Establishment of a novel method for brain activity dependent neuroimaging

• Project/Area Number: 24659574
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: CUI Yilong 独立行政法人理化学研究所, ライフサイエンス技術基盤研究センター, ユニットリーダー (60312229)
• Co-Investigator(Kenkyū-buntansha): WADA Yasuhiro 独立行政法人理化学研究所, ライフサイエンス技術基盤研究センター, 副チームリーダー (40382197)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: ＰＥＴ / 脳機能画像 / 神経活動 / 脳機能画像解析 / PET

Research Abstract

In order to establish a novel method for a neuronal activity-dependent neuroimaging analysis, a non-metal imaging device was fabricated to record the neurophysiological changes and PET scans simultaneously. The numerical model-based attenuation correction was implemented to correct for the lower counts induced by the device. The radioactivity in the blood quickly achieved a steady state after the intravenous injection of FDG combining bolus injection and continuous infusion, whereas it was continuously increased in the brain. Moreover, the electrical stimulation-related functional neuroimages were reconstructed by a trigger driven gating method in which every 5-sec PET list mode data were sorted into a gate sinogram according to a time-stamp driven by a trigger signal which was synchronized with the electrical stimulation.

Research Products

• [Journal Article] Apomorphine-induced modulation of neural activities in the ventrolateral striatum of rats (2013)
  • Author(s): Fujita S., Kato R., Cui, Y.L., Terakado M., Suga K., Koshikawa N., Kobayashi M
  • Journal Title: Synapse Volume: 67 Issue: 7 Pages: 363-373
  • DOI: 10.1002/syn.21644
  • Peer Reviewed
• [Journal Article] Functional anatomy of gustation in the alert rat revealed by positron emission tomography (2013)
  • Author(s): Kobayashi, M., Cui, Y.L.., Sako, T., Sasabe, T., Mizoguchi, N., Wada, Y., Kataoka, Y., Koshikawa, N
  • Journal Title: J Neurosci Res Volume: 91 Issue: 10 Pages: 1363-1370
  • DOI: 10.1002/jnr.23252
  • Peer Reviewed
• [Journal Article] Synthesis of an 11C-Labeled Antiprion GN8 Derivative and Evaluation of Its Brain Uptake by Positron Emission Tomography (2013)
  • Author(s): Tsutomu Kimura, Takeo Sako, Siqin, Junji Hosokawa-Muto, Yi Long Cui, Yasuhiro Wada, Yosky Kataoka, Hisashi Doi, Suehiro Sakaguchi, Masaaki Suzuki, Yasuyoshi Watanabe, Kazuo Kuwata
  • Journal Title: ChemMedChem Volume: 8(7) Issue: 7 Pages: 1035-1039
  • DOI: 10.1002/cmdc.201300167
  • Peer Reviewed
• [Journal Article] Evaluation of Oatp and Mrp2 activities in hepatobiliary excretion using newly developed positron emission tomography tracer [11C]dehydropravastatin in rats. (2013)
  • Author(s): Shingaki T, Takashima T, Ijuin R, Zhang X, Onoue T, Katayama Y, Okauchi T, Hayashinaka E, Cui Y, Wada Y, Suzuki M, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y.
  • Journal Title: J Pharmacol Exp Ther Volume: 347 Issue: 1 Pages: 193-202
  • DOI: 10.1124/jpet.113.206425
  • Peer Reviewed
• [Journal Article] Positron emission tomography study on pancreatic somatostatin receptors in normal and diabetic rats with 68Ga-DOTA-octreotide: A potential PET tracer for beta cell mass measurement (2013)
  • Author(s): Sako T, Hasegawa K, Nishimura M, Kanayama Y, Wada Y, Hayashinaka E, Cui Y, Kataoka Y, Senda M, and Watanabe Y
