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The design strategy for tumor diagnostic agents utilizing the functional biomolecule expression system based on gene expression analysis of tumor cells

Research Project

Project/Area Number 24659558
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionKanazawa University

Principal Investigator

KAWAI Keiichi  金沢大学, 保健学系, 教授 (30204663)

Co-Investigator(Renkei-kenkyūsha) TAMAI Ikumi  金沢大学, 薬学系, 教授 (20155237)
OKAZAWA Hidehiko  福井大学, 高エネルギー医学研究センター, 教授 (50360813)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsヒト培養細胞 / 遺伝子発現解析 / 機能性分子発現系 / ポストFDG / 腫瘍診断薬 / アミノ酸トランスポータ / 薬物トランスポータ / 設計戦略 / ポストFDG製剤 / 細胞集積機序 / 腫瘍細胞集積機序
Outline of Final Research Achievements

In this study, while searching this research for the functional biomolecule used by the database for the gene expression level in the human cultured cells for evaluation of imaging probes, as well as human tumor culturing cells in a stable functional molecule was confirmed with high expression by using the expression system for the screening of molecular probes, the labeled amino acid derivatives are especially taken up also in a post-FDG candidate probe, and the accumulation mechanism of the labeled amino acids which shows high affinity to the amino acid transporters to which high revelation is specifically accepted by a tumor was examined in detail, and the validity of the design strategy was evaluated from correlation with amino acid transporter gene expression and tumor accumulation of the probes.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (61 results)

All 2015 2014 2013 2012 Other

All Journal Article (28 results) (of which Peer Reviewed: 28 results,  Acknowledgement Compliant: 4 results,  Open Access: 4 results) Presentation (26 results) (of which Invited: 1 results) Book (1 results) Remarks (6 results)

  • [Journal Article] In vivo radioactive metabolite analysis for individualized medicine: a basic study of a new method of CYP activity assay using (123)I-IMP.2015

    • Author(s)
      Nishi K, Mizutani A, Shikano N, Fujita K, Kobayashi M, Ono M, Nishii R, Sasaki Y, Kinuya S, Kawai K.
    • Journal Title

      Nucl Med Biol

      Volume: 2 Issue: 2 Pages: 171-176

    • DOI

      10.1016/j.nucmedbio.2014.08.015

    • NAID

      120006986250

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Novel Injection Strategy of Flurbiprofen-axetil by Inhibiting Protein Binding with 6-Methoxy-2-naphthylacetic Acid.2015

    • Author(s)
      Ogata K., Takamura N., Tokunaga J., Ikeda T., Setoguchi N., Tanda K,., Yamasaki T., Nishio T., Kawai K.
    • Journal Title

      Eur. J. Drug Metab. Pharmacok.

      Volume: 40

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A strategy for improving FDG accumulation for early detection of metastasis from primary pancreatic cancer: Stimulation of the Warburg effect in AsPC-1 cells.2015

    • Author(s)
      Ogura M, Shikano N, Nakajima S, Sagara J, Yamaguchi N, Kusanagi K, Okui Y, Mizutani A, Kobayashi M, Kawai K.
    • Journal Title

      Nuclear Medicine and Biology

      Volume: 42 Issue: 5 Pages: 475-481

    • DOI

      10.1016/j.nucmedbio.2014.12.017

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Development of radioiodine-labeled 4-hydroxyphenylcysteamine for specific diagnosis of malignant melanoma.2015

    • Author(s)
      Kobayashi M, Nishii R, Shikano N, Flores LG 2nd, Mizutani A, Ogai K, Sugama J, Nagamachi S, Kawai K.
    • Journal Title

      Nucl Med Biol

      Volume: 6 Issue: 6 Pages: 536-540

    • DOI

      10.1016/j.nucmedbio.2015.02.004

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transport mechanisms of hepatic uptake and bile excretion in clinical hepatobiliary scintigraphy with 99mTc-N-pyridoxyl-5-methyltryptophan.2014

