| Project/Area Number |
24659560
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | University of Fukui |
|---|
Principal Investigator |
KIYONO Yasushi 福井大学, 高エネルギー医学研究センター, 教授 (50305603)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MORI Tetsuya 福井大学, 高エネルギー医学研究センター, 助教 (40397287)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 放射線 / 放射性医薬遺品 / グリア / PET / 放射性医薬品 |
|---|
| Research Abstract |
It is expected to develop imaging probes for glial function. Therefore, in this study, F-18 labeled acetic acid derivative, F-18 labeled fluoroacetate was evaluated as an imaging probe for glial function.
In in vitro cell uptake experiments, it was observed that F-18 labeled fluoroacetate was uptaken into astocytes. On the other hand, F-18 labeled fluoroacetate was not uptaken into microglia. In PET imaging experiments, the accumulation of F-18 labeled fluoroacetate in the brain was peaked at 3 min post injection, and then the radioactivity was maintained in the same level.
These results suggest that F-18 labeled fluoroacetae has the possibility to image the glial function and to measure the energetic metabolism in the glia.
|
