The design strategy for tumor diagnostic agents utilizing the functional biomolecule expression system based on gene expression analysis of tumor cells

• Project/Area Number: 24659558
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kanazawa University
• Principal Investigator: KAWAI Keiichi 金沢大学, 保健学系, 教授 (30204663)
• Co-Investigator(Renkei-kenkyūsha): TAMAI Ikumi 金沢大学, 薬学系, 教授 (20155237) ; OKAZAWA Hidehiko 福井大学, 高エネルギー医学研究センター, 教授 (50360813)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: ヒト培養細胞 / 遺伝子発現解析 / 機能性分子発現系 / ポストＦＤＧ / 腫瘍診断薬 / アミノ酸トランスポータ / 薬物トランスポータ / 設計戦略 / ポストＦＤＧ製剤 / 細胞集積機序 / 腫瘍細胞集積機序

Outline of Final Research Achievements

In this study, while searching this research for the functional biomolecule used by the database for the gene expression level in the human cultured cells for evaluation of imaging probes, as well as human tumor culturing cells in a stable functional molecule was confirmed with high expression by using the expression system for the screening of molecular probes, the labeled amino acid derivatives are especially taken up also in a post-FDG candidate probe, and the accumulation mechanism of the labeled amino acids which shows high affinity to the amino acid transporters to which high revelation is specifically accepted by a tumor was examined in detail, and the validity of the design strategy was evaluated from correlation with amino acid transporter gene expression and tumor accumulation of the probes.

Research Products

• [Journal Article] In vivo radioactive metabolite analysis for individualized medicine: a basic study of a new method of CYP activity assay using (123)I-IMP. (2015)
  • Author(s): Nishi K, Mizutani A, Shikano N, Fujita K, Kobayashi M, Ono M, Nishii R, Sasaki Y, Kinuya S, Kawai K.
  • Journal Title: Nucl Med Biol Volume: 2 Issue: 2 Pages: 171-176
  • DOI: 10.1016/j.nucmedbio.2014.08.015
  • NAID: 120006986250
  • Peer Reviewed / Open Access
• [Journal Article] A Novel Injection Strategy of Flurbiprofen-axetil by Inhibiting Protein Binding with 6-Methoxy-2-naphthylacetic Acid. (2015)
  • Author(s): Ogata K., Takamura N., Tokunaga J., Ikeda T., Setoguchi N., Tanda K,., Yamasaki T., Nishio T., Kawai K.
  • Journal Title: Eur. J. Drug Metab. Pharmacok. Volume: 40
  • Peer Reviewed
• [Journal Article] A strategy for improving FDG accumulation for early detection of metastasis from primary pancreatic cancer: Stimulation of the Warburg effect in AsPC-1 cells. (2015)
  • Author(s): Ogura M, Shikano N, Nakajima S, Sagara J, Yamaguchi N, Kusanagi K, Okui Y, Mizutani A, Kobayashi M, Kawai K.
  • Journal Title: Nuclear Medicine and Biology Volume: 42 Issue: 5 Pages: 475-481
  • DOI: 10.1016/j.nucmedbio.2014.12.017
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Development of radioiodine-labeled 4-hydroxyphenylcysteamine for specific diagnosis of malignant melanoma. (2015)
  • Author(s): Kobayashi M, Nishii R, Shikano N, Flores LG 2nd, Mizutani A, Ogai K, Sugama J, Nagamachi S, Kawai K.
  • Journal Title: Nucl Med Biol Volume: 6 Issue: 6 Pages: 536-540
  • DOI: 10.1016/j.nucmedbio.2015.02.004
  • Peer Reviewed / Open Access
• [Journal Article] Transport mechanisms of hepatic uptake and bile excretion in clinical hepatobiliary scintigraphy with 99mTc-N-pyridoxyl-5-methyltryptophan. (2014)
  • Author(s): Kobayashi M, Nakanishi T, Nishi K, Higaki Y, Okudaira H, Ono M, Tsujiuchi T, Mizutani A, Nishii R, Tamai I, Arano Y, Kawai K.