    • Author(s)
      Kobayashi M, Nakanishi T, Nishi K, Higaki Y, Okudaira H, Ono M, Tsujiuchi T, Mizutani A, Nishii R, Tamai I, Arano Y, Kawai K.
    • Journal Title

      Nucl Med Biol

      Volume: 4 Issue: 4 Pages: 338-342

    • DOI

      10.1016/j.nucmedbio.2014.01.004

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differences in Transport Mechanisms of Trans-1-amino-3-[18F]fluorocyclobutanecarboxylic Acid in Inflammatory, Prostate Cancer, and Glioma Cells: Comparison with L-[Methyl-11C]methionine and 2-Deoxy-2-[18F]fluoro-D-glucose.2014

    • Author(s)
      Oka S., Okudaira H., Ono M., Schuster D.M., Goodman M.M., Kawai K., Shirakami Y.
    • Journal Title

      Mol. Imaging Biol.

      Volume: 16(3) Issue: 3 Pages: 322-329

    • DOI

      10.1007/s11307-013-0693-0

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Performance evaluation of the eXplore speCZT preclinical imaging system.2014

    • Author(s)
      Matsunari I, Miyazaki Y, Kobayashi M, Nishi K, Mizutani A, Kawai K, Hayashi A, Komatsu R, Yonezawa R, Kinuya S.
    • Journal Title

      Annuls of Nuclear medicine

      Volume: 28 Issue: 5 Pages: 484-497

    • DOI

      10.1007/s12149-014-0828-7

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Application of a medium-energy collimator for I-131 imaging after ablation treatment of differentiated thyroid cancer.2014

    • Author(s)
      Kobayashi M, Wakabayashi H, Kayano D, Konishi T, Kojima H, Okuda K, Yoneyama H, Tsushima H, Onoguchi M, Kawai K, Kinuya S.
    • Journal Title

      Annuls of Nuclear medicine

      Volume: 28 Issue: 6 Pages: 551-558

    • DOI

      10.1007/s12149-014-0845-6

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Accumulation of trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid in prostate cancer due to androgen-induced expression of amino-acid transporters.2014

    • Author(s)
      Okudaira H, Oka S, Ono M, Nakanishi T, Shuster DM, Kobayashi M, Goodman MM, Tamai I, Kawai K, Shirakami Y.
    • Journal Title

      Molecular Imaging and Biology

      Volume: 16 Issue: 6 Pages: 756-764

    • DOI

      10.1007/s11307-014-0756-x

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Increased metabolite levels of glycolysis and pentose phosphate pathway in rabbit atherosclerotic arteries and hypoxic macrophage2014

    • Author(s)
      Atsushi Yamashita, Yan Zhao, Yunosuke Matsuura, Kazuaki Yamasaki, Sayaka Moriguchi-Goto, Chihiro Sugita, Takashi Iwakiri, Nozomi Okuyama, Chihiro Koshimoto, Keiichi Kawai, Nagara Tamaki, Songji Zhao, Yuji Kuge, Yujiro Asada
    • Journal Title

      PLos One

      Volume: 9 Issue: 1 Pages: e86426-e86426

    • DOI

      10.1371/journal.pone.0086426

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influences of Artificial Heart-lung Machine Operation on the Binding Sites of Albumin: Possibility of an Effective Administration Plan.2014

    • Author(s)
      Totoribe K., Takamura N., Ogata K., Tokunaga J., Kawai K., Nakamura K., Ieiri I., Higuchi S.
    • Journal Title

      Int. J. Artif. Organs

      Volume: 2(37) Issue: 2 Pages: 99-108

    • DOI

      10.5301/ijao.5000299

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Monitoring of Gefitinib Sensitivity with Radioiodinated PHY based on EGFR Expression.2014

    • Author(s)
      Yoshimoto M., Hirata M., Kanai Y., Naka S., Nishii R., Kagawa S., Kawai K., Ohmomo Y.
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 37(3) Pages: 355-360

    • NAID

      130003390939

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differences in Transport Mechanisms of Trans-1-amino-3-[18F]fluorocyclobutanecarboxylic acid in Inflammatory, Prostate Cancer, and Glioma Cells: Comparison with L-[Methyl-11C]methionine and [18F]Fluoro-D-deoxy glucose.2014

    • Author(s)
      Oka S., Okudaira H., Ono M., Schuster D.M., Goodman M.M., Kawai K., Shirakami Y.
    • Journal Title

      Mol. Imaging Biol.

