| Project/Area Number |
24659605
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
HATANO Etsuro 京都大学, 医学(系)研究科(研究院), 講師 (80359801)
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| Co-Investigator(Kenkyū-buntansha) |
UEMOTO Shinji 京都大学, 医学研究科, 教授 (40252449)
TAURA Kojiro 京都大学, 医学研究科, 助教 (80378629)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 肝切除 / 肝不全 / ARFI / 肝線維化 / 肝切除後肝不全 / liver stiffness |
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| Research Abstract |
We aimed to assess the usefulness of liver stiffness measurement based on Acoustic Radiation Force Impulse (ARFI) for the prediction of posthepatectomy liver failure (PHLF) by prospectively analyzing clinical data of 200 patients who underwent hepatic resection. Univariate analysis revealed that liver stiffness value measured by ARFI was one of the most efficient markers in predicting PHLF as well as an excellent indicator of the grade of pathological liver fibrosis. To improve the predictive accuracy, we further performed multivariate analysis and established a novel formula that quantitatively estimates the risk of PHLF by combination of 4 significant factors: liver stiffness, platelet count, total bilirubin, and remnant liver volume rate. The validity of the formula was verified, suggesting it could be applied to clinical use in the future.
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