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Development of novel vascular anastomosis device with biodegradable stent

Research Project

Project/Area Number 24659627
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionMie University

Principal Investigator

MUTO Akihito  三重大学, 医学(系)研究科(研究院), 助教 (30600829)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords血管外科学 / 生体材料 / 血管外科
Research Abstract

In this study, we developed the novel technique of vascular anastomosis for severe atherosclerosis patient that had difficulty in manual direct vascular suture technique. We examined to use bioabsorbable reinforcement material and cyanoacrylate.
In ex vivo study with porcine carotid artery, we confirmed better strength of biodegradable stent and bioglue method compare to conventional direct vascular suture method in both of the mechanical extension test and the water burst pressure test. On the other hand, we could not avoid acute thrombotic occlusion in vivo study with canine model. We think that we can expect for future clinical application by solving this thrombosis problem.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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