| Project/Area Number |
24659574
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Institute of Physical and Chemical Research |
|---|
Principal Investigator |
CUI Yilong 独立行政法人理化学研究所, ライフサイエンス技術基盤研究センター, ユニットリーダー (60312229)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
WADA Yasuhiro 独立行政法人理化学研究所, ライフサイエンス技術基盤研究センター, 副チームリーダー (40382197)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | ＰＥＴ / 脳機能画像 / 神経活動 / 脳機能画像解析 / PET |
|---|
| Research Abstract |
In order to establish a novel method for a neuronal activity-dependent neuroimaging analysis, a non-metal imaging device was fabricated to record the neurophysiological changes and PET scans simultaneously. The numerical model-based attenuation correction was implemented to correct for the lower counts induced by the device. The radioactivity in the blood quickly achieved a steady state after the intravenous injection of FDG combining bolus injection and continuous infusion, whereas it was continuously increased in the brain. Moreover, the electrical stimulation-related functional neuroimages were reconstructed by a trigger driven gating method in which every 5-sec PET list mode data were sorted into a gate sinogram according to a time-stamp driven by a trigger signal which was synchronized with the electrical stimulation.
|