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 442 Issue: 1-2 Pages: 79-84
  • DOI: 10.1016/j.bbrc.2013.11.001
  • Peer Reviewed
• [Journal Article] Neuroinflammation in animal models of fatigue (2013)
  • Author(s): Kataoka, Y., Yamato, M., Miyashige, Y., Tamura, Y., Cui, Y.L
  • Journal Title: Advances in Neuroimmune Biology Volume: 4 Pages: 237-244
  • Peer Reviewed
• [Journal Article] Chronic degeneration of dorsal raphe serotonergic neurons modulates cortical spreading depression : A possible pathophysiology of migraine (2013)
  • Author(s): Cui, Y.L., Li, Q.H., Yamada, H., Watanabe, Y., Kataoka, Y
  • Journal Title: J Neurosci Res Volume: 91 Issue: 6 Pages: 737-744
  • DOI: 10.1002/jnr.23209
  • Peer Reviewed
• [Journal Article] Chronic degeneration of dorsal raphe serotonergic neurons modulates cortical spreading depression: A possible pathophysiology of migraine. (2013)
  • Author(s): Cui, Y.L., Li, Q.H., Yamada, H., Watanabe, Y., Kataoka, Y.
  • Journal Title: J Neurosci Res. Volume: 91 Pages: 737-744
  • Peer Reviewed
• [Journal Article] Functional anatomy of gustation in the alert rat revealed by positron emission tomography. (2013)
  • Author(s): Kobayashi, M., Cui, Y.L.., Sako, T., Sasabe, T., Mizoguchi, N., Wada, Y., Kataoka, Y., Koshikawa, N.
  • Journal Title: J Neurosci Res Volume: 91 Pages: 1363-1370
  • Peer Reviewed
• [Presentation] MicroPETを用いた急性および慢性疼痛モデルラットにおける疼痛認知・伝達回路の解析 (2013)
  • Author(s): 崔翼龍, 佐古健生, 豊田浩士, 林中恵美, 和田康弘, 渡辺恭良, 片岡洋祐
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都日本
  • Year and Date: 2013-06-21
• [Presentation] 片頭痛モデル動物を用いたオピオイド受容体のPETイメージング (2013)
  • Author(s): 崔翼龍、長田浩子、佐古健生、林中恵美、和田康弘、土居久志、渡辺恭良
  • Organizer: 第8回日本分子イメージング学会
  • Place of Presentation: 横浜
  • Year and Date: 2013-05-30
• [Presentation] Positron Emission Tomography (PET)による経鼻吸収評価系の確立 (2013)
  • Author(s): 新垣友隆、片山由美子、岡内隆、林中恵美、和田康弘、古林呂之、坂根稔康、崔翼龍、渡辺恭良
  • Organizer: 第8回日本分子イメージング学会
  • Place of Presentation: 横浜
  • Year and Date: 2013-05-30
• [Presentation] Positron Emission Tomography (PET) Imaging Analysis for Investigating Gastrointestinal Movement and Exploring Antiemetic Reagent under Treatment of Osteoporosis Reagent Teriparatide (2013)
  • Author(s): Shingaki, T., Katayama, Y., Okauchi, T., Hayashinaka, E., Wada, Y., Kato, N., Kuroda, T., Cui, Y.L., Watanabe Y
  • Organizer: 2013 American Association of Pharmaceutical Scientists Annual Meeting
  • Place of Presentation: San Antonio, USA
• [Presentation] MicroPETを用いた急性および慢性疼痛モデルラットにおける疼痛認知・伝達回路の解析 (2013)
  • Author(s): 崔 翼龍 佐古 健生 豊田 浩士 林中 恵美 和田 康弘 渡辺 恭良 片岡 洋祐
  • Organizer: 日本神経科学学会
  • Place of Presentation: 国立京都国際会館
• [Presentation] MicroPETを用いた急性および慢性疼痛モデルラットにおける疼痛認知・伝達回路の解析 (2013)
  • Author(s): 崔 翼龍 佐古 健生 豊田 浩士 林中 恵美 和田 康弘 渡辺 恭良 片岡 洋祐
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都
• [Presentation] 放射性ソマトスタチンアナログを用いた2型糖尿病モデルラットの膵内分泌細胞PETイメージング (2012)
  • Author(s): 佐古健生、長谷川功紀、崔翼龍、和田康弘、林中恵美、片岡洋祐、千田道雄、渡辺恭良
  • Organizer: 第52回日本核医学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-10-10
• [Presentation] MicroPETを用いた神経因性疼痛モデルラットの脳内疼痛認知・伝達回路の解析 (2012)
  • Author(s): 崔翼龍, 佐古健生, 奥山香里, 豊田浩士, 林中恵美, 和田康弘, 渡辺恭良, 片岡洋祐
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-19