Therapy using alpha-emitting radionuclide
| Project/Area Number |
24659573
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Kyoto College of Medical Science |
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Principal Investigator |
ENDO keigo 京都医療科学大学, 公私立大学の部局等, 学長 (10115800)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Naoyuki 群馬県立県民健康科学大学, 公私立大学の部局等, 教授 (90311381)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | がん治療 / アルファ線 / 抗体 / ベータ線 / ＲＩ内用治療 / 放射線管理 / アスタチン211 / ＲＩ内用療法 / RI内用療法 / MIBG |
|---|
| Research Abstract |
Alpha-emitter;Astatin-211(half-life 7 hours), produced by using cyclotron, can be clinically applied for the therapy of cancer patients under current regulation in Japan. For further development of alpha-emitter therapy of cancer, the establishment of production system using cyclotron, relaxation of strict regulation, and the delivery of the alpha-emitter to research institutes will be useful in Japan.
Anti-tumor antibodies were labeled with beta-emitter yttrium-90 (half-life 3 days), injected into the tumor-bearing mice repeatedly, and showed inhibition of tumor progression. Animal-tumor model, established in the present study, would be used for the basic studies of alpha-emitter therapy of cancer.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Assessment of [^<18>F]-fluoracetate PET/CT as a tumor-imaging modality : Preclinical study in healthy volunteers and clinical evaluation in patients with liver tumor2014
Author(s)
Takemoto K, Hatano E, Nishii R, Kagawa S, Kishibe Y, Takahashi M, Yamauchi H, Matsumura K,Zaima M, Toriguchi K, Tanabe K, Kitamura K, Seo S, Taura K, Endo K, Uemoto S, Higashi T
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Journal Title
Ann Nucl Med
Volume: 28(4)
Pages: 371-381
Related Report
Peer Reviewed
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[Journal Article] Transport of 3-fluoro-L-α-methyl-tyrosine by tumor-upregulated L-type amino acid transporter 1: a cause of the tumor uptake in PET.2012
Author(s)
Wiriyasermkul P, Nagamori S, Tominaga H, Oriuchi N, Kaira K, Nakao H, Kitashoji T, Ohgaki R, Tanaka H, Endou H, Endo K, Sakurai H, Kanai Y.
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Journal Title
J Nucl Med
Volume: 53
Pages: 1253-1261
DOI
Related Report
Peer Reviewed
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[Journal Article] In vivo therapeutic effect of CDH3/P-cadherin-targeting radioimmunotherapy2012
Author(s)
Yoshioka H, Yamamoto S, Hanaoka H, Iida Y, Paudyal P, Higuchi T, Tominaga H, Oriuchi N, Nakagawa H, Shiba Y, Yoshida K, Osawa R, Katagiri T, Tsunoda T, Nakamura Y, Endo K
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Journal Title
Cancer Immunol. Immunother.
Volume: 61
Pages: 1211-1220
DOI
Related Report
Peer Reviewed
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