Establishment of the molecule mechanism on the suppression of metastasis by radiation
Project/Area Number |
24659577
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Single-year Grants |
Research Field |
Radiation science
|
Research Institution | Tokyo Medical University |
Principal Investigator |
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 放射線 / 転移関連遺伝子 / 小胞体ストレス / シノビオリン / ヒストン修飾 / MMP2 / MMP9 |
Research Abstract |
Tumor has both genetic and epigenetic abnormality, i.e. individuality. Therefore, tumor shows various sensitivity or resistance to radiation. However, research on radiation-sensitivity/resistance from a viewpoint of epigenetics is not enough. In this study, we investigated molecular mechanism of response to irradiation of metastasis-associated genes and ER stress-associated genes
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Report
(3 results)
Research Products
(4 results)