| Project/Area Number |
24659619
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Fukushima Medical University |
|---|
Principal Investigator |
NAKAMURA IZUMI 福島県立医科大学, 医学部, 准教授 (80423804)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OHKI Shinji 福島県立医科大学, 器官制御外科, 准教授 (20381361)
TAKENOSHITA Seiichi 福島県立医科大学, 器官制御外科, 教授 (10167489)
齋藤 元伸 福島県立医科大学, 医学部, 研究員 (90611749)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
|---|
| Keywords | MSI / 大腸癌 / miRNA |
|---|
| Outline of Final Research Achievements |
Mismatch repair-deficient colorectal cancers display widespread instability at DNA microsatellite sequences (MSI). But MSI has been reported to commonly occur at coding repeats, leading to alterations in the function of a number of genes encoding cancer-related proteins, nothing is known about the putative impact of this process on non-coding microRNAs.
We considered whether genetic mutation due to MSI changed the structure of miRNA hairpin loop by using thermodynamic free energy.Our results provide evidence that DNA repeats contained in human miRNA gene are relatively rare and preserved from mutations due to MSI.
|
