Development of contrast agent of ultrasonography for visualizing pancreatic islets
Project/Area Number |
24659582
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
General surgery
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Research Institution | Tohoku University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KODAMA Tetsuya 東北大学, 医工学研究科, 教授 (40271986)
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 超音波検査 / ナノバブル / 膵島移植 / 超音波 / マイクロバブル |
Research Abstract |
In this study, we attempted to develop a novel contrast agent of ultrasonography aiming to visualizing transplanted pancreatic islets. The contrast agent was made by attachment of octreotide on liposome via polyethylene glycol chain, and was used after infusion of C3F8 gas. Enhanced ultrasonography using this agent for diabetic transplanted syngenetic islets showed increase of echogenicity in transplanted islets. The enhancement was significantly correlated with endocrine function of the mice.
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Report
(3 results)
Research Products
(63 results)
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[Journal Article] Clinical experiences in the treatment of pancreatic arteriovenous malformation by total pancreatectomy with islet autotransplantation2013
Author(s)
Sakata N, Goto M, Motoi F, Hayashi H, Nakagawa K, Mizuma M, Yamaya H, Hasegawa Y, Yamaguchi S, Sawada S, Ottomo S, Okada T, Fukase K, Yoshida H, Ito T, Hirota M, Ishigaki Y, Sekiguchi S, Rikiyama T, Katayose Y, Fujimori K, Egawa S, Shimosegawa T, Katagiri H, Satomi S, Unno M
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Journal Title
Transplantation
Volume: 96(5)
Related Report
Peer Reviewed
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[Journal Article] Postoperative cholestasis and cholangitis after total pancreatectomy with biliary reconstruction impair the function of autotransplanted islets2013
Author(s)
Hata T, Sakata N, Aoki T, Yoshimatsu G, Tsuchiya H, Hayashi H, Motoi F, Goto M, Katayose Y, Egawa S, Unno M
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Journal Title
Transplantation
Volume: 96(5)
Related Report
Peer Reviewed
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[Journal Article] Imaging of transplanted islets by positron emission tomography, magnetic resonance imaging, and ultrasonography2013
Author(s)
Sakata N, Yoshimatsu G, Tsuchiya H, Aoki T, Mizuma M, Motoi F, Katayose Y, Kodama T, Egawa S, Unno M
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Journal Title
Islets
Volume: 5(5)
Pages: 179-187
Related Report
Peer Reviewed
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[Journal Article] Clinical Experiences in the Treatment of Pancreatic Arteriovenous Malformation by Total Pancreatectomy With Islet Autotransplantation.2013
Author(s)
Sakata N, Goto M, Motoi F, Hayashi H, Nakagawa K, Mizuma M, Yamaya H, Hasegawa Y, Yamaguchi S, Sawada S, Ottomo S, Okada T, Fukase K, Yoshida H, Ito T, Hirota M, Ishigaki Y, Sekiguchi S, Rikiyama T, Katayose Y, Fujimori K, Egawa S, Shimosegawa T, Katagiri H, Satomi S, Unno M
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Journal Title
Transplantation
Volume: 96(5)
Issue: 5
Pages: e38-e40
DOI
Related Report
Peer Reviewed
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[Journal Article] Postoperative Cholestasis and Cholangitis after Total Pancreatectomy with Biliary Reconstruction Impair the Function of Autotransplanted islets2013
Author(s)
Hata T, Sakata N, Aoki T, Y oshimatsu G, T suchiya H, Hayashi H, Motoi F, Goto M, Katayose Y, Egawa S, Unno M
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Journal Title
Transplantation
Volume: 96(5)
Issue: 5
Pages: e40-e43
DOI
Related Report
Peer Reviewed
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[Journal Article] Imaging of transplanted islets by positron emission tomography, magnetic resonance imaging, and ultrasonography.2013
Author(s)
Sakata N, Yoshimatsu G, Tsuchiya H, Aoki T, Mizuma M, Motoi F, Katayose Y, Kodama T, Egawa S, Unno M.
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Journal Title
Islets
Volume: 5
Pages: 179-187
Related Report
Peer Reviewed
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[Presentation] Postoperative cholangitis and liver dysfunction after total pancreatectomy with biliary reconstruction impair the function of autotransplanted islets2013
Author(s)
Hata T, Sakata N, Aoki T, Yoshimatsu G, Tsuchiya H, Hayashi H, Motoi F, Goto M, Katayose Y, Egawa S, Unno M
Organizer
The 14^<th> World Congress of the International Pancreas and Islet Transplant Association (IPITA2013)
Place of Presentation
Monterey, USA
Related Report
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[Presentation] 膵島移植における安全かつ有効な移植部位の検討2013
Author(s)
土屋朗之、坂田直昭,吉松軍平,青木豪,水間正道,深瀬耕二,乙供 茂,大塚英郎,森川孝則,林 洋毅,中川 圭 ,岡田恭穂,吉田 寛,元井冬彦,内藤 剛,三浦 康,片寄 友,柴田 近,海野倫明
Organizer
第113回日本外科学会定期学術集会
Place of Presentation
福岡
Related Report
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[Presentation] Postoperative cholangitis and liver dysfunction after total pancreatectomy with biliary reconstruction impair the function of autotransplanted islets2013
Author(s)
Hata T, Sakata N, Aoki T, Yoshimatsu G, Tsuchiya H, Hayashi H, Motoi F, Goto M, Katayose Y, Egawa S, Unno M
Organizer
the 14th World Congress of the International Pancreas and Islet Transplant Association (IPITA 2013)
Place of Presentation
Monterey, USA
Related Report
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[Presentation] Surgical treatment for chronic pancreatitis, discussion of drainage and total pancreatectomy with islet autotransplantation2012
Author(s)
Sakata N, Yoshimatsu G, Aoki T, Ishida M, Fukase K, Ottomo S, Mizuma M, Okada T, Nakagawa K, Hayashi H, Morikawa T, Yoshida H, Motoi F, Naitoh T, Katayose Y, Miura K, Egawa S, Unno M
Organizer
2012 Joint American Pancreatic Association (APA) / International Association of Pancreatology (IAP) Annual Meeting
Place of Presentation
Miami, USA
Related Report
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[Presentation] 膵動静脈奇形に対する新たな治療戦略2012
Author(s)
坂田直昭,後藤昌史, 元井冬彦, 林 洋毅, 中川 圭, 水間正道, 山谷英之, 長谷川豊, 澤田正二郎, 吉松軍平, 伊藤経夫, 菅野 敦, 廣田衛久, 石垣 泰, 力山敏樹, 江川新一,他
Organizer
JDDW2012
Place of Presentation
神戸
Related Report
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[Presentation] Surgical treatment for chronic pancreatitis, discussion of drainage and total pancreatectomy with islet autotransplantation.2012
Author(s)
Sakata N, Yoshimatsu G, Aoki T, Ishida M, Fukase K, Ottomo S, Mizuma M, Okada T, Nakagawa K, Hayashi H, Morikawa T, Yoshida H, Motoi F, Naitoh T, Katayose Y, Miura K, Egawa S, Unno M
Organizer
2012 Joint American Pancreatic Association (APA) / International Association of Pancreatology (IAP) Annual Meeting
Place of Presentation
Miami, USA
Related Report
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