Mechanism of atherosclerosis progression by platelet-derived inflammatory cytokines in carotid artery stenosis

• Project/Area Number: 24659646
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Cerebral neurosurgery
• Research Institution: Gifu University
• Principal Investigator: IWAMA Toru 岐阜大学, 医学(系)研究科(研究院), 教授 (20303498)
• Co-Investigator(Kenkyū-buntansha): YANO Hirohito 岐阜大学, 大学院医学系研究科, 准教授 (00332685) ; OHE Naoyuki 岐阜大学, 医学部附属病院, 准教授 (60362159) ; NAKAYAMA Noriyuki 岐阜大学, 医学部附属病院, 講師 (30444277) ; ENOMOTO Yukiko 岐阜大学, 大学院医学系研究科, 助教 (20377659) ; YOSHIMURA Shinichi 兵庫医科大学, 医学部, 教授 (40240353)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 主幹動脈狭窄症 / 炎症性サイトカイン / 動脈硬化進展作用 / 主幹動脈狭窄症炎症

Research Abstract

This study revealed that shear-induced platelet-derived inflammatory cytokines, such as sCD40L, interleukins, increase in time-dependent manner. In carotid stenosis patients, a significant time-dependent increase of platelet-derived inflammatory cytokines was observed in the patients with diabetes compared to the patient without it. The clinical study for the patients with carotid artery stenosis to elucidate the correlation between cardiovascular events, plaque volume, and lipid ratio and inflammatory cytokines value revealed that the value of inflammatory cytokines are significantly high in the patients developed cerebrovascular event and the patients with vulnerable plaque. About its mechanism and its intracellular signal transduction are still under consideration. Some of these content has been already reported in journals(J Stroke Cerebrovasc Dis. 2012).

Research Products

• [Journal Article] Selection of carotid artery stenting or endarterectomy based on magnetic resonance plaque imaging reduced periprocedural adverse events (2013)
  • Author(s): Yoshimura S,Yamada K,Kawasaki M,Asano T,Kanematsu M,Miyai M,Enomoto Y,Egashira Y,Iwama T
  • Journal Title: J Stroke Cerebrovasc Dis Volume: 22 Pages: 1082-1087
  • Peer Reviewed
• [Journal Article] Silent coronary artery disease in Japanese patients undergoing carotid artery stenting (2013)
  • Author(s): Enomoto Y,Yoshimura S,Yamada K,Kawasaki M,Nishigaki K,Minatoguchi S,Iwama T
  • Journal Title: J Stroke Cerebrovasc Dis Volume: 22 Pages: 1163-8
  • Peer Reviewed
• [Journal Article] The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment. (2013)
  • Author(s): Egashira Y, Suzuki Y, Azuma Y, Takagi T, Mishiro K, Sugitani S, Tsuruma K, Shimazawa M, Yoshimura S, Kashimata M, Iwama T, Hara H
  • Journal Title: J Neuroinflammation Volume: 10 Pages: 105-105
  • DOI: 10.1186/1742-2094-10-105
  • Peer Reviewed
• [Journal Article] Selection of carotid artery stenting or endarterectomy based on magnetic resonance plaque imaging reduced periprocedural adverse events. (2013)
  • Author(s): Yoshimura S, Yamada K, Kawasaki M, Asano T, Kanematsu M, Miyai M, Enomoto Y, Egashira Y, Iwama T
  • Journal Title: J Stroke Cerebrovasc Dis Volume: 22 Pages: 1082-1087
  • Peer Reviewed
• [Journal Article] Silent coronary artery disease in Japanese patients undergoing carotid artery stenting. (2013)
  • Author(s): Enomoto Y, Yoshimura S, Yamada K, Kawasaki M, Nishigaki K, Minatoguchi S, Iwama T
  • Journal Title: J Stroke Cerebrovasc Dis Volume: 22 Pages: 1163-1168
  • Peer Reviewed
• [Journal Article] Visualization of internal carotid artery atherosclerotic plaques in symptomatic and asymptomatic patients : a comparison of optical coherence tomography and intravascular ultrasound (2012)
  • Author(s): Yoshimura S,Kawasaki M,Yamada K,Enomoto Y,Egashira Y,Hattori A,Nishigaki K,Minatoguchi S,Iwama T
  • Journal Title: AJNR Am J Neuroradiol Volume: 33 Pages: 308-13
  • DOI: 10.3174/ajnr.a2740
  • Peer Reviewed
• [Journal Article] 頚動脈ステント留置患者の抗血小板療法 (2012)
  • Author(s): 榎本由貴子,吉村紳一
  • Journal Title: Circulation Volume: 12 Pages: 44-51
  • Peer Reviewed
• [Journal Article] Selection of carotid artery stenting or endoarterectomy based on magnetic resonance plaque imaging reduced periprocedural adverse events. (2012)
  • Author(s): Yoshimura S
  • Journal Title: J Stroke Cerebrovasc Dis Volume: Aug 29
  • Peer Reviewed
• [Journal Article] 頸動脈ステント留置患者の抗血小板療法. (2012)
  • Author(s): 榎本由貴子
  • Journal Title: Circulation Volume: 12 Pages: 44-51
  • Peer Reviewed
• [Presentation] Long-term magnetic resonance angiography follow-up of recanalized vessels after mechanical clot extraction (2013)
  • Author(s): Enomoto Y,Yoshimura S,Egashira Y,Iwama T
  • Organizer: International stroke conference 2013
  • Place of Presentation: Honolulu
• [Presentation] The growth factor progranulin suppresses inflammatory reactions and attenuates neuronal injury induced by cerebral ischemia-reperfusion in mice (2013)
  • Author(s): Egashira Y,Sugitani S,Suzuki Y,Mishiro K,Tsuruma K,Shimazawa M,Yoshimura S,Iwama T,Hara H
  • Organizer: International stroke conference 2013
  • Place of Presentation: Honolulu
• [Presentation] Correlation between light transmission aggregometry and VerifyNow assay in the patients undergoing neuroendovascular therapy (2012)
  • Author(s): Enomoto Y,Yoshimura S,Iwama T
  • Organizer: 10th Meeting of Asian-Australasian federation of interventional and therapeutic neuroradiology
  • Place of Presentation: Nagoya(Free paper)
• [Presentation] Correlation between light transmission aggregometry and VerifyNow assay in the patients undergoing neuroendovascular therapy. (2012)
  • Author(s): Enomoto Y, Yoshimura S, Iwama T(Free paper)
  • Organizer: 10th Meeting of Asian-Australasian federation of interventional and therapeutic neuroradiology
  • Place of Presentation: Nagoya
• [Remarks]
  • URL: http://www.med.gifu-u.ac.jp/neurosurgery/
• [Remarks] 岐阜大学医学部脳神経外科
  • URL: http://www.med.gifu-u.ac.jp/neurosurgery/