  • Journal Title: Nucl Med Biol Volume: 4 Issue: 4 Pages: 338-342
  • DOI: 10.1016/j.nucmedbio.2014.01.004
  • Peer Reviewed
• [Journal Article] Differences in Transport Mechanisms of Trans-1-amino-3-[18F]fluorocyclobutanecarboxylic Acid in Inflammatory, Prostate Cancer, and Glioma Cells: Comparison with L-[Methyl-11C]methionine and 2-Deoxy-2-[18F]fluoro-D-glucose. (2014)
  • Author(s): Oka S., Okudaira H., Ono M., Schuster D.M., Goodman M.M., Kawai K., Shirakami Y.
  • Journal Title: Mol. Imaging Biol. Volume: 16(3) Issue: 3 Pages: 322-329
  • DOI: 10.1007/s11307-013-0693-0
  • Peer Reviewed
• [Journal Article] Performance evaluation of the eXplore speCZT preclinical imaging system. (2014)
  • Author(s): Matsunari I, Miyazaki Y, Kobayashi M, Nishi K, Mizutani A, Kawai K, Hayashi A, Komatsu R, Yonezawa R, Kinuya S.
  • Journal Title: Annuls of Nuclear medicine Volume: 28 Issue: 5 Pages: 484-497
  • DOI: 10.1007/s12149-014-0828-7
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Application of a medium-energy collimator for I-131 imaging after ablation treatment of differentiated thyroid cancer. (2014)
  • Author(s): Kobayashi M, Wakabayashi H, Kayano D, Konishi T, Kojima H, Okuda K, Yoneyama H, Tsushima H, Onoguchi M, Kawai K, Kinuya S.
  • Journal Title: Annuls of Nuclear medicine Volume: 28 Issue: 6 Pages: 551-558
  • DOI: 10.1007/s12149-014-0845-6
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Accumulation of trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid in prostate cancer due to androgen-induced expression of amino-acid transporters. (2014)
  • Author(s): Okudaira H, Oka S, Ono M, Nakanishi T, Shuster DM, Kobayashi M, Goodman MM, Tamai I, Kawai K, Shirakami Y.
  • Journal Title: Molecular Imaging and Biology Volume: 16 Issue: 6 Pages: 756-764
  • DOI: 10.1007/s11307-014-0756-x
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Increased metabolite levels of glycolysis and pentose phosphate pathway in rabbit atherosclerotic arteries and hypoxic macrophage (2014)
  • Author(s): Atsushi Yamashita, Yan Zhao, Yunosuke Matsuura, Kazuaki Yamasaki, Sayaka Moriguchi-Goto, Chihiro Sugita, Takashi Iwakiri, Nozomi Okuyama, Chihiro Koshimoto, Keiichi Kawai, Nagara Tamaki, Songji Zhao, Yuji Kuge, Yujiro Asada
  • Journal Title: PLos One Volume: 9 Issue: 1 Pages: e86426-e86426
  • DOI: 10.1371/journal.pone.0086426
  • Peer Reviewed / Open Access
• [Journal Article] Influences of Artificial Heart-lung Machine Operation on the Binding Sites of Albumin: Possibility of an Effective Administration Plan. (2014)
  • Author(s): Totoribe K., Takamura N., Ogata K., Tokunaga J., Kawai K., Nakamura K., Ieiri I., Higuchi S.
  • Journal Title: Int. J. Artif. Organs Volume: 2(37) Issue: 2 Pages: 99-108
  • DOI: 10.5301/ijao.5000299
  • Peer Reviewed
• [Journal Article] Monitoring of Gefitinib Sensitivity with Radioiodinated PHY based on EGFR Expression. (2014)
  • Author(s): Yoshimoto M., Hirata M., Kanai Y., Naka S., Nishii R., Kagawa S., Kawai K., Ohmomo Y.