      Volume: 16

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Appropriate collimators in a small animal SPECT scanner with CZT detector.2013

    • Author(s)
      Higaki Y, Kobayashi M, Uehara K, Hanaoka H, Arano Y, Kawai K.
    • Journal Title

      Annals of Nuclear Medicine

      Volume: 27 Issue: 3 Pages: 271-278

    • DOI

      10.1007/s12149-012-0681-5

    • NAID

      10031168094

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Predominant contribution of L-type amino acid transporter to 4-borono-2-18F-fluoro-phenylalanine uptake in human glioblastoma cells2013

    • Author(s)
      Yoshimoto M, Kurihara H, Honda N, Kawai K, Ohe K, Fujii H, Itami J, Arai Y.
    • Journal Title

      Nuclear Medicine and Biology

      Volume: 40 Issue: 5 Pages: 625-629

    • DOI

      10.1016/j.nucmedbio.2013.02.010

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Kinetic analyses of trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid transport in Xenopus laevis oocytes expressing human ASCT2 and SNAT2.2013

    • Author(s)
      Okudaira H, Nakanishi T, Oka S, Kobayashi M, Tamagami H, Schuster DM, Goodman MM, Shirakami Y, Tamai I, Kawai K.
    • Journal Title

      Nuclear Medicine and Biology

      Volume: 40 Issue: 5 Pages: 670-675

    • DOI

      10.1016/j.nucmedbio.2013.03.009

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Usefulness of 18F-FDG PET/MRI Fusion Image in Diagnosing Pancreatic Tumor: Comparison with 18F-FDG PET/CT.2013

    • Author(s)
      Nagamachi S., Nishii R., Wakamatsu H., Mizutani Y., Kiyohara S., Fujita S., Futami S., Sakae T., Furukoji E., Tamura S., Arita H., Chijiiwa K., Kawai K.
    • Journal Title

      Ann. Nucl. Med.

      Volume: 27(6) Issue: 6 Pages: 554-563

    • DOI

      10.1007/s12149-013-0719-3

    • NAID

      10031189359

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Binding of Sulforhodamine B to Human Serum Albumin: A Spectroscopic Study.2013

    • Author(s)
      Kitamura M., Murakami K., Yamada K., Kawai K., Kunishima M.
    • Journal Title

      Dyes and Pigments.

      Volume: 99(3) Pages: 588-593

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Diagnostic usefulness of an amino acid tracer, α-[N-methyl- ^11C]-methylaminoisobutyric acid ( ^<11>C-MeAIB), in the PET diagnosis of chest malignancies2013

    • Author(s)
      Nishii R, Higashi T, Kagawa S, Kishibe Y, Takahashi M, Yamauchi H, Motoyama H, Kawakami K, Nakaoku T, Nohara J, Okamura M, Watanabe T, Nakatani K, Nagamachi S, Tamura S, Kawai K, Kobayashi M
    • Journal Title

      Ann Nucl Med

      Volume: 27(9) Issue: 9 Pages: 808-21

    • DOI

      10.1007/s12149-013-0750-4

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Arterial 18F-Fluorodeoxyglucose Uptake Reflects Balloon Catheter-Induced Thrombus Formation and Tissue Factor Expression via Nuclear Factor-κB in Rabbit Atherosclerotic Lesions.2013

    • Author(s)
      Yamashita A., Zhao Y., Zhao S., Matsuura Y., Sugita C., Iwakiri T., Okuyama N., Ohe K., Koshimoto C., Kawai K., Tamaki N., Kuge Y., Asada Y.
    • Journal Title

      Circ. J.

