The research of mechanisms between shear stress and caveola in the liver regeneration and liver injury

• Project/Area Number: 24659601
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: Showa University
• Principal Investigator: SATO Yoshinobu 昭和大学, 医学部, 講師 (20313538)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 肝再生 / 癌化 / 転移 / ずり応力 / caveolin-1 / PAI-1 / 脂肪肝 / カベオラ / shear stress / 癌増殖転移 / 上皮間葉転換 / 炎症 / 細胞マトリックス / 癌増殖 / 免疫

Research Abstract

Last year, I changed my work location from Niigata Univ. to Showa Univ. Therefore, I could not perform the scheduled program. We intended to investigate comprehensively about a role of Caveolin-1 and PAI-1 in the liver. The clinicopathological analyses were made in the regenerative liver, steatotic liver, metastatic liver, and primary hepatocellular carcinoma and the mechanisms of regeneration, carcinogenesis, inflammation, and cancer metastasis were studied. Pilot study by immunological staining of the metastatic liver of colon cancer with caveolin-1, PAI-1, MT1-MMP, CD44 were performed. I could recognize the interesting findings that both the specimen of metastatic liver and primary colon cancer in Type 5 of colon cancer revealed the augmentation of PAI-1 staining.

Research Products

• [Journal Article] Laparoscope-assisted Hassab's Operation for Esophagogastric Varices After Living Donor Liver Transplantation : A Case Report (2014)
  • Author(s): T. Kobayashi, K. Miura, H. Ishikawa, H. Oya, Y. Sato, et al
  • Journal Title: Transplantation Proceedings Volume: 46 Pages: 986-988
• [Journal Article] Increased activated natural killer T cells in the liver of patients with advancedstage primary biliary cirrhosis (2014)
  • Author(s): Aso-Ishimoto Y, Yamagiwa S, Ichida T, Miyakawa R, Tomiyama C, Sato Y, Watanabe H, Aoyagi Y
  • Journal Title: Biomed Volume: Res 35 Pages: 161-169
  • NAID: 130004470862
• [Journal Article] Successful laparoscopic division of patent ductus venosus : Report of a Case (2013)
  • Author(s): Yoshiaki Hara, Yoshinobu Sato, Satoshi Yamamoto, et al
  • Journal Title: Surgery Today Volume: 43 Pages: 434-438
  • NAID: 10031168033
• [Journal Article] Heterotopic pancreas autotransplantation with spleen for uncontrollable hemorrhagic pseudocyst and disabling pain in chronic pancreatitis (2013)
  • Author(s): Yoshinobu Sato, Hiroshi Oya, Satoshi Yamamoto, et al
  • Journal Title: Hepatogastroenterol Volume: 60 Pages: 425-427
• [Journal Article] Perioperative immunological differentiation in liver cirrhotic patients who underwent living related liver transplantation (2013)
  • Author(s): Sato Y, Tomiyama C, Yamamoto S, et al
  • Journal Title: Hepatogastroenterol Volume: 60 Pages: 666-668
• [Journal Article] Perioperative immunological differentiation in liver cirrhotic patients who underwent living related liver transplantation. (2013)
  • Author(s): ato Y*, Tomiyama C, Yamamoto S, Oya H, Kobayashi T, Kokai H, Miura K, Hirose Y, Hatakeyama K
  • Journal Title: Hepatogastroenterology Volume: 60 Pages: 666-668
  • Peer Reviewed
• [Journal Article] Heterotopic pancreas autotransplantation with spleen for uncontrollable hemorrhagic pseudocyst and disabling pain in chronic pancreatitis. (2013)
  • Author(s): Sato Y*, Oya H, Yamamoto S, Kokai H, Miura K, Hatakeyama K.
  • Journal Title: Hepatogastroenterology Volume: 60 Pages: 425-427
  • Peer Reviewed
• [Journal Article] Successful laparoscopic division of patent ductus venosus: Report of a Case. (2013)
  • Author(s): Yoshiaki Hara, Yoshinobu Sato*, Satoshi Yamamoto, Hiroshi Oya, Masato Igarashi, Satoshi Abe, Hironaka Kokai, Kohei Miura, Takeshi Suda, Minoru Nomoto, Yutaka Aoyagi, Katsuyoshi Hatakeyama.
  • Journal Title: Surgery Today Volume: 43 Pages: 434-438
  • NAID: 10031168033
  • Peer Reviewed
• [Journal Article] Catheter-directed continuous thrombolysis following aspiration thrombectomy via the ileocolic route for acute portal venous thrombosis: report of two cases. (2013)
  • Author(s): Miura K, Sato Y*, Nakatsuka H, Yamamoto S, Oya H, Hara Y, Kokai H, Hatakeyama K.
  • Journal Title: Surgery Today Volume: 43 Pages: 1310-1315
  • Peer Reviewed