  • Journal Title: Biol. Pharm. Bull. Volume: 37(3) Pages: 355-360
  • NAID: 130003390939
  • Peer Reviewed
• [Journal Article] Differences in Transport Mechanisms of Trans-1-amino-3-[18F]fluorocyclobutanecarboxylic acid in Inflammatory, Prostate Cancer, and Glioma Cells: Comparison with L-[Methyl-11C]methionine and [18F]Fluoro-D-deoxy glucose. (2014)
  • Author(s): Oka S., Okudaira H., Ono M., Schuster D.M., Goodman M.M., Kawai K., Shirakami Y.
  • Journal Title: Mol. Imaging Biol. Volume: 16
  • Peer Reviewed
• [Journal Article] Appropriate collimators in a small animal SPECT scanner with CZT detector. (2013)
  • Author(s): Higaki Y, Kobayashi M, Uehara K, Hanaoka H, Arano Y, Kawai K.
  • Journal Title: Annals of Nuclear Medicine Volume: 27 Issue: 3 Pages: 271-278
  • DOI: 10.1007/s12149-012-0681-5
  • NAID: 10031168094
  • Peer Reviewed
• [Journal Article] Predominant contribution of L-type amino acid transporter to 4-borono-2-18F-fluoro-phenylalanine uptake in human glioblastoma cells (2013)
  • Author(s): Yoshimoto M, Kurihara H, Honda N, Kawai K, Ohe K, Fujii H, Itami J, Arai Y.
  • Journal Title: Nuclear Medicine and Biology Volume: 40 Issue: 5 Pages: 625-629
  • DOI: 10.1016/j.nucmedbio.2013.02.010
  • Peer Reviewed
• [Journal Article] Kinetic analyses of trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid transport in Xenopus laevis oocytes expressing human ASCT2 and SNAT2. (2013)
  • Author(s): Okudaira H, Nakanishi T, Oka S, Kobayashi M, Tamagami H, Schuster DM, Goodman MM, Shirakami Y, Tamai I, Kawai K.
  • Journal Title: Nuclear Medicine and Biology Volume: 40 Issue: 5 Pages: 670-675
  • DOI: 10.1016/j.nucmedbio.2013.03.009
  • Peer Reviewed
• [Journal Article] The Usefulness of 18F-FDG PET/MRI Fusion Image in Diagnosing Pancreatic Tumor: Comparison with 18F-FDG PET/CT. (2013)
  • Author(s): Nagamachi S., Nishii R., Wakamatsu H., Mizutani Y., Kiyohara S., Fujita S., Futami S., Sakae T., Furukoji E., Tamura S., Arita H., Chijiiwa K., Kawai K.
  • Journal Title: Ann. Nucl. Med. Volume: 27(6) Issue: 6 Pages: 554-563
  • DOI: 10.1007/s12149-013-0719-3
  • NAID: 10031189359
  • Peer Reviewed
• [Journal Article] Binding of Sulforhodamine B to Human Serum Albumin: A Spectroscopic Study. (2013)
  • Author(s): Kitamura M., Murakami K., Yamada K., Kawai K., Kunishima M.
  • Journal Title: Dyes and Pigments. Volume: 99(3) Pages: 588-593
  • Peer Reviewed
• [Journal Article] Diagnostic usefulness of an amino acid tracer, α-[N-methyl- ^11C]-methylaminoisobutyric acid ( ^<11>C-MeAIB), in the PET diagnosis of chest malignancies (2013)
  • Author(s): Nishii R, Higashi T, Kagawa S, Kishibe Y, Takahashi M, Yamauchi H, Motoyama H, Kawakami K, Nakaoku T, Nohara J, Okamura M, Watanabe T, Nakatani K, Nagamachi S, Tamura S, Kawai K, Kobayashi M
  • Journal Title: Ann Nucl Med Volume: 27(9) Issue: 9 Pages: 808-21
  • DOI: 10.1007/s12149-013-0750-4
  • Peer Reviewed
• [Journal Article] Arterial 18F-Fluorodeoxyglucose Uptake Reflects Balloon Catheter-Induced Thrombus Formation and Tissue Factor Expression via Nuclear Factor-κB in Rabbit Atherosclerotic Lesions. (2013)
  • Author(s): Yamashita A., Zhao Y., Zhao S., Matsuura Y., Sugita C., Iwakiri T., Okuyama N., Ohe K., Koshimoto C., Kawai K., Tamaki N., Kuge Y., Asada Y.
