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Basic research for the optimization of stereotactic radiotherapy

Research Project

Project/Area Number 24659563
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionKyoto University

Principal Investigator

ITASAKA SATOSHI  京都大学, 医学(系)研究科(研究院), 非常勤講師 (90378654)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords放射線治療 / 腫瘍内低酸素 / 定位放射線治療
Outline of Final Research Achievements

In this study, changes of intra-tumoral hypoxia, HIF-1 activity, and vasculature after a large dose single irradiation were evaluated, sequentially. Effects of large dose irradiation on tumors and normal tissues were evaluated at the same time. It was also tried to find factors that enhance the therapeutic effects. Human lung cancer cell line H441 transfected with HIF-1 responsible luciferase gene were implanted into the nude mice, subcutaneously. The temporal changes of intra-tumoral hypoxia were observed as HIF-1 activity change by optical imaging. Optimal timing of the second irradiation was evaluated using the HIF-1 imaging to maximize the therapeutic effects of irradiation. We could not identify new therapeutic targets that can enhance the effect of radiation therapy.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (5 results)

All 2015 2014 2013

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 3 results)

  • [Journal Article] UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1alpha2015

    • Author(s)
      Goto Y, Zeng L, YeomCJ, Zhu Y, Morinibu A, Shinoyam K, Kobayashi M, Hirota K, Itasaka S, Yoshimura M, Tanimoto K, Sowa T, Menju T, Sonobe M, Kakeya H, Toi M, Date H, Hammond EM, Hiraoka M, Harada H.
    • Journal Title

      Nat Commun

      Volume: 6 Issue: 1 Pages: 1-10

    • DOI

      10.1038/ncomms7153

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aberrant IDH3α expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis.2014

    • Author(s)
      Zeng L, Morinibu A, Kobayashi M, Zhu Y, Wang X, Goto Y, Yeom CJ, Zhao T,Hirota K, Shinomiya K, Itasaka S, Yoshimura M, Guo G, Hammond EM, Hiraoka M, Harada H.
    • Journal Title

      Oncogene

      Volume: epub Issue: 36 Pages: 4758-4766

    • DOI

      10.1038/onc.2014.411

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] HIF-1-mediated metabolic reprogramming reduces ROS levels and facilitates the metastatic colonization of cancers in lungs.2014

    • Author(s)
      1. Zhao T, Zhu Y, Morinibu A, Kobayashi M, Shinomiya K, Itasaka S, Yoshimura M, Guo G, Hiraoka M, Harada H.
    • Journal Title

      Scientific Reports

      Volume: 4.3793 Issue: 1 Pages: 1-7

    • DOI

      10.1038/srep03793

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Microenvironment and radiation therapy2013

    • Author(s)
      M Yoshimura, S Itasaka, H Harada,
    • Journal Title

      Biomed Res Int

      Volume: 2013 Pages: 685308-685308

    • DOI

      10.1155/2013/685308

    • NAID

      120005243745

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of novel orthotopic nude mouse models for human small-cell lung cancer2013

    • Author(s)
      T Isobe, A Onn, D Morgensztern, JJ Jacoby, W Wu, T Shintani, S Itasaka, K Shibuya, PJ Koo, MS O'Reilly, RS Herbst
    • Journal Title

      J Thorac Oncol

      Volume: 8(2) Issue: 2 Pages: 140-6

    • DOI

      10.1097/jto.0b013e3182725ff9

    • Related Report
      2012 Research-status Report
    • Peer Reviewed

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Published: 2013-05-31   Modified: 2019-07-29  

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