In vivo optical imaging methods evaluating neurological diseases

• Project/Area Number: 24659651
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Cerebral neurosurgery
• Research Institution: Okayama University
• Principal Investigator: ABE Koji 岡山大学, 医歯(薬)学総合研究科, 教授 (20212540)
• Co-Investigator(Kenkyū-buntansha): IKEDA Yoshio 群馬大学, 医学研究科, 教授 (00282400)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: In vivo イメージング / 脳梗塞 / マトリックスメタロプロテアーゼ / 血栓溶解療法 / 出血性脳梗塞 / in vivo imaging / MCAO / 蛍光顕微鏡 / トランスジェニックマウス

Research Abstract

Matrix metalloproteinase in vivo optical imaging technique could provide a novel non-invasive and real-time detection method for acute ischemic injury, especially when tPA and free radical scavenger are used after a stroke.

Research Products

• [Journal Article] Reducing hemorrhagic complication by dabigatran via neurovascular protection after recanalization with tissue plasminogen activator in ischemic stroke of rat (2014)
  • Author(s): Kono S, Deguchi K, and Abe K
  • Journal Title: J Neurosci Res Volume: 92 Issue: 1 Pages: 46-53
  • DOI: 10.1002/jnr.23302
  • NAID: 120005468282
  • Peer Reviewed
• [Journal Article] Acceleration of TDP43 and FUS/TLS protein expressions in the preconditioned hippocampus following repeated transient ischemia. (2014)
  • Author(s): Sun M, Yamashita T, Shang J, Liu N, Deguchi K, Liu W, Ikeda Y, Feng J, Abe K.
  • Journal Title: J Neurosci Res. Volume: 92 Issue: 1 Pages: 54-63
  • DOI: 10.1002/jnr.23301
  • Peer Reviewed
• [Journal Article] Reducing hemorrhagic complication by dabigatran via neurovascular protection after recanalization with tissue plasminogen activator in ischemic stroke of rat. (2014)
  • Author(s): Kono S, Deguchi K, Omote Y, Yunoki T, Yamashita T, Kurata T, Ikeda Y, and Abe K
  • Journal Title: J Neurosci Res Volume: 92 Pages: 46-53
  • NAID: 120005468282
  • Peer Reviewed
• [Journal Article] In vivo optical imaging correlates with improvement of cerebral ischemia treated by intravenous bone marrow stromal cells (BMSCs) and edaravone (2013)
  • Author(s): Tian F, Yamashita T, Deguchi K, Omote Y, Kawai H, Ohta Y, Abe K
  • Journal Title: Neurol Res Volume: 35 Issue: 10 Pages: 1051-1058
  • DOI: 10.1179/1743132813y.0000000252
  • Peer Reviewed
• [Journal Article] Combination benefit of amlodipine plus atorvastatin treatment on carotid atherosclerosis in Zucker metabolic rats (2013)
  • Author(s): Kawai H, Kurata T, and Abe K
  • Journal Title: Neurol Res Volume: 35 Issue: 4 Pages: 181-186
  • DOI: 10.1007/s12975-012-0205-6
  • Peer Reviewed
• [Journal Article] Tissue Plasminogen Activator Thrombolytic Therapy for Acute Ischemic Stroke in 4 Hospital Groups in Japan. (2013)
  • Author(s): Kono S, Deguchi K, Morimoto N, Kurata T, Deguchi S, Yamashita T, Ikeda Y, Matsuura T, Narai H, Omori N, Manabe Y, Yunoki T, Takao Y, Kawata S, Kashihara K, Abe K.
  • Journal Title: J Stroke Cerebrovasc Dis Volume: 22 Issue: 3 Pages: 190-196
  • DOI: 10.1016/j.jstrokecerebrovasdis.2011.07.016
  • Peer Reviewed
• [Journal Article] Intravenous thrombolysis with neuroprotective therapy by edaravone for ischemic stroke patients older than 80 years of age (2013)
