|Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
In this study, we developed the novel technique of vascular anastomosis for severe atherosclerosis patient that had difficulty in manual direct vascular suture technique. We examined to use bioabsorbable reinforcement material and cyanoacrylate.
In ex vivo study with porcine carotid artery, we confirmed better strength of biodegradable stent and bioglue method compare to conventional direct vascular suture method in both of the mechanical extension test and the water burst pressure test. On the other hand, we could not avoid acute thrombotic occlusion in vivo study with canine model. We think that we can expect for future clinical application by solving this thrombosis problem.