimaki S., Kokubun M., Watanabe S., Takahashi T., Arakawa K., Kamiya T., Nakano T.
  • Organizer: IEEE NSS/MIC/RTSD
  • Place of Presentation: 韓国
• [Presentation] An evaluation of three-dimensional imaging by use of Si/CdTe Compton cameras
  • Author(s): Yamaguchi M., Nagao Y., Kawachi N., Fujimaki S., Kamiya T., Odaka H., Kokubun M., Takeda S., Watanabe S., Takahashi T., Shimada H., Torikai K., Arakawa K., Nakano T.
  • Organizer: IEEE NSS/MIC/RTSD
  • Place of Presentation: 韓国
• [Presentation] Carbon beam microsurgery and medical compton camera for next generation microsurgery system
  • Author(s): Torikai K., Suzuki Y., Arakawa K., Noda S., Sakai M., Tashiro M., Shimada H., Yoshida Y., Kubota Y., Matsumura A., Saito A., Kanai T., Yamada S., Yamaguchi M., Nagao Y., Kawachi N., Kamiya T., Takahashi T., Takeda S., Watanabe S. and Nakano T.
  • Organizer: AMDE2013
  • Place of Presentation: 群馬大学
• [Presentation] Carbon beam microsurgery and medical compton camera for next generation brain surgery
  • Author(s): Torikai K., Suzuki Y., Arakawa K., Noda S., Sakai M., Tashiro M., Shimada H., Yoshida Y., Kubota Y., Matsumura A., Saito A., Kanai T., Yamada S., Yamaguchi M., Nagao Y., Kawachi N., Kamiya T., Takahashi T., Takeda S., Watanabe S. and Nakano T.
  • Organizer: Brain and Health Informatics 2013
  • Place of Presentation: 前橋市
• [Presentation] 医学・生物学用マルチヘッドSi/CdTe半導体コンプトンカメラのための横断断層撮像画質のシミュレーションによる評価
  • Author(s): 山口 充孝, 酒井 真理, 長尾 悠人, 河地 有木, 藤巻 秀, 荒川 和夫, 神谷 富裕, 小高 裕和, 国分 紀秀, 武田 伸一郎, 渡辺 伸, 高橋 忠幸, 鳥飼 幸太, 中野 隆史
  • Organizer: 第61回応用物理学会春季学術講演会
  • Place of Presentation: 青山学院大学
• [Presentation] 医学用Si/CdTe半導体コンプトンカメラの体幹部における散乱が画質に与える影響
  • Author(s): 酒井真理，菊地美貴子，鳥飼幸太，荒川和夫，山口充孝，長尾悠人，河地有木，藤巻秀, 神谷富裕，小高裕和，国分紀秀，武田伸一郎，渡辺伸，高橋忠幸，中野隆史
  • Organizer: 第53回日本生体医工学会大会
  • Place of Presentation: 仙台国際センター