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Therapy using alpha-emitting radionuclide

Research Project

Project/Area Number 24659573
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionKyoto College of Medical Science

Principal Investigator

ENDO keigo  京都医療科学大学, 公私立大学の部局等, 学長 (10115800)

Co-Investigator(Kenkyū-buntansha) WATANABE Naoyuki  群馬県立県民健康科学大学, 公私立大学の部局等, 教授 (90311381)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsがん治療 / アルファ線 / 抗体 / ベータ線 / RI内用治療 / 放射線管理 / アスタチン211 / RI内用療法 / RI内用療法 / MIBG
Research Abstract

Alpha-emitter;Astatin-211(half-life 7 hours), produced by using cyclotron, can be clinically applied for the therapy of cancer patients under current regulation in Japan. For further development of alpha-emitter therapy of cancer, the establishment of production system using cyclotron, relaxation of strict regulation, and the delivery of the alpha-emitter to research institutes will be useful in Japan.
Anti-tumor antibodies were labeled with beta-emitter yttrium-90 (half-life 3 days), injected into the tumor-bearing mice repeatedly, and showed inhibition of tumor progression. Animal-tumor model, established in the present study, would be used for the basic studies of alpha-emitter therapy of cancer.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report

Research Products

(19 results)

All 2014 2013 2012

All Journal Article (16 results) (of which Peer Reviewed: 16 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Invited: 1 results)

  • [Journal Article] Fractionated radioimmunotherapy with 90Y-labeled fully human anti-CEA antibody.2014

    • Author(s)
      Hanaoka H, Kuroki M, Yamaguchi A, Achmad A, Iida Y, Higuchi T, Oriuchi N, Endo K
    • Journal Title

      Cancer Biotherapy & Radiopharmaceuticals

      Volume: 29 Pages: 70-76

    • DOI

      10.1089/cbr.2013.1562

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Assessment of [^<18>F]-fluoracetate PET/CT as a tumor-imaging modality : Preclinical study in healthy volunteers and clinical evaluation in patients with liver tumor2014

    • Author(s)
      Takemoto K, Hatano E, Nishii R, Kagawa S, Kishibe Y, Takahashi M, Yamauchi H, Matsumura K,Zaima M, Toriguchi K, Tanabe K, Kitamura K, Seo S, Taura K, Endo K, Uemoto S, Higashi T
    • Journal Title

      Ann Nucl Med

      Volume: 28(4) Pages: 371-381

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of vascular endothelial growth factor in colon cancer xenografts using bevacizumab based near infrared fluorophore conjugate2014

    • Author(s)
      Paudyal B, Paudyal P, Shah D, Tominaga H, Tsushima Y, Endo K
    • Journal Title

      J Biomed Sci

      Volume: 21(1) Pages: 21-35

    • DOI

      10.1186/1423-0127-21-35

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of vascular endothelial growth factor in colon cancer xenografts using bevacizumab based near infrared fluorophore conjugate.2014

    • Author(s)
      Paudyal B, Paudyal P, Shah D, Tominaga H, Tsushima Y, Endo K.
    • Journal Title

      J Biomed Sci

      Volume: Epub ahead

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fatty Acid Binding Protein 4 and 5 Play a Crucial Role in Thermogenesis under the Conditions of Fasting and Cold Stress2014

    • Author(s)
      Syamsunarno MR, Matsui H, 他12名
    • Journal Title

      Plos One

      Volume: 9(3) Pages: 90825-90825

    • DOI

      10.1371/journal.pone.0090825

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] An Integrated Teaching Method of Gross Anatomy and Computed Tomography Radiology2014

    • Author(s)
      Tohru Murakami, Yuki Tajika, Hitoshi Ueno, Sachiko Awata, Satoshi Hirasawa, Maki Sugimoto, Yoshihiko Kominato, Yoshito Tsushima, Keigo Endo, & Hiroshi Yorifuji
    • Journal Title

      Anat Sci Educ.

      Volume: (e-published) Pages: 438-449

    • DOI

      10.1002/ase.1430

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fractionated radioimmunotherapy with Y90-labeled fully human anti-CEA antibody.2014

    • Author(s)
      Hanaoka H, Kuroki M, Yamaguchi A, Achmad A, Iida Y, Higuchi T, Oriuchi N, Tsushima Y, Endo K.
    • Journal Title

      Cancer Biother Radiopharm.

      Volume: 29(2) Pages: 70-76

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biological evaluation of 3-[18F]fluoro-α-methyl-D-tyrosine (D-[18F]FAMT) as a novel amino acid tracer for positron emission tomography.2013

    • Author(s)
      Ohshima Y
    • Journal Title

      Ann Nucl Med.