  • Author(s): Kono S, Deguchi K, and Abe K
  • Journal Title: J Stroke Cerebrovasc Dis Volume: 22 Issue: 7 Pages: 1175-1183
  • DOI: 10.1016/j.jstrokecerebrovasdis.2013.02.010
  • Peer Reviewed
• [Journal Article] Cerebral embolic stroke after disappearing takotsubo cardiomyopathy (2013)
  • Author(s): Matsuzono K, Ikeda Y, Deguchi S, and Abe K
  • Journal Title: J Stroke Cerebrovasc Dis Volume: 22 Pages: 682-683
  • Peer Reviewed
• [Journal Article] Synchronized Babinski and Chaddock signs preceded the MRI findings in a case of repetitive transient ischemic attack (2013)
  • Author(s): Matsuzono K, Yoshiki T, Ikeda Y, Abe K
  • Journal Title: Intern Med Volume: 52 Pages: 2127-2129
  • NAID: 130003365811
  • URL: https://www.jstage.jst.go.jp/article/internalmedicine/52/18/52_52.0190/_article
  • Peer Reviewed
• [Journal Article] Intravenous Tissue Plasminogen Activator Therapy for an Acute Ischemic Stroke Patient with Later Diagnosed Unilateral Moyamoya Syndrome (2013)
  • Author(s): Yokoyama S, Manabe Y, Fujii D, Ikeda-Sakai Y, Narai H, Omori N and Abe K
  • Journal Title: J Stroke Cerebrovasc Dis Volume: 22 Issue: 7 Pages: 1190-1192
  • DOI: 10.1016/j.jstrokecerebrovasdis.2012.06.011
  • Peer Reviewed
• [Journal Article] In vivo optical imaging correlates with improvement of cerebral ischemia treated by intravenous bone marrow stromal cells (BMSCs) and edaravone. (2013)
  • Author(s): Tian F, Yamashita T, Deguchi K, Omote Y, Kawai H, Ohta Y, Abe K
  • Journal Title: Neurol Res. Volume: 35 Pages: 1051-1058
  • Peer Reviewed
• [Journal Article] Synchronized Babinski and Chaddock signs preceded the MRI findings in a case of repetitive transient ischemic attack. (2013)
  • Author(s): Matsuzono K, Yoshiki T, Wakutani Y, Manabe Y, Yamashita T, Deguchi K, Ikeda Y, Abe K
  • Journal Title: Intern Med. Volume: 52 Pages: 2127-2129
  • NAID: 130003365811
  • Peer Reviewed
• [Journal Article] Cerebral embolic stroke after disappearing takotsubo cardiomyopathy. (2013)
  • Author(s): Matsuzono K, Ikeda Y, Deguchi S, Yamashita T, Kurata T, Deguchi K and Abe K
  • Journal Title: J Stroke Cerebrovasc Dis. Volume: 22 Pages: 682-683
  • Peer Reviewed
• [Journal Article] Intravenous thrombolysis with neuroprotective therapy by edaravone for ischemic stroke patients older than 80 years of age. (2013)
  • Author(s): Kono S, Deguchi K, Morimoto N, Kurata T, Yamashita T, Ikeda Y, Narai H, Manabe Y, Takao Y, Kawada S, Kashihara K, Takehisa Y, Inoue S, Kiriyama H, and Abe K
  • Journal Title: J Stroke Cerebrovasc Dis. Volume: 22 Pages: 1175-1183
  • Peer Reviewed
• [Journal Article] Tissue plasminogen activator thrombolytic therapy for acute ischemic stroke in 4 hospital groups in Japan. (2013)
  • Author(s): Kono S, Deguchi K, Morimoto N, Kurata T, Deguchi S, Yamashita T, Ikeda Y, Matsuura T, Narai H, Omori N, Manabe Y, Yunoki T, Takao Y, Kawata S, Kashihara K, and Abe K
  • Journal Title: J Stroke Cerebrovasc Dis. Volume: 22 Pages: 190-196
  • Peer Reviewed
• [Journal Article] Combination benefit of amlodipine plus atorvastatin treatment on carotid atherosclerosis in Zucker metabolic rats. (2013)
  • Author(s): Kawai H, Kurata T, Deguchi K, Deguchi S, Yamashita T, Ohta Y, Omote Y, Kono S, and Abe K
