Enhancement of the antitumor effect of radiation therapy combined with transcutaneous application of CO2 in human sarcoma
| Project/Area Number |
24659565
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWAMOTO Teruya 神戸大学, 大学院医学研究科, 助教 (30420558)
HARA Hitomi 神戸大学, 医学部付属病院, 助教 (40437489)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | 骨軟部腫瘍 / 放射線治療 / 炭酸ガス / 放射線 / 悪性腫瘍 |
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| Outline of Final Research Achievements |
The purpose of the current study was to evaluate the effects of transcutaneous CO2 therapy on the antitumor efficacy of X-ray irradiation using MFH. In the in vivo study using an animal model in which MFH cells (Nara-H) were transplanted, tumor volume in the combination group (transcutaneous CO2+X-ray) was reduced to 28%, 42% and 47% of that in the control, CO2 alone, and X-ray alone groups respectively. Apoptotic activity and ROS production in the combination group were strongly increased with decreasing HIF-1α expression relative to the control, CO2and X-ray groups. The transcutaneous CO2 system enhanced the antitumor action of X-ray irradiation and could be a novel therapeutic tool for overcoming radioresistance in human malignancies.
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Report
(5 results)
Research Products
(6 results)
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[Presentation] 悪性腫瘍の炭酸ガス経皮吸収の感受性の差異の検討2015
Author(s)
上羽 岳志, 酒井 良忠, 河本 旭哉, 大西 康央, 原田 理沙, 蓑田 正也, 戸田 光紀, 原 仁美, 黒坂 昌弘, 秋末 敏宏
Organizer
第30回日本整形外科学会基礎学術集会
Place of Presentation
富山国際会議場(富山県富山市）
Year and Date
2015-10-22
Related Report
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[Presentation] The effects of reoxygenation using a novel CO2 therapy on radiosensitivity in human malignant fibrous histiocytoma cells.2013
Author(s)
Onishi Y, Kawamoto T, Ueha T, Hara H, Toda M, Harada R, Minoda M, Morishita M, Kurosaka M, Akisue T.
Organizer
8th Combined Meeting of the Orthopaedic Research Societies
Place of Presentation
Venice, Italy
Related Report
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