| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Nearly 60% of human adult body comprised of water. There are various kinds of "fluid space" such as, blood pool, cerebrospinal fluid, eye ball, inner ear, saliva, intentine, lymph fluid and so on. Each space has blood-space barrier. These barriers regulate the distribution of drugs and chemicals. We developed the method to evaluate the function of these barriers in vivo, using easy and non-invasive magnetic resonance imaging technique, which is developed by us. We evaluated the unique features of each space using MR technique and gadolinium based contrast materials.We clarified the drug pharmacokinetics of various spaces.
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