      Volume: 77(10) Pages: 2626-2635

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparative Evaluation of Transport Mechanisms of Trans-1-amino-3-[18F]fluorocyclobutane- carboxylic Acid and L-[Methyl-11C]methionine in Human Glioma Cell Lines.2013

    • Author(s)
      Ono M., Oka S., Okudaira H., Schuster D.M., Goodman M.M., Kawai K., Shirakami Y.
    • Journal Title

      Brain Res.

      Volume: 1535 Pages: 24-37

    • DOI

      10.1016/j.brainres.2013.08.037

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prototype Imaging Protocols for Monitoring the Efficacy of Iodine-131 Ablation in Differentiated Thyroid Cancer.2013

    • Author(s)
      Kobayashi M., Wakabayashi H., Kojima H., Konishi T., Okuda K., Yoneyama H., Kayano D., Tobisaka M., Tsushima H., Onoguchi M., Kawai K., Kinuya S.
    • Journal Title

      Hell. J. Nucl. Med.

      Volume: 16(3) Pages: 175-180

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A diclofenac suppository-nabumetone combination therapy for arthritic pain relief and a monitoring method for the diclofenac binding capacity of HSA site II in rheumatoid arthritis2013

    • Author(s)
      Nao Setoguchi, Norito Takamura, Ken-ichi Fujita, Kenji Ogata, Jin Tokunaga, Toyotaka Nishio, Etsuo Chosa, Kazuhiko Arimori, Keiichi Kawai, Ryuichi Yamamoto
    • Journal Title

      Biopharmaceutics & Drug Disposition

      Volume: 34 (2) Issue: 2 Pages: 125-136

    • DOI

      10.1002/bdd.1829

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pharmacokinetic Alteration of 99mTc-MAG3 using Serum Protein Binding Displacement Method.2013

    • Author(s)
      K Nishi, M Kobayashi, R Nishii, N Shikano, N Takamura, N Kuga, K Yamasaki, S Nagamachi, S Tamura, M Otagiri, K Kawai.
    • Journal Title

      Nucl Med Biol

      Volume: 40 Issue: 3 Pages: 366-370

    • DOI

      10.1016/j.nucmedbio.2012.12.002

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] N-Isopropyl-p-iodoamphetamine Hydrochloride (IMP) is Predominantly Metabolized by CYP2C19.2012

    • Author(s)
      Fujita K., Sugiyama M., Akiyama Y., Hioki K., Kunishima M., Nishi K., Kobayashi M., Kawai K., Sasaki Y.
    • Journal Title

      Drug Metab. Dispos.

      Volume: 40 Issue: 5 Pages: 843-846

    • DOI

      10.1124/dmd.111.043893

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions.2012

    • Author(s)
      Arakawa H, Nakanishi T, Yanagihara C, Nishimoto T, Wakayama T, Mizokami A, Namiki M, Kawai K, Tamai I.
    • Journal Title

      Biochem Pharmacol

      Volume: 84 Issue: 8 Pages: 1070-1077

    • DOI

      10.1016/j.bcp.2012.07.026

    • NAID

      120004997008

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transport mechanism of (11)C-labeled L- and D-methionine in human-derived tumor cells.2012

    • Author(s)
      M Kobayashi, F Hashimoto, K Ohe, T Nadamura, K Nishi, N Shikano, R Nishii, T Higashi, H Okazawa, K Kawai.
    • Journal Title

      Nucl Med Biol

      Volume: 39 Issue: 8 Pages: 1213-1218

    • DOI

      10.1016/j.nucmedbio.2012.06.006

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Down-regulation of Calcium/calmodulin-dependent Protein Kinase Kinase 2 by Androgen Deprivation Induces Castration-resistant Prostate Cancer.2012

    • Author(s)
      Shima T., Mizokami A., Miyagi T., Kawai K., Izumi K., Kumaki M., Ofude M., Zhang J., Keller E.T., Namiki M.
    • Journal Title

      Prostate

      Volume: 72 Issue: 16 Pages: 1789-1801

    • DOI

      10.1002/pros.22533

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Transport Mechanism of the Amino Acid Positron Emission Tomography Tracer [18F]Fluciclovine and its Application to Glioma Diagnosis.2014

