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Pathogenesis of bleb formation in idiopathic pneumothorax

Research Project

Project/Area Number 24659636
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionSaga University

Principal Investigator

TAKEDA Yuji  佐賀大学, 医学部, 助教 (20530182)

Co-Investigator(Kenkyū-buntansha) AOKI Shigehisa  佐賀大学, 医学部, 准教授 (10448441)
SAKURAGI Toru  佐賀大学, 医学部, 講師 (20315188)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsブレブ形成 / 自然気胸 / 遺伝子解析 / ブレブ / ウィルス
Research Abstract

Purpose: The Bleb, which can cause spontaneous pneumothorax development. We conducted a study in order to identify the presence of a specific pathogen in the formation of the Bleb. Method: From the lungs excised during spontaneous pneumothorax surgery, by extracting RNA and DNA, was subjected to gene search using a sensitive exhaustive search method pathogens.
Result: Such as TTV, HHV-6, HHV-7, EBV, parvovirus B19 were detected from Bleb part. But these viruses are detected from the normal lung tissue, except parvovirus B19. Relevance of bleb formation and these pathogens unknown at this time. Conclusion: Identification of specific pathogens were unable to Bleb tissue that could be the pathogenesis of pneumothorax.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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