Comprehensive metabolome analysis of pancreatic cancer for identifying the pancreatic cancer-specific metabolic traits
| Project/Area Number |
24659612
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
YACHIDA Shinichi 独立行政法人国立がん研究センター, 研究所, ユニット長 (20359920)
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| Co-Investigator(Kenkyū-buntansha) |
岡野 圭一 香川大学, 医学部附属病院, 准教授 (20314916)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 膵臓癌 / メタボローム / メタボローム解析 / 膵癌 |
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| Research Abstract |
The pancreatic cancer is a devastating disease. We have performed the comprehensive metabolome analysis method based on capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS), which allows quantitative analysis of thousands of charged metabolites. This approach was applied to simultaneous analysis of metabolite levels in tumor and normal counterparts obtained from 24 patients with pancreatic cancer. Enhanced glycolysis was found in tumor tissues, indicating the Warburg effect, which is the enhanced conversion of glucose to lactate observed in tumor cells, even in the presence of normal levels of oxygen. In addition, quantification of hundred metabolites resulted in the identification of pancreatic cancer-specific metabolic traits. The amino acid concentrations were increased in tumor tissues. These data will apply into advanced imaging methods and blood tests to detect pancreatic cancer-specific metabolomes, which offer hope for such non-invasive early detection
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] Heterogeneity of pancreatic cancer metastases in a single patient revealed by quantitative proteomics2014
Author(s)
Kim MS, Zhong Y, Yachida S, Rajeshkumar NV, Abel ML, Marimuthu A, Mudgal K, Hruban RH, Poling JS, Tyner JW, Maitra A, Iacobuzio-Donahue CA, Pandey A
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Journal Title
Mol Cell Proteomics
Volume: (in press)(pii : mcp.M114.038547)
Related Report
Peer Reviewed
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[Journal Article] Clinical significance of the genetic landscape of pancreatic cancer and implications for identification of potential long-term survivors2012
Author(s)
Yachida S, White CM, Naito Y, Zhong Y, Brosnan JA, Macgregor-Das AM, Morgan RA, Saunders T, Laheru DA, Herman JM, Hruban RH, Klein AP, Jones S, V elculescu V, Wolfganag CL, Iacobuzio-Donahue CA
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Journal Title
Clin Cancer Res
Volume: 18
Issue: 22
Pages: 6339-47
DOI
Related Report
Peer Reviewed
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