Development of high-sensitive magnetic resonance imaging technique to visualize and quantify drug kinetics in various fluid spaces in human body
Project/Area Number |
24659562
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Radiation science
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Research Institution | Nagoya University |
Principal Investigator |
NAGANAWA Shinji 名古屋大学, 医学(系)研究科(研究院), 教授 (50242863)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 脳脊髄液 / 磁気共鳴画像 / 造影剤 / メニエール病 / 膵液 |
Outline of Final Research Achievements |
Nearly 60% of human adult body comprised of water. There are various kinds of "fluid space" such as, blood pool, cerebrospinal fluid, eye ball, inner ear, saliva, intentine, lymph fluid and so on. Each space has blood-space barrier. These barriers regulate the distribution of drugs and chemicals. We developed the method to evaluate the function of these barriers in vivo, using easy and non-invasive magnetic resonance imaging technique, which is developed by us. We evaluated the unique features of each space using MR technique and gadolinium based contrast materials.We clarified the drug pharmacokinetics of various spaces.
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Report
(4 results)
Research Products
(84 results)
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[Journal Article] Evaluation of 11C-choline PET/CT for primary diagnosis and staging of urothelial carcinoma of the upper urinary tract: a pilot study2014
Author(s)
Naoto Sassa, Katsuhiko Kato, Shinji Abe, Shingo Iwano, Shinji Ito, Mitsuru Ikeda, Kazuhiro Shimamoto, Seiichi Yamamoto, Tokunori Yamamoto, Momokazu Gotoh, Shinji Naganawa
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Journal Title
Eur J Nucl Med Mol Imaging
Volume: 41(12)
Issue: 12
Pages: 2232-2241
DOI
Related Report
Peer Reviewed
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[Journal Article] Prognostic Impact of Combined Late Gadolinium Enhancement on Cardiovascular Magnetic Resonance and Peak Oxygen Consumption in Ambulatory Patients with Nonischemic Dilated Cardiomyopathy2014
Author(s)
Takashi Yamada, Akihiro Hirashiki, Takahiro Okumura, Shiro Adachi, Shuzo Shimazu, Shinya Shimizu, Ryota Morimoto, Kyosuke Takeshita, Shinji Naganawa, Takahisa Kondo, Toyoaki Murohara
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Journal Title
Journal of Cardiac Failure
Volume: 20(11)
Pages: 825-832
Related Report
Peer Reviewed
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[Journal Article] Endolymphatic space size in patients with vestibular migraine and Meniere's disease.2014
Author(s)
Nakada T, Yoshida T, Suga K, Kato M, Otake H, Kato K, Teranishi M, Sone M, Sugiura S, Kuno K, Pyykko I, Naganawa S, Watanabe H, Sobue G, Nakashima T.
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Journal Title
J Neurol.
Volume: 261(11)
Issue: 11
Pages: 2079-2084
DOI
Related Report
Peer Reviewed
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[Journal Article] Endolymphatic hydrops revealed by magnetic resonance imaging in patients with acute low-tone sensorineural hearing loss.2013
Author(s)
Mariko Shimono, Masaaki Teranishi, Tadao Yoshida, Masahiro Kato, Rui Sano, Hironao Otake, Ken Kato, Michihiko Sone, Naoki Ohmiya, Shinji Naganawa, Tsutomu Nakashima
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Journal Title
Otol Neurotol.
Volume: 34(7)
Issue: 7
Pages: 1241-1246
DOI
Related Report
Peer Reviewed
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