    • Author(s)
      Ono M., Doi Y., Oka S., Okudaira H., Schuster D.M., Goodman M.M., Matsumoto H. Kawai K., Shirakami Y
    • Organizer
      19th North American ISSX Meeting / 29th JSSX Meeting
    • Place of Presentation
      Hilton San Francisco, San Francisco, California, U.S.A
    • Year and Date
      2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Pharmacokinetics and Anti-tumor Activity of AY002 with High Affinity to EGFR-TK.2014

    • Author(s)
      Yoshimoto M., Kimura S., Hirata M., Ohmomo Y., Kawai K., Fujii H.
    • Organizer
      The Society of Nuclear Medicine 61th Annual Meeting
    • Place of Presentation
      Renaissance St. Louis Grand Hotel, St. Louis, Missouri, U.S.A.
    • Year and Date
      2014-06-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Radiosynthesis of [18F]FPYBF-2, a Novel PET Imaging Probe for β-Amyloid Plaques in Brain.2014

    • Author(s)
      Kagawa S., Nishii R., Higashi T., Yamauchi H., Kawai K., Watanabe H., Kimura H., Ono M., Saji H.
    • Organizer
      The Society of Nuclear Medicine 61th Annual Meeting
    • Place of Presentation
      Renaissance St. Louis Grand Hotel, St. Louis, Missouri, U.S.A.
    • Year and Date
      2014-06-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Introduction of Radiobromine Labeled Decalinvesamicol Analogue as a New and Promising PET Vesicular Acetylcholine Transporter (VAChT) Imaging Probe.2014

    • Author(s)
      Azim M.A., Kosaka T., Uno I., Miwa D., Kitamura Y., Ogawa K., Kawai K., Kiyono Y., Shiba K.
    • Organizer
      The Society of Nuclear Medicine 61th Annual Meeting
    • Place of Presentation
      Renaissance St. Louis Grand Hotel, St. Louis, Missouri, U.S.A.
    • Year and Date
      2014-06-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Increased Metabolite Levels of Glycolysis and Pentose Phosphate Pathway in Rabbit Atherosclerotic Arteries and Hypoxic Macrophage.2014

    • Author(s)
      Yamashita A., Zhao Y., Matsuura Y., Yamasaki K., Moriguchi-Goto S., Iwakiri T., Okuyama N., Koshimoto C., Kawai K., Tamaki N., Zhao S., Kuge Y., Asada Y.
    • Organizer
      Arteriosclerosis, Thrombosis and Vascular Biology
    • Place of Presentation
      Sheraton Centre Toronto Hotel, Toronto, Canada
    • Year and Date
      2014-05-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 18F-FDG Uptake Reflects Thrombus Formation and Tissue Factor Expression via Nuclear Factor-κB in Rabbit Atherosclerotic Lesions.2012

    • Author(s)
      Yamashita A., Zhao Y., Zhao S., Matsuura Y., Sugita C., Iwakiri T., Ohe K., Koshimoto C., Kawai K., Tamaki N., Kuge Y., Asada Y.
    • Organizer
      American Heart Association Scientific Sessions 2012
    • Place of Presentation
      Los Angeles Convention Center (USA)
    • Related Report
      2012 Research-status Report
  • [Presentation] Synthesis and Evaluation of Iodinated Cyclopropanecarboxylic Acid {3-[6-(Phenylamino)- pyrimidin-4-ylamino]-phenyl}-amides as EGFR-TK Imaging Agents.

    • Author(s)
      Yoshimoto M., Kimura S., Yamada K., Hirata M., Ohmomo Y., Kunishima M., Kawai K., Fujii H.
    • Organizer
      20th International Symposium on Radiopharmaceutical Sciences
    • Place of Presentation
      Jeju International Convention Center (Korea)
    • Related Report
      2013 Research-status Report
  • [Presentation] Radiosynthesis of [18F]Fluoroacetate by a One-pot Distillation Procedure: A Novel Approach of the Solid-phase Synthesis.

