| Project/Area Number |
24659645
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Cerebral neurosurgery
|
|---|
| Research Institution | University of Tsukuba |
|---|
Principal Investigator |
TAKANO Shingo 筑波大学, 学内共同利用施設等, 病院講師 (50292553)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
UEBA Tetsuya 高知大学, 医学部, 教授 (00314203)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 血管新生 / 膠芽腫 / 合成ペプチド / FGF2 / FGF2受容体 / 脳梗塞 / アンチセンスホモロジーボックス / 血管内皮細胞 / グリオーマ / 血管新生抑制 / 内皮細胞 / 光線力学療法 / ペプチド療法 / アンチセンス・ホモロジーボックス / クラニアルウィンドウ / 管腔形成 / ホモロジーボックス / 組織因子 / endoglin / jagged-1 / VEGF |
|---|
| Outline of Final Research Achievements |
As a specific inhibitor for angiogenic factor FGF2, we are interested in antisence homology box (AHB) in FGF2 receptor. Based on the computer analysis of FGF2 receptor, 13 synthetic peptides for AHB were designed. Human endothelial cell proliferation assay was determined with these peptides. Unexpectedly, some peptides demonstrated strong endothelial proliferation activity with elevated FGF2 signal transduction. Finally the angiogenic activity of the peptide was confirmed by other several assays. We propose AHB derived FGF2 receptor peptide is a candidate of angiogenic therapy for ischemic disease such as cerebral infarction.
|