  • Journal Title: Neurol Res. Volume: 35 Pages: 181-186
  • Peer Reviewed
• [Journal Article] Intravenous Tissue Plasminogen Activator Therapy for an Acute Ischemic Stroke Patient with Later Diagnosed Unilateral Moyamoya Syndrome. (2013)
  • Author(s): Yokoyama S, Manabe Y, Fujii D, Ikeda-Sakai Y, Narai H, Omori N and Abe K
  • Journal Title: J Stroke Cerebrovasc Dis. Volume: 22 Pages: 1190-1192
  • Peer Reviewed
• [Journal Article] ペナンブラの治療 脳保護療法の有効性 (2013)
  • Author(s): 阿部康二
  • Journal Title: 分子脳血管病 Volume: 12 Pages: 3-4
• [Journal Article] 脳虚血の分子イメージング. (2013)
  • Author(s): 阿部康二
  • Journal Title: Thrombosis Medicine Volume: 3 Pages: 59-67
• [Journal Article] Intracereberal Transplantation of Bone Marrow Stromal Cells Ameliorates Tissue Plasminogen Activator-Induced Brain Damage After Cerebral Ischemia in Mice Detected by In Vivo and Ex Vivo Optical Imaging. (2012)
  • Author(s): Liu N, Deguchi K, Yamashita T, Liu W, Ikeda Y, and Abe K
  • Journal Title: J Neurosci Res. Volume: 90 Issue: 11 Pages: 2086-2093
  • DOI: 10.1002/jnr.23104
  • Peer Reviewed
• [Journal Article] Clinical and pathological improvement in stroke-prone spontaneous hypertensive rats related to the pleiotropic effect of cilostazol (2012)
  • Author(s): Omote Y, Deguchi K, Tian F, Kawai H, Kurata T, Yamashita T, Ohta Y, Abe K
  • Journal Title: Stroke Volume: 43 Issue: 6 Pages: 1639-1646
  • DOI: 10.1161/strokeaha.111.643098
  • NAID: 120005468281
  • Peer Reviewed
• [Journal Article] Mechanisms of endogenous endothelial repair in stroke. (2012)
  • Author(s): Yamashita T, Abe K
  • Journal Title: Current Pharmaceutical Design. Volume: 18 Pages: 279-285
  • Peer Reviewed
• [Journal Article] Effect of mitochondrial transcription factor a overexpression on motor neurons in amyotrophic lateral sclerosis model mice (2012)
  • Author(s): Morimoto, N., Miyazaki, K., Kurata, T., Ikeda, Y., Matsuura, T., Kang, D., Ide, T., Abe, K.
  • Journal Title: J Neurosci Res Volume: 90 Issue: 6 Pages: 1200-12008
  • DOI: 10.1002/jnr.23000
  • Peer Reviewed
• [Journal Article] Stem Cell Therapy for Cerebral Ischemia – From Basic Science to Clinical Applications – (2012)
  • Author(s): Abe K, Yamashita T, Takizawa S, Kuroda S, Kinouchi H, Kawahara N
  • Journal Title: J Cereb Blood Flow Metab. Volume: 32 Pages: 1317-1331
  • Peer Reviewed
• [Journal Article] Modifying neurorepair and neuroregenerative factors with tPA and edaravone after transient middle cerebral artery occlusion in rat brain. (2012)
  • Author(s): Deguchi K, Miyazaki K, Tian F, Liu N, Liu W, Kawai H, Omote Y, Kono S, Yunoki T, Deguchi S, Abe K.
  • Journal Title: Brain Res. Volume: 1436 Pages: 168-177
  • Peer Reviewed
• [Journal Article] Scheie Syndrome Diagnosed After Cerebral Infarction. (2012)
  • Author(s): Fujii D, Mnabe Y, Tanaka T, Kono S, Sakai Y, Narai H, Omori N, Furujyo M, Abe K
  • Journal Title: Journal of Stroke and Cerebrovascular Diseases Volume: 21 Pages: 330-332
  • Peer Reviewed
• [Journal Article] Strong neuroprotection with a novel platinum nanoparticle against ischemic stroke- and tissue plasminogen activator-related brain damages in mice. (2012)
  • Author(