| Project/Area Number |
24659646
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Gifu University |
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Principal Investigator |
IWAMA Toru 岐阜大学, 医学(系)研究科(研究院), 教授 (20303498)
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| Co-Investigator(Kenkyū-buntansha) |
YANO Hirohito 岐阜大学, 大学院医学系研究科, 准教授 (00332685)
OHE Naoyuki 岐阜大学, 医学部附属病院, 准教授 (60362159)
NAKAYAMA Noriyuki 岐阜大学, 医学部附属病院, 講師 (30444277)
ENOMOTO Yukiko 岐阜大学, 大学院医学系研究科, 助教 (20377659)
YOSHIMURA Shinichi 兵庫医科大学, 医学部, 教授 (40240353)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 主幹動脈狭窄症 / 炎症性サイトカイン / 動脈硬化進展作用 / 主幹動脈狭窄症炎症 |
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| Research Abstract |
This study revealed that shear-induced platelet-derived inflammatory cytokines, such as sCD40L, interleukins, increase in time-dependent manner. In carotid stenosis patients, a significant time-dependent increase of platelet-derived inflammatory cytokines was observed in the patients with diabetes compared to the patient without it. The clinical study for the patients with carotid artery stenosis to elucidate the correlation between cardiovascular events, plaque volume, and lipid ratio and inflammatory cytokines value revealed that the value of inflammatory cytokines are significantly high in the patients developed cerebrovascular event and the patients with vulnerable plaque. About its mechanism and its intracellular signal transduction are still under consideration. Some of these content has been already reported in journals(J Stroke Cerebrovasc Dis. 2012).
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