New strategy using diabetes therapeutic drug for the patients with vascular disease
| Project/Area Number |
24659586
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
KOMORI KIMIHIRO 名古屋大学, 医学(系)研究科(研究院), 教授 (40225587)
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| Co-Investigator(Kenkyū-buntansha) |
NARITA Hiroshi 名古屋大学, 医学部附属病院, 助教 (00528739)
KODAMA Akio 名古屋大学, 医学部附属病院, 病院助教 (10528748)
SUGIMOTO Masayuki 名古屋大学, 医学部附属病院, 病院助教 (00447814)
坂野 比呂志 名古屋大学, 医学部附属病院, 助教 (80584721)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 血管外科学 / 末梢動脈閉塞症 / 静脈グラフト血管内膜肥厚 / 重症虚血肢 / 動脈瘤 |
|---|
| Research Abstract |
(Background) We investigated whether metformin modulates the revascularization processes in vivo employing a hindlimb model of ischemia-induced angiogenesis. (Methods)Wild-type (WT) mice or eNOS deficient (eNOS-KO) mice were randomly divided into two groups. Mice were treated with or without metformine and were subjected to unilateral hind limb ischemia.(Results)WT mice (metformin group) showed accelerated limb perfusion following hindlimb ischemic surgery based upon laser Doppler measurements of blood flow and increased capillary density in ischemic muscle compared to non-treated mice. Metformin group significantly enhanced ischemia-induced increase in AMPK and eNOS phosphorylation levels in WT mice. In eNOS-KO mice, metformin significantly increased the phosphorylation of AMPK in ischemic tissue, but did not affect blood flow recovery in ischemic limb. (Conclusions)Metformin could promote revascularization in response to tissue ischemia via an AMPK/eNOS-dependent mechanism.
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Report
(3 results)
Research Products
(53 results)
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[Journal Article] Subclavian artery aneurysm in Marfan’s syndrome: Report of a case and review of literature.2014
Author(s)
Morisaki K, Kobayashi M, Miyachi H, Maekawa T, Tamai H , Takahashi N, Watanabe Y, Morimae H, Ihara T, Kodama A, Narita H, Banno H, Yamamoto K, Komori K
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Journal Title
Annals of Vasc Surg
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Post Stress Perfusion Abnormalities Detected by Myocardial Perfusion S PECT Predict Long-Term Mortality af ter Elective Abdominal Aortic Aneur ysm Repair2013
Author(s)
Inoue Y, Yoshikawa D, Ishii H, Isob e S, Kumagai S, Suzuki S, Okumura S ,Hayashi M, Matsubara T, Ohshima S, Banno H, Komori K, Kato K, Murohar a T
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Journal Title
Circulation Journal
Volume: 77(5)
Pages: 1229-34
Related Report
Peer Reviewed
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[Presentation] 静脈血栓塞栓症2013
Author(s)
古森公浩
Organizer
第75回日本臨床外科学会総会
Place of Presentation
名古屋国際会議場、名古屋市
Year and Date
2013-11-21
Related Report
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[Presentation] 末梢動脈疾患の診療2013
Author(s)
古森公浩
Organizer
第4回脈管専門医教育セッション
Place of Presentation
ステーションコンファレンス東京、東京都千代田区
Year and Date
2013-10-11
Related Report
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