  • Journal Title: Circ. J. Volume: 77(10) Pages: 2626-2635
  • Peer Reviewed
• [Journal Article] Comparative Evaluation of Transport Mechanisms of Trans-1-amino-3-[18F]fluorocyclobutane- carboxylic Acid and L-[Methyl-11C]methionine in Human Glioma Cell Lines. (2013)
  • Author(s): Ono M., Oka S., Okudaira H., Schuster D.M., Goodman M.M., Kawai K., Shirakami Y.
  • Journal Title: Brain Res. Volume: 1535 Pages: 24-37
  • DOI: 10.1016/j.brainres.2013.08.037
  • Peer Reviewed
• [Journal Article] Prototype Imaging Protocols for Monitoring the Efficacy of Iodine-131 Ablation in Differentiated Thyroid Cancer. (2013)
  • Author(s): Kobayashi M., Wakabayashi H., Kojima H., Konishi T., Okuda K., Yoneyama H., Kayano D., Tobisaka M., Tsushima H., Onoguchi M., Kawai K., Kinuya S.
  • Journal Title: Hell. J. Nucl. Med. Volume: 16(3) Pages: 175-180
  • Peer Reviewed
• [Journal Article] A diclofenac suppository-nabumetone combination therapy for arthritic pain relief and a monitoring method for the diclofenac binding capacity of HSA site II in rheumatoid arthritis (2013)
  • Author(s): Nao Setoguchi, Norito Takamura, Ken-ichi Fujita, Kenji Ogata, Jin Tokunaga, Toyotaka Nishio, Etsuo Chosa, Kazuhiko Arimori, Keiichi Kawai, Ryuichi Yamamoto
  • Journal Title: Biopharmaceutics & Drug Disposition Volume: 34 (2) Issue: 2 Pages: 125-136
  • DOI: 10.1002/bdd.1829
  • Peer Reviewed
• [Journal Article] Pharmacokinetic Alteration of 99mTc-MAG3 using Serum Protein Binding Displacement Method. (2013)
  • Author(s): K Nishi, M Kobayashi, R Nishii, N Shikano, N Takamura, N Kuga, K Yamasaki, S Nagamachi, S Tamura, M Otagiri, K Kawai.
  • Journal Title: Nucl Med Biol Volume: 40 Issue: 3 Pages: 366-370
  • DOI: 10.1016/j.nucmedbio.2012.12.002
  • Peer Reviewed
• [Journal Article] N-Isopropyl-p-iodoamphetamine Hydrochloride (IMP) is Predominantly Metabolized by CYP2C19. (2012)
  • Author(s): Fujita K., Sugiyama M., Akiyama Y., Hioki K., Kunishima M., Nishi K., Kobayashi M., Kawai K., Sasaki Y.
  • Journal Title: Drug Metab. Dispos. Volume: 40 Issue: 5 Pages: 843-846
  • DOI: 10.1124/dmd.111.043893
  • Peer Reviewed
• [Journal Article] Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions. (2012)
  • Author(s): Arakawa H, Nakanishi T, Yanagihara C, Nishimoto T, Wakayama T, Mizokami A, Namiki M, Kawai K, Tamai I.
  • Journal Title: Biochem Pharmacol Volume: 84 Issue: 8 Pages: 1070-1077
  • DOI: 10.1016/j.bcp.2012.07.026
  • NAID: 120004997008
  • Peer Reviewed
• [Journal Article] Transport mechanism of (11)C-labeled L- and D-methionine in human-derived tumor cells. (2012)
  • Author(s): M Kobayashi, F Hashimoto, K Ohe, T Nadamura, K Nishi, N Shikano, R Nishii, T Higashi, H Okazawa, K Kawai.
