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Development of a heat-melting method for stent graft suturing

Research Project

Project/Area Number 24659638
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionYokohama City University

Principal Investigator

NOISHIKI Yasuharu  横浜市立大学, 医学(系)研究科(研究院), 客員教授 (60033263)

Co-Investigator(Renkei-kenkyūsha) ITO Hiroshi  横浜市立大学, 医学研究科, 客員教授 (80124303)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsステントグラフト / 触れ / 熱融着 / ポリエステル繊維 / 崇高 / 芯鞘構造 / 細径化 / 縫合糸 / ポリエステル
Research Abstract

Stent grafts have several problems which should be solved urgently. One of them is a fraying problem after suture ligation. Expandable metal wires are fixed by sutures with fabric grafts by sutures, which are made of polymer materials such as polyester fibers. As polymer materials are usually slippery, more than three-time ligations are required to prevent the knots become loose, which resulted in bulky. Generally bulky knots are not desirable for slim stent grafts. In order to solve the problem, we have developed a hybrid suture made of regular polyester fibers coated with special polymer having a lower melting point, around 180~220 Celsius,while regular polyester fibers melts at 260 Celsius. Using our special sutures, all the knots of ligated sites of the tested stent graft were fixed by meltdown of the polymer when the graft was heated at 220 Celsius. Consequently, the fraying problem is completely overcome after 220 Celsius heating of stent grafts.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (12 results)

All 2013 2012 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (8 results)

  • [Journal Article] Elevated microsatellite alterations at selected tetra-nucleotide (EMAST) in non-small cell lung cancers – a potential determinant of susceptibility to multiple malignancies2013

    • Author(s)
      H. Arai, K Okudera, H. Oshiro, N. Komitsu, H. Mitsui, T. Nishi, M. Tsuboi, A. Nozawa, Y. Noishiki, K. Ohhashi, K. Inui, M. Masuda
    • Journal Title

      Int. J. Clin. Exp Pathol

      Volume: 6(3) Pages: 395-410

    • URL

      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563186/

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Elevated microsatellite alterations at selected tetra-nucleotide (EMAST) in non-small cell lung cancers - a potential determinant of susceptibility to multiple malignancies2013

    • Author(s)
      H. Arai, K Okudera, H. Oshiro, N. Komitsu, H. Mitsui, T. Nishi, M. Tsuboi, A. Nozawa, Y. Noishiki, K. Ohhashi, K. Inui,M.Masuda
    • Journal Title

      Int. J. Clin. Exp Patho

      Volume: 6(3) Pages: 359-410

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevated microsatellite alterations at selected tetra-nucleotide (EMAST) in non-small cell lung cancers – a potential determinant of susceptibility to multiple malignancies.2013

    • Author(s)
      H. Arai, et al
    • Journal Title

      Int. J. Clin. Exp Patho

      Volume: 6(3) Pages: 359-410

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Plasmodium induced by SU6656, an Sre family kinase inhibitor, in accompanied by a contractile ring defect.2012

    • Author(s)
      K. Yoshida, et al
    • Journal Title

      Cell Biochem. Func

      Volume: 30(1) Pages: 33-40

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 遠隔期に非吻合部に発生する人工血管の新規合併症 : 過去の結合織管の実験結果からの発生機序に関する仮設2013

    • Author(s)
      冨澤康子、野一色泰晴、大越隆文
    • Organizer
      第51回日本人工臓器学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2013-09-27
    • Related Report
      2013 Final Research Report
  • [Presentation] 人工血管壁における再生内膜平滑筋細胞配列の走査電顕観察2013

    • Author(s)
      野一色泰晴、伊藤博、跡部好敏、船越健悟
    • Organizer
      第29回医学生物学電子顕微鏡技術学会
    • Place of Presentation
      神奈川歯科大学(神奈川県横須賀市)
    • Year and Date
      2013-06-09
    • Related Report
      2013 Final Research Report
  • [Presentation] 細胞の動きを止め、細胞成長因子を拡散させる機能を組み込んだ癒着防止膜2012

    • Author(s)
      野一色泰晴、伊藤博
    • Organizer
      第3回生体由来材料研究会
    • Place of Presentation
      大日精化工業(株)研修センター(東京)
    • Year and Date
      2012-12-10
    • Related Report
      2013 Final Research Report
  • [Presentation] 癒着防止膜の現状 水の動きと細胞の動き2012

    • Author(s)
      野一色泰晴、伊藤博
    • Organizer
      第2回バイオマテリアル基材研究会
    • Place of Presentation
      (株)ハイレックスコーポレーション会議室(兵庫県)
    • Year and Date
      2012-07-26
    • Related Report
      2013 Final Research Report
  • [Presentation] 癒着防止膜の現状。水の動きと細胞の動き2012

    • Author(s)
      野一色泰晴、伊藤博
    • Organizer
      第2回バイオマテリアル基材研究会
    • Place of Presentation
      (株)ハイレックスコーポレーション会議室(兵庫県)
    • Related Report
      2012 Research-status Report
  • [Presentation] 細胞の動きを止め、細胞成長因子を拡散させる機能を組み込んだ癒着防止膜2012

    • Author(s)
      野一色泰晴、伊藤博
    • Organizer
      第3回生体由来材料研究会
    • Place of Presentation
      大日精化工業(株)研修センター(東京都)
    • Related Report
      2012 Research-status Report
  • [Presentation] 遠隔期に非吻合部に発生する人工血管の新規合併症:過去の結合織管の実験結果からの発生機序に関する仮設

    • Author(s)
      冨澤康子、野一色泰晴、大越隆文
    • Organizer
      第51回日本人工臓器学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 人工血管壁における再生内膜平滑筋細胞配列の走査電顕観察

    • Author(s)
      野一色 泰晴、伊藤博、跡部好敏、船越健吾
    • Organizer
      第29回医学生物学電子顕微鏡技術学会
    • Place of Presentation
      神奈川歯科大学(神奈川県横須賀市)
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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