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Role of glial cells in cell transplantation therapy

Research Project

Project/Area Number 24659649
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Cerebral neurosurgery
Research InstitutionKyoto University

Principal Investigator

MOTONO Makoto  京都大学, iPS細胞研究所, 特定研究員 (30619622)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords分化誘導 / トランスフォーミング増殖因子 / ドパミン神経 / 細胞移植 / TGF beta / ドパミン神経前駆細胞 / Nurr1 / グリア細胞 / 分泌因子 / ドパミン神経細胞 / 共培養
Outline of Final Research Achievements

As a new treatment alternative to pharmaceutical therapy for Parkinson’s disease, we have been studying the development of cell transplantation therapy to compensate for the neurons lost by the disease. When the neurons were differentiated from embryonic or induced pluripotent stem cells, a factor, which is secreted from glial cells, was added to the differentiation medium that had been developed to date. In the result, the induced neurons were higher quality cells as ones in transplantation therapy than those induced in the previous method.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (3 results)

All 2015 Other

All Presentation (2 results) Remarks (1 results)

  • [Presentation] Relationship between NURR1 expression and developing dopaminergic progenitor cells2015

    • Author(s)
      Motono Makoto, Takahashi Jun
    • Organizer
      International Society for Stem Cell Reseearch
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2015-06-24 – 2015-06-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] NURR1 induction and functional analysis in dopaminergic progenitor cells2015

    • Author(s)
      Motono Makoto, Takahashi Jun
    • Organizer
      The 18th Takeda Science Foundation Symposium
    • Place of Presentation
      Center for Learning and Innovation Takeda Pharmaceutical Company Ltd.
    • Year and Date
      2015-01-15 – 2015-01-17
    • Related Report
      2014 Annual Research Report
  • [Remarks] 京都大学再生医科学研究所 再生医科学研究部門 生体修復応用分野

    • URL

      http://www.frontier.kyoto-u.ac.jp/ca01/index.html

    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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