  • Journal Title: Nucl Med Biol Volume: 39 Issue: 8 Pages: 1213-1218
  • DOI: 10.1016/j.nucmedbio.2012.06.006
  • Peer Reviewed
• [Journal Article] Down-regulation of Calcium/calmodulin-dependent Protein Kinase Kinase 2 by Androgen Deprivation Induces Castration-resistant Prostate Cancer. (2012)
  • Author(s): Shima T., Mizokami A., Miyagi T., Kawai K., Izumi K., Kumaki M., Ofude M., Zhang J., Keller E.T., Namiki M.
  • Journal Title: Prostate Volume: 72 Issue: 16 Pages: 1789-1801
  • DOI: 10.1002/pros.22533
  • Peer Reviewed
• [Presentation] Transport Mechanism of the Amino Acid Positron Emission Tomography Tracer [18F]Fluciclovine and its Application to Glioma Diagnosis. (2014)
  • Author(s): Ono M., Doi Y., Oka S., Okudaira H., Schuster D.M., Goodman M.M., Matsumoto H. Kawai K., Shirakami Y
  • Organizer: 19th North American ISSX Meeting / 29th JSSX Meeting
  • Place of Presentation: Hilton San Francisco, San Francisco, California, U.S.A
  • Year and Date: 2014-10-19
• [Presentation] Pharmacokinetics and Anti-tumor Activity of AY002 with High Affinity to EGFR-TK. (2014)
  • Author(s): Yoshimoto M., Kimura S., Hirata M., Ohmomo Y., Kawai K., Fujii H.
  • Organizer: The Society of Nuclear Medicine 61th Annual Meeting
  • Place of Presentation: Renaissance St. Louis Grand Hotel, St. Louis, Missouri, U.S.A.
  • Year and Date: 2014-06-07
• [Presentation] Radiosynthesis of [18F]FPYBF-2, a Novel PET Imaging Probe for β-Amyloid Plaques in Brain. (2014)
  • Author(s): Kagawa S., Nishii R., Higashi T., Yamauchi H., Kawai K., Watanabe H., Kimura H., Ono M., Saji H.
  • Organizer: The Society of Nuclear Medicine 61th Annual Meeting
  • Place of Presentation: Renaissance St. Louis Grand Hotel, St. Louis, Missouri, U.S.A.
  • Year and Date: 2014-06-07
• [Presentation] Introduction of Radiobromine Labeled Decalinvesamicol Analogue as a New and Promising PET Vesicular Acetylcholine Transporter (VAChT) Imaging Probe. (2014)
  • Author(s): Azim M.A., Kosaka T., Uno I., Miwa D., Kitamura Y., Ogawa K., Kawai K., Kiyono Y., Shiba K.
  • Organizer: The Society of Nuclear Medicine 61th Annual Meeting
  • Place of Presentation: Renaissance St. Louis Grand Hotel, St. Louis, Missouri, U.S.A.
  • Year and Date: 2014-06-07
• [Presentation] Increased Metabolite Levels of Glycolysis and Pentose Phosphate Pathway in Rabbit Atherosclerotic Arteries and Hypoxic Macrophage. (2014)
  • Author(s): Yamashita A., Zhao Y., Matsuura Y., Yamasaki K., Moriguchi-Goto S., Iwakiri T., Okuyama N., Koshimoto C., Kawai K., Tamaki N., Zhao S., Kuge Y., Asada Y.
  • Organizer: Arteriosclerosis, Thrombosis and Vascular Biology
  • Place of Presentation: Sheraton Centre Toronto Hotel, Toronto, Canada
  • Year and Date: 2014-05-01
• [Presentation] 18F-FDG Uptake Reflects Thrombus Formation and Tissue Factor Expression via Nuclear Factor-κB in Rabbit Atherosclerotic Lesions. (2012)
  • Author(s): Yamashita A., Zhao Y., Zhao S., Matsuura Y., Sugita C., Iwakiri T., Ohe K., Koshimoto C., Kawai K., Tamaki N., Kuge Y., Asada Y.
