| Project/Area Number |
24659624
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SADO Tetsu 東北大学, 大学病院, 助教 (20396485)
OKADA Yoshinori 東北大学, 加齢医学研究所, 准教授 (90323104)
KONDO Takashi 東北大学, 加齢医学研究所, 教授 (10195901)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 肺移植 / ドナー / 脳死 / 肺胞上皮 / ナトリウムチャネル / 急性拒絶反応 / 肺胞水分クリアランス / sodium channel / 肺胞水分吸収 / イオンチャンネル / マイクロサンプリング |
|---|
| Research Abstract |
Acute rejection after lung transplantation is lethal.We discovered a significant decrease in alveolar fluid clearance at 72hrs after animal lung transplantaion by acute rejection models. On the other hand discovered a no significant change in alveolar fluid clearance at 72hrs after animal lung transplantaion by non-acute rejection models. Monitoring of alveolar epithelial function after lung transplantaion is useful for detection by acute rejection.
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