| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Last year, I changed my work location from Niigata Univ. to Showa Univ. Therefore, I could not perform the scheduled program. We intended to investigate comprehensively about a role of Caveolin-1 and PAI-1 in the liver. The clinicopathological analyses were made in the regenerative liver, steatotic liver, metastatic liver, and primary hepatocellular carcinoma and the mechanisms of regeneration, carcinogenesis, inflammation, and cancer metastasis were studied. Pilot study by immunological staining of the metastatic liver of colon cancer with caveolin-1, PAI-1, MT1-MMP, CD44 were performed. I could recognize the interesting findings that both the specimen of metastatic liver and primary colon cancer in Type 5 of colon cancer revealed the augmentation of PAI-1 staining.
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