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Comprehensive metabolome analysis of pancreatic cancer for identifying the pancreatic cancer-specific metabolic traits

Research Project

Project/Area Number 24659612
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

YACHIDA Shinichi  独立行政法人国立がん研究センター, 研究所, ユニット長 (20359920)

Co-Investigator(Kenkyū-buntansha) 岡野 圭一  香川大学, 医学部附属病院, 准教授 (20314916)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords膵臓癌 / メタボローム / メタボローム解析 / 膵癌
Research Abstract

The pancreatic cancer is a devastating disease. We have performed the comprehensive metabolome analysis method based on capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS), which allows quantitative analysis of thousands of charged metabolites. This approach was applied to simultaneous analysis of metabolite levels in tumor and normal counterparts obtained from 24 patients with pancreatic cancer. Enhanced glycolysis was found in tumor tissues, indicating the Warburg effect, which is the enhanced conversion of glucose to lactate observed in tumor cells, even in the presence of normal levels of oxygen. In addition, quantification of hundred metabolites resulted in the identification of pancreatic cancer-specific metabolic traits. The amino acid concentrations were increased in tumor tissues. These data will apply into advanced imaging methods and blood tests to detect pancreatic cancer-specific metabolomes, which offer hope for such non-invasive early detection

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (9 results)

All 2014 2013 2012

All Journal Article (9 results) (of which Peer Reviewed: 9 results)

  • [Journal Article] Heterogeneity of pancreatic cancer metastases in a single patient revealed by quantitative proteomics2014

    • Author(s)
      Kim MS, Zhong Y, Yachida S, Rajeshkumar NV, Abel ML, Marimuthu A, Mudgal K, Hruban RH, Poling JS, Tyner JW, Maitra A, Iacobuzio-Donahue CA, Pandey A
    • Journal Title

      Mol Cell Proteomics

      Volume: (in press)(pii : mcp.M114.038547)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemically detected expression of three major genes (CDKN2A/p16, TP53 and SMAD4/DPC4) strongly predicts survival in patients with pancreatic cancer2013

    • Author(s)
      Oshima M, Okano K, Muraki S, Haba R, Maeba T, Suzuki Y, Yachida S
    • Journal Title

      Ann Surg

      Volume: 258 Pages: 336-346

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article]2013

    • Author(s)
      Yachida S, Iacobuzio-Donahue CA
    • Journal Title

      Oncogene

      Volume: 32 Issue: 45 Pages: 5253-5260

    • DOI

      10.1038/onc.2013.29

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathology of recurrent hepatocellular carcinomas after radiofrequency ablation treated with salvage surgery2013

    • Author(s)
      Yamamoto N, Okano K, Kushida Y, Deguchi A, Yachida S, Suzuki Y
    • Journal Title

      Hepatol Res

      Volume: in press Issue: 11 Pages: 1062-1071

    • DOI

      10.1111/hepr.12223

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemically detected expression of 3 major genes (CDKN2A/p16, TP53, and SMAD4/DPC4) strongly predicts survival in patients with resectable pancreatic cancer2013

    • Author(s)
      Minoru Oshima, Keiichi Okano, Shinobu Muraki, Reiji Haba, Takashi Maeba, Yasuyuki Maeba, Shinichi Yachida
    • Journal Title

      Annals of Surgery

      Volume: 258 Issue: 2 Pages: 336-346

    • DOI

      10.1097/sla.0b013e3182827a65

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of the genetic landscape of pancreatic cancer and implications for identification of potential long-term survivors2012

    • Author(s)
      Yachida S, White CM, Naito Y, Zhong Y, Brosnan JA, Macgregor-Das AM, Morgan RA, Saunders T, Laheru DA, Herman JM, Hruban RH, Klein AP, Jones S, V elculescu V, Wolfganag CL, Iacobuzio-Donahue CA
    • Journal Title

      Clin Cancer Res

      Volume: 18 Issue: 22 Pages: 6339-47

    • DOI

      10.1158/1078-0432.ccr-12-1215

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Novel therapeutic approaches in pancreatic cancer based on genomic alterations2012

    • Author(s)
      Yachida S
    • Journal Title

      Curr Pharm Des

      Volume: 18 Pages: 2452-63

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel therapeutic approaches in pancreatic cancer based on genomic alterations2012

    • Author(s)
      Shinichi Yachida
    • Journal Title

      Current Pharmaceutical Design

      Volume: 18 Pages: 2452-2463

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Small cell and large cell neuroendocrine carcinomas of the pancreas are genetically similar and distinct from well-differentiated pancreatic neuroendocrine tumors2012

    • Author(s)
      Shinichi Yachida
    • Journal Title

      Americal Journal od Surgical Pathology

      Volume: 36 Issue: 2 Pages: 173-184

    • DOI

      10.1097/pas.0b013e3182417d36

    • Related Report
      2012 Research-status Report
    • Peer Reviewed

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Published: 2013-05-31   Modified: 2019-07-29  

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