    • Author(s)
      Kagawa S., Nishii R., Higashi T., Yamauchi H., Takemoto K., Hatano E., Tachibana A., Takahashi K., Mizuma H., Onoe H., Nagamachi S., Kawai K., Tamura S.
    • Organizer
      20th International Symposium on Radiopharmaceutical Sciences
    • Place of Presentation
      Jeju International Convention Center (Korea)
    • Related Report
      2013 Research-status Report
  • [Presentation] Development of Novel EGFR-TK Imaging Agents based on Anilinopyrimidine Structure.

    • Author(s)
      Yoshimoto M., Kimura S., Hirata M., Ohmomo Y., Kawai K., Fujii H.
    • Organizer
      The Society of Nuclear Medicine 60th Annual Meeting
    • Place of Presentation
      Vancouver Convention Centre (Canada)
    • Related Report
      2013 Research-status Report
  • [Presentation] Novel Approach for Solid-phase Radiosynthesis of 18F-Fluoroacetate: Comparison between One-pot and Two-pot Distillation Procedure.

    • Author(s)
      Kagawa S., Nishii R., Higashi T., Yamauchi H., Takemoto K., Tachibana A., Takahashi K., Mizuma H., Onoe H., Kawai K.
    • Organizer
      The Society of Nuclear Medicine 60th Annual Meeting
    • Place of Presentation
      Vancouver Convention Centre (Canada)
    • Related Report
      2013 Research-status Report
  • [Presentation] The Development of Potential Vesicular Acetylcholine Transporter (VAChT) PET Imaging Probes.

    • Author(s)
      Kosaka T., Miwa D., Uno I., Kitamura Y., Azim M.A., Ogawa K., Kinuya S., Kawai K., Shiba K.
    • Organizer
      The Society of Nuclear Medicine 60th Annual Meeting
    • Place of Presentation
      Vancouver Convention Centre (Canada)
    • Related Report
      2013 Research-status Report
  • [Presentation] In vivo Evaluation of Radioiodinated o-Iodo-trans-decalinvesamicol (OIDV) as a Vesicular Acetylcholine Transporter (VAChT ) Imaging Agent.

    • Author(s)
      Uno I., Kosaka T., Kitamura Y., Miwa D., Azim M.A., Ogawa K., Kawai K., Taki J., Kinuya S., Shiba K.
    • Organizer
      The Society of Nuclear Medicine 60th Annual Meeting
    • Place of Presentation
      Vancouver Convention Centre (Canada)
    • Related Report
      2013 Research-status Report
  • [Presentation] Comparison between a High- and Medium-energy Collimator for Na131I Imaging of Differentiated Thyroid Cancer.

    • Author(s)
      Kobayashi M., Wakabayashi H., Kayano D., Nishi K., Onoguchi M., Kawai K., Kinuya S.
    • Organizer
      The Society of Nuclear Medicine 60th Annual Meeting
    • Place of Presentation
      Vancouver Convention Centre (Canada)
    • Related Report
      2013 Research-status Report
  • [Presentation] Development of Ultra-high-resolution Pinhole Collimator for Small-animal SPECT with CZT Detector.

    • Author(s)
      Nishi K., Kobayashi M., Matsunari I., Miyazaki Y., Shiba K., Kawai K., Kinuya S.
    • Organizer
      The Society of Nuclear Medicine 60th Annual Meeting
    • Place of Presentation
      Vancouver Convention Centre (Canada)
    • Related Report
      2013 Research-status Report
  • [Presentation] Transport Mechanism of Trans-1-amino-3-18F-fluorocyclobutanecarboxylic Acid (18F-FACBC) PET Radiotracer in Human Prostate Cancer.

    • Author(s)
      Okudaira H., Oka S., Nakanishi T., Kobayashi M., Tamagami H., Schuster D.M., Goodman M.M., Shirakami Y., Tamai I., Kawai K.
    • Organizer
      The Society of Nuclear Medicine 60th Annual Meeting
    • Place of Presentation
      Vancouver Convention Centre (Canada)
    • Related Report
      2013 Research-status Report
  • [Presentation] System A Amino Acid Transport C-11 MeAIB PET/CT Imaging for Diagnosing Prostate Cancer.

