| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
Based on the gene expression of colorectal cancers, we aimed to build a predictive model for response to chemotherapy based on molecular target agent (bevacizumab). Using 41 samples, we examined gene expression by microarray, then validated them by RT-PCR method. We finally selected 3- and 2-gene sets and made 2-gene and 3-gene predictive models. The accuracy rate of prediction was 73.2 %(3-gene model) and 75.6%(2-gene model). We also examined the correlations of these genes with individual drug responses on tumor cell lines deposited on public database.
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