  • Organizer: American Heart Association Scientific Sessions 2012
  • Place of Presentation: Los Angeles Convention Center (USA)
• [Presentation] Synthesis and Evaluation of Iodinated Cyclopropanecarboxylic Acid {3-[6-(Phenylamino)- pyrimidin-4-ylamino]-phenyl}-amides as EGFR-TK Imaging Agents.
  • Author(s): Yoshimoto M., Kimura S., Yamada K., Hirata M., Ohmomo Y., Kunishima M., Kawai K., Fujii H.
  • Organizer: 20th International Symposium on Radiopharmaceutical Sciences
  • Place of Presentation: Jeju International Convention Center (Korea)
• [Presentation] Radiosynthesis of [18F]Fluoroacetate by a One-pot Distillation Procedure: A Novel Approach of the Solid-phase Synthesis.
  • Author(s): Kagawa S., Nishii R., Higashi T., Yamauchi H., Takemoto K., Hatano E., Tachibana A., Takahashi K., Mizuma H., Onoe H., Nagamachi S., Kawai K., Tamura S.
  • Organizer: 20th International Symposium on Radiopharmaceutical Sciences
  • Place of Presentation: Jeju International Convention Center (Korea)
• [Presentation] Development of Novel EGFR-TK Imaging Agents based on Anilinopyrimidine Structure.
  • Author(s): Yoshimoto M., Kimura S., Hirata M., Ohmomo Y., Kawai K., Fujii H.
  • Organizer: The Society of Nuclear Medicine 60th Annual Meeting
  • Place of Presentation: Vancouver Convention Centre (Canada)
• [Presentation] Novel Approach for Solid-phase Radiosynthesis of 18F-Fluoroacetate: Comparison between One-pot and Two-pot Distillation Procedure.
  • Author(s): Kagawa S., Nishii R., Higashi T., Yamauchi H., Takemoto K., Tachibana A., Takahashi K., Mizuma H., Onoe H., Kawai K.
  • Organizer: The Society of Nuclear Medicine 60th Annual Meeting
  • Place of Presentation: Vancouver Convention Centre (Canada)
• [Presentation] The Development of Potential Vesicular Acetylcholine Transporter (VAChT) PET Imaging Probes.
  • Author(s): Kosaka T., Miwa D., Uno I., Kitamura Y., Azim M.A., Ogawa K., Kinuya S., Kawai K., Shiba K.
  • Organizer: The Society of Nuclear Medicine 60th Annual Meeting
  • Place of Presentation: Vancouver Convention Centre (Canada)
• [Presentation] In vivo Evaluation of Radioiodinated o-Iodo-trans-decalinvesamicol (OIDV) as a Vesicular Acetylcholine Transporter (VAChT ) Imaging Agent.
  • Author(s): Uno I., Kosaka T., Kitamura Y., Miwa D., Azim M.A., Ogawa K., Kawai K., Taki J., Kinuya S., Shiba K.
  • Organizer: The Society of Nuclear Medicine 60th Annual Meeting
  • Place of Presentation: Vancouver Convention Centre (Canada)
• [Presentation] Comparison between a High- and Medium-energy Collimator for Na131I Imaging of Differentiated Thyroid Cancer.
  • Author(s): Kobayashi M., Wakabayashi H., Kayano D., Nishi K., Onoguchi M., Kawai K., Kinuya S.
  • Organizer: The Society of Nuclear Medicine 60th Annual Meeting
  • Place of Presentation: Vancouver Convention Centre (Canada)
• [Presentation] Development of Ultra-high-resolution Pinhole Collimator for Small-animal SPECT with CZT Detector.
  • Author(s): Nishi K., Kobayashi M., Matsunari I., Miyazaki Y., Shiba K., Kawai K., Kinuya S.