      Volume: 27 Pages: 314-24

    • DOI

      10.1007/s12149-013-0687-7

    • NAID

      10031176139

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Peroxisome Proliferator‐Activated Receptor‐γ in Capillary Endothelia Promotes Fatty Acid Uptake by Heart During Long‐Term Fasting2013

    • Author(s)
      Goto K, Iso T, Hanaoka H, Yamaguchi A, Suga T, Hattori A, Irie Y, Shinagawa Y, Matsui H, et al.
    • Journal Title

      J Am Heart Assoc

      Volume: 2(1)

    • DOI

      10.1161/jaha.112.004861

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Capillary endothelial fatty acid binding proteins 4 and 5 play a critical role in fatty acid uptake in heart and skeletal muscle2013

    • Author(s)
      Iso Tatsuya, Kurabayashi Masahiko
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: vol.33 Pages: 2549-2557

    • DOI

      10.1161/atvbaha.113.301588

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transport of 3-fluoro-L-α-methyl-tyrosine by tumor-upregulated L-type amino acid transporter 1: a cause of the tumor uptake in PET.2012

    • Author(s)
      Wiriyasermkul P, Nagamori S, Tominaga H, Oriuchi N, Kaira K, Nakao H, Kitashoji T, Ohgaki R, Tanaka H, Endou H, Endo K, Sakurai H, Kanai Y.
    • Journal Title

      J Nucl Med

      Volume: 53 Pages: 1253-1261

    • DOI

      10.2967/jnumed.112.103069

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] On personal dosimetry for members of the general public in Japan and the medical management of radiation accidents.2012

    • Author(s)
      Watanabe N, Endo K.
    • Journal Title

      Radiat Prot Dosimetry

      Volume: 149 Pages: 469-469

    • DOI

      10.1093/rpd/ncr445

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] In vivo therapeutic effect of CDH3/P-cadherin-targeting radioimmunotherapy2012

    • Author(s)
      Yoshioka H, Yamamoto S, Hanaoka H, Iida Y, Paudyal P, Higuchi T, Tominaga H, Oriuchi N, Nakagawa H, Shiba Y, Yoshida K, Osawa R, Katagiri T, Tsunoda T, Nakamura Y, Endo K
    • Journal Title

      Cancer Immunol. Immunother.

      Volume: 61 Pages: 1211-1220

    • DOI

      10.1007/s00262-011-1186-0

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Diagnostic reference level of computed tomography (CT) in Japan.2012

    • Author(s)
      Fukushima Y, Tsushima Y, Takei H, Taketomi-Takahashi A, Otake H, Endo K.
    • Journal Title

      Radiat Prot Dosimetry

      Volume: 151 Pages: 51-7

    • DOI

      10.1093/rpd/ncr441

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 国産化99Mo/99mTcの医療運用に向けての課題-研究用原子炉を用いる99Mo/99mTc国産化の課題2012

    • Author(s)
      遠藤啓吾、井戸達雄
    • Journal Title

      RADIOISOTOPES

      Volume: 1 Pages: 385-387

    • NAID

      10030780245

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Predicting cetuximab accumulation in KRAS wild-type and KRAS mutant coloretal cancer using 64Cu-labeled cetuximab positron emission tomography.2012

    • Author(s)
      Achmad A ,Hanaoka H,Yoshioka H,Yamamoto S,Tominaga H,Araki T,Ihshima Y,Oriuchi N,Endo k,
    • Journal Title

      Cancer Sci

      Volume: 103 Pages: 600-5

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Radiation Exposure and Health Effect of Radionuclides(I-131,Cs-137) Released from the Fukushima Nuclear Power Plant2014

    • Author(s)
      遠藤啓吾
    • Organizer
      第11回世界核医学会
    • Place of Presentation
      メキシコ国カンクン市
    • Related Report
      2013 Final Research Report
  • [Presentation] Fukushima Nuclear Power Plant Accident- Medical Emergency, Radiation Exposure in Residents and Workers, Food Contamination and its Monitoring -2013

    • Author(s)
      遠藤啓吾
    • Organizer
      第60回北米核医学会
    • Place of Presentation
      カナダ国バンクーバー市
    • Related Report
      2013 Final Research Report
  • [Presentation] Fukushima Nuclear Power Plant Accident- Medical Emergency Radiation Exposurein Residents and Workers, Food Contamination and its Monitoring2013

    • Author(s)
      Endo K.
    • Organizer
      第60回 米国核医学会
    • Place of Presentation
      カナダ バンクーバー市
    • Related Report
      2013 Annual Research Report
    • Invited

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Published: 2013-05-31   Modified: 2019-07-29  

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