    • Author(s)
      Nishii R., Higashi T., Kagawa S., Kishibe Y., Takahashi M., Kobayashi M., Nagamachi S., Mizutani Y., Kawai K., Tamura S.
    • Organizer
      World Molecular Imaging Congress 2013
    • Place of Presentation
      Savannah International Trade & Convention Centre (USA)
    • Related Report
      2013 Research-status Report
  • [Presentation] Correlations between FDG Uptake Indices and the Expression of Various Type Oncogenes (KRAS, BRAF, HIF-1, EGFR, CDH13, p53, Ki67, Glut 1 and Glut 3) in Biliary Cancer: A Comparison Study to MRI Diffusion Weighted Image Parameters.

    • Author(s)
      Nagamachi S., Nishii R., Mizutani Y., Kiyohara S., Shibata N., Kondo K., Kai M., Tamura S., Chijiiwa K., Kawai K., Fujita S., Wakamatsu H., Futami S.
    • Organizer
      Radiological Society of North America 2013, 99th Scientific Assembly and Annual Meeting
    • Place of Presentation
      McCormick Place, Chicago (USA)
    • Related Report
      2013 Research-status Report
  • [Presentation] The Correlation between SUVmax of 18F-FDG PET/CT and Apparent Diffusion Coefficients (ADC) in Pancreas Cancer and Biliary Cancer?

    • Author(s)
      Nagamachi S., Nishii R., Mizutani Y., Kiyohara S., Furukoji E., Sakae T., Tamura S., Wakamatsu H., Fujita S., Futami S., Kawai K.
    • Organizer
      Radiological Society of North America 2013, 99th Scientific Assembly and Annual Meeting
    • Place of Presentation
      McCormick Place, Chicago (USA)
    • Related Report
      2013 Research-status Report
  • [Presentation] Evaluation of Radioiodinated PYK for Monitoring Active Mutation of EGFR-TK.

    • Author(s)
      Yoshimoto M., Hirata M., Magata Y., Nishii R., Kawai K., Ohmomo Y.
    • Organizer
      The Society of Nuclear Medicine 59th Annual Meeting
    • Place of Presentation
      Miami Beach Convention Center (USA)
    • Related Report
      2012 Research-status Report
  • [Presentation] Accumulation Mechanism of 11C Labeled D-Methionine in Human-Derived Tumor Cells: Comparison with Gene Expression of Amino Acid Transporter System.

    • Author(s)
      Kobayashi M., Hashimoto F., Ohe K., Nadamura T., Nishi K., Okudaira H., Higashi T., Shikano N., Nishii R., Kawai K.
    • Organizer
      The Society of Nuclear Medicine 59th Annual Meeting
    • Place of Presentation
      Miami Beach Convention Center (USA)
    • Related Report
      2012 Research-status Report
  • [Presentation] Assessment of Efficacy of [11C]MeAIB PET/CT as a Biomarker of the System A Amino Acid Transport: Comparison with [18F]FDG and MRI in the Patients with Prostate Cancer.

    • Author(s)
      Higashi T., Nishii R., Kagawa S., Takahashi M., Kishibe Y., Yamauchi H., Ishitoya S., Oonishi H., Kawai K., Kobayashi M.
    • Organizer
      The Society of Nuclear Medicine 59th Annual Meeting
    • Place of Presentation
      Miami Beach Convention Center (USA)
    • Related Report
      2012 Research-status Report
  • [Presentation] Imaging Acquisition and Processing Protocols during Iodine-131 Therapy for Differentiated Thyroid Cancer.

    • Author(s)
      Kobayashi M., Wakabayashi H., Kojima H., Konishi T., Okuda K., Kayano D., Tobisaka M., Onoguchi M., Kawai K., Kinuya S.
    • Organizer
      The Society of Nuclear Medicine 59th Annual Meeting
    • Place of Presentation
      Miami Beach Convention Center (USA)
    • Related Report
      2012 Research-status Report
  • [Presentation] Usefulness of System A Amino Acid Transport PET Imaging with C-11-MeAIB in Diagnosing Brain Tumors: A Comparison Study with C-11-Methionine PET Imaging.

    • Author(s)
      Nishii R., Higashi T., Kagawa S., Kishibe Y., Takahashi M., Kobayashi M., Ohe K., Kawai K., Nagamachi S., Tamura S.
    • Organizer
      The Society of Nuclear Medicine 59th Annual Meeting
    • Place of Presentation
      Miami Beach Convention Center (USA)
    • Related Report
      2012 Research-status Report
  • [Presentation] Mechanism of Hepatic Uptake Transport and Bile Excretion in Hepatobiliary Scintigraphy with A 99mTc Labeled Pyridoxylaminate Group.

    • Author(s)
      Kobayashi M., Ohe K., Nadamura T., Nishi K., Higashi T., Okudaira H., Shikano N., Nishii R., Kawai K.
    • Organizer
      The Society of Nuclear Medicine 59th Annual Meeting
    • Place of Presentation
      Miami Beach Convention Center (USA)
    • Related Report
      2012 Research-status Report
  • [Presentation] The Usefulness of 18F-PET/MRI Fusion Image in Diagnosing Pancreatic Tumor: Comparison with 18F-FDG PET/CT.

    • Author(s)
      Nagamachi S., Nishii R., Mizutani Y., Kiyohara S., Wakamatsu H., Fujita S., Futami S., Tamura S., Kawai K.
    • Organizer
      The Society of Nuclear Medicine 59th Annual Meeting
    • Place of Presentation
      Miami Beach Convention Center (USA)
    • Related Report
      2012 Research-status Report
  • [Presentation] 薬物動態解析に特化した小動物用インビボ分子イメージング装置の開発

    • Author(s)
      川井恵一
    • Organizer
      石川県産業創出支援機構 平成24年度医療機器開発マッチングフォーラム
    • Place of Presentation
      金沢大学 (石川県)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] 「放射線関係法規概説 -医療分野も含めて-」(第5版)2013

    • Author(s)
      川井恵一
    • Total Pages
      222
    • Publisher
      通商産業研究社
    • Related Report
      2012 Research-status Report
  • [Remarks] 金沢大学医薬保健研究域保健学系 量子医療技術学講座 川井研究室

    • URL

      http://kawai.w3.kanazawa-u.ac.jp/index.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 金沢大学 研究者情報

    • URL

      http://ridb.kanazawa-u.ac.jp/public/detail.php?id=2789&page=1&search=1&keyword=%E5%B7%9D%E4%BA%95&andor=AND&tgt1=1&tgt2=&tgt3=&tgt4=

    • Related Report
      2014 Annual Research Report
  • [Remarks] 金沢大学医薬保健研究域保健学系 量子医療技術学講座 川井研究室

    • URL

      http://kawai.w3.kanazawa-u.ac.jp/index.html

    • Related Report
      2013 Research-status Report
  • [Remarks] 金沢大学 研究紹介

    • URL

      http://ridb.kanazawa-u.ac.jp/public/detail.php?id=2789&page=1&search=1&keyword=%E5%B7%9D%E4%BA%95&andor=AND&tgt1=1&tgt2=&tgt3=&tgt4=

    • Related Report
      2013 Research-status Report
  • [Remarks] 金沢大学 研究紹介データベース

    • URL

      http://ridb.kanazawa-u.ac.jp/public/detail.php?id=2789&page=1&search=1&keyword=%E5%B7%9D%E4%BA%95%E3%80%80%E6%83%A0%E4%B8%80&andor=AND&tgt1=1&tgt2=&tgt3=&tgt4=

    • Related Report
      2012 Research-status Report
  • [Remarks] 金沢大学医薬保健研究域保健学系 量子医療技術学講座 川井研究室

    • URL

      http://kawai.w3.kanazawa-u.ac.jp/index.html

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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