  • Organizer: The Society of Nuclear Medicine 60th Annual Meeting
  • Place of Presentation: Vancouver Convention Centre (Canada)
• [Presentation] Transport Mechanism of Trans-1-amino-3-18F-fluorocyclobutanecarboxylic Acid (18F-FACBC) PET Radiotracer in Human Prostate Cancer.
  • Author(s): Okudaira H., Oka S., Nakanishi T., Kobayashi M., Tamagami H., Schuster D.M., Goodman M.M., Shirakami Y., Tamai I., Kawai K.
  • Organizer: The Society of Nuclear Medicine 60th Annual Meeting
  • Place of Presentation: Vancouver Convention Centre (Canada)
• [Presentation] System A Amino Acid Transport C-11 MeAIB PET/CT Imaging for Diagnosing Prostate Cancer.
  • Author(s): Nishii R., Higashi T., Kagawa S., Kishibe Y., Takahashi M., Kobayashi M., Nagamachi S., Mizutani Y., Kawai K., Tamura S.
  • Organizer: World Molecular Imaging Congress 2013
  • Place of Presentation: Savannah International Trade & Convention Centre (USA)
• [Presentation] Correlations between FDG Uptake Indices and the Expression of Various Type Oncogenes (KRAS, BRAF, HIF-1, EGFR, CDH13, p53, Ki67, Glut 1 and Glut 3) in Biliary Cancer: A Comparison Study to MRI Diffusion Weighted Image Parameters.
  • Author(s): Nagamachi S., Nishii R., Mizutani Y., Kiyohara S., Shibata N., Kondo K., Kai M., Tamura S., Chijiiwa K., Kawai K., Fujita S., Wakamatsu H., Futami S.
  • Organizer: Radiological Society of North America 2013, 99th Scientific Assembly and Annual Meeting
  • Place of Presentation: McCormick Place, Chicago (USA)
• [Presentation] The Correlation between SUVmax of 18F-FDG PET/CT and Apparent Diffusion Coefficients (ADC) in Pancreas Cancer and Biliary Cancer?
  • Author(s): Nagamachi S., Nishii R., Mizutani Y., Kiyohara S., Furukoji E., Sakae T., Tamura S., Wakamatsu H., Fujita S., Futami S., Kawai K.
  • Organizer: Radiological Society of North America 2013, 99th Scientific Assembly and Annual Meeting
  • Place of Presentation: McCormick Place, Chicago (USA)
• [Presentation] Evaluation of Radioiodinated PYK for Monitoring Active Mutation of EGFR-TK.
  • Author(s): Yoshimoto M., Hirata M., Magata Y., Nishii R., Kawai K., Ohmomo Y.
  • Organizer: The Society of Nuclear Medicine 59th Annual Meeting
  • Place of Presentation: Miami Beach Convention Center (USA)
• [Presentation] Accumulation Mechanism of 11C Labeled D-Methionine in Human-Derived Tumor Cells: Comparison with Gene Expression of Amino Acid Transporter System.
  • Author(s): Kobayashi M., Hashimoto F., Ohe K., Nadamura T., Nishi K., Okudaira H., Higashi T., Shikano N., Nishii R., Kawai K.
  • Organizer: The Society of Nuclear Medicine 59th Annual Meeting
  • Place of Presentation: Miami Beach Convention Center (USA)
• [Presentation] Assessment of Efficacy of [11C]MeAIB PET/CT as a Biomarker of the System A Amino Acid Transport: Comparison with [18F]FDG and MRI in the Patients with Prostate Cancer.
  • Author(s): Higashi T., Nishii R., Kagawa S., Takahashi M., Kishibe Y., Yamauchi H., Ishitoya S., Oonishi H., Kawai K., Kobayashi M.
  • Organizer: The Society of Nuclear Medicine 59th Annual Meeting
  • Place of Presentation: Miami Beach Convention Center (USA)
• [Presentation] Imaging Acquisition and Processing Protocols during Iodine-131 Therapy for Differentiated Thyroid Cancer.
