Role of glial cells in cell transplantation therapy
| Project/Area Number |
24659649
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kyoto University |
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Principal Investigator |
MOTONO Makoto 京都大学, iPS細胞研究所, 特定研究員 (30619622)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 分化誘導 / トランスフォーミング増殖因子 / ドパミン神経 / 細胞移植 / TGF beta / ドパミン神経前駆細胞 / Nurr1 / グリア細胞 / 分泌因子 / ドパミン神経細胞 / 共培養 |
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| Outline of Final Research Achievements |
As a new treatment alternative to pharmaceutical therapy for Parkinson’s disease, we have been studying the development of cell transplantation therapy to compensate for the neurons lost by the disease. When the neurons were differentiated from embryonic or induced pluripotent stem cells, a factor, which is secreted from glial cells, was added to the differentiation medium that had been developed to date. In the result, the induced neurons were higher quality cells as ones in transplantation therapy than those induced in the previous method.
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Report
(4 results)
Research Products
(3 results)
