| Project/Area Number |
24659629
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Thoracic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
MEINOSHIN Okumura 大阪大学, 医学(系)研究科(研究院), 教授 (40252647)
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| Co-Investigator(Kenkyū-buntansha) |
MINAMI Masato 大阪大学, 医学部附属病院, 准教授 (10240847)
INOUE Masayoshi 大阪大学, 医学系研究科, 准教授 (10379232)
SAWABATA Noriyoshi 大阪大学, 医学系研究科, 准教授 (50403184)
NAKAGIRI Tomoyuki 大阪大学, 医学系研究科, 招へい教員 (70528710)
SHINTANI Yasushi 大阪大学, 医学系研究科, 講師 (90572983)
KAWAMURA Tomohiro 大阪大学, 医学系研究科, 助教 (30528675)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 肺再生医療 / 閉塞性肺疾患 / アディポネクチン / PGI2アナログ / 肺再生 / 脂肪細胞 / 脂肪幹細胞 / プロスタグランディンI2 / 肺移植 / 拒絶反応 / 免疫抑制 / IL-6 amplifier / EGF / 再生医療 / 肺気腫 / 重症呼吸不全 / 細胞治療 |
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| Outline of Final Research Achievements |
COPD is a major cause of chronic morbidity and mortality worldwide, and there is a need to develop more effective therapeutic strategies to replace specialized treatment such as lung transplantation. Adiponectin (APN) is a unique adipokine with multiple salutary effects such as antiapoptotic, anti-inflammatory, and anti-oxidative activities in numerous organs and cells and mice lacking APN spontaneously develop a COPD-like phenotype with extrapulmonary effects. Transplanted adipose tissue from wild type mice sttenuated COPD-like chnages in mice lacking APN. ONO-1301 is a synthetic prostacyclin analog characterized by chemically stable structure and enhances the secretion of adypocyte derived APN. These data suggested that APN is an intriguing candidate as a promotive agent for compensatory lung regeneration in COPD patients and prostacyclin analog enhanced alveolar cell proliferation, and induce lung regeneration through APN.
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