  • Author(s): Kobayashi M., Wakabayashi H., Kojima H., Konishi T., Okuda K., Kayano D., Tobisaka M., Onoguchi M., Kawai K., Kinuya S.
  • Organizer: The Society of Nuclear Medicine 59th Annual Meeting
  • Place of Presentation: Miami Beach Convention Center (USA)
• [Presentation] Usefulness of System A Amino Acid Transport PET Imaging with C-11-MeAIB in Diagnosing Brain Tumors: A Comparison Study with C-11-Methionine PET Imaging.
  • Author(s): Nishii R., Higashi T., Kagawa S., Kishibe Y., Takahashi M., Kobayashi M., Ohe K., Kawai K., Nagamachi S., Tamura S.
  • Organizer: The Society of Nuclear Medicine 59th Annual Meeting
  • Place of Presentation: Miami Beach Convention Center (USA)
• [Presentation] Mechanism of Hepatic Uptake Transport and Bile Excretion in Hepatobiliary Scintigraphy with A 99mTc Labeled Pyridoxylaminate Group.
  • Author(s): Kobayashi M., Ohe K., Nadamura T., Nishi K., Higashi T., Okudaira H., Shikano N., Nishii R., Kawai K.
  • Organizer: The Society of Nuclear Medicine 59th Annual Meeting
  • Place of Presentation: Miami Beach Convention Center (USA)
• [Presentation] The Usefulness of 18F-PET/MRI Fusion Image in Diagnosing Pancreatic Tumor: Comparison with 18F-FDG PET/CT.
  • Author(s): Nagamachi S., Nishii R., Mizutani Y., Kiyohara S., Wakamatsu H., Fujita S., Futami S., Tamura S., Kawai K.
  • Organizer: The Society of Nuclear Medicine 59th Annual Meeting
  • Place of Presentation: Miami Beach Convention Center (USA)
• [Presentation] 薬物動態解析に特化した小動物用インビボ分子イメージング装置の開発
  • Author(s): 川井恵一
  • Organizer: 石川県産業創出支援機構 平成24年度医療機器開発マッチングフォーラム
  • Place of Presentation: 金沢大学 （石川県）
  • Invited
• [Book] 「放射線関係法規概説 －医療分野も含めて－」（第５版） (2013)
  • Author(s): 川井恵一
  • Total Pages: 222
  • Publisher: 通商産業研究社
• [Remarks] 金沢大学医薬保健研究域保健学系 量子医療技術学講座 川井研究室
  • URL: http://kawai.w3.kanazawa-u.ac.jp/index.html
• [Remarks] 金沢大学 研究者情報
  • URL: http://ridb.kanazawa-u.ac.jp/public/detail.php?id=2789&page=1&search=1&keyword=%E5%B7%9D%E4%BA%95&andor=AND&tgt1=1&tgt2=&tgt3=&tgt4=
• [Remarks] 金沢大学医薬保健研究域保健学系 量子医療技術学講座 川井研究室
  • URL: http://kawai.w3.kanazawa-u.ac.jp/index.html
• [Remarks] 金沢大学 研究紹介
  • URL: http://ridb.kanazawa-u.ac.jp/public/detail.php?id=2789&page=1&search=1&keyword=%E5%B7%9D%E4%BA%95&andor=AND&tgt1=1&tgt2=&tgt3=&tgt4=
• [Remarks] 金沢大学 研究紹介データベース
  • URL: http://ridb.kanazawa-u.ac.jp/public/detail.php?id=2789&page=1&search=1&keyword=%E5%B7%9D%E4%BA%95%E3%80%80%E6%83%A0%E4%B8%80&andor=AND&tgt1=1&tgt2=&tgt3=&tgt4=
• [Remarks] 金沢大学医薬保健研究域保健学系 量子医療技術学講座 川井研究室
  • URL: http://kawai.w3.kanazawa-u.ac.jp/index.html