| Project/Area Number |
24659604
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
NAGINO Masato 名古屋大学, 医学(系)研究科(研究院), 教授 (20237564)
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| Co-Investigator(Kenkyū-buntansha) |
YOKOYAMA Yukihiro 名古屋大学, 医学部附属病院, 講師 (80378091)
KOKURYO Toshio 名古屋大学, 医学系研究科, 特任講師 (60378023)
IGAMI Tuyoshi 名古屋大学, 医学部附属病院, 病院講師 (50420378)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 肝虚血・再灌流 / 一酸化窒素 / 肝障害 / 肝虚血・再潅流 |
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| Outline of Final Research Achievements |
We developed the NO sensor as a real-time monitoring system for the liver function. Intrahepatic NO levels increased and then reached a plateau approximately 15 min after starting ischemia during I/R (ischemia/reperfusion). The sinusoids after 5 min reperfusion were dilated compared with the sinusoids before ischemia during I/R. The phospho-eNOS expression increased during the first ischemia, and then the levels decreased during the subsequent repeating I/R; however, the iNOS expression gradually increased.
This study revealed an altered activation of the phospho-eNOS and iNOS over the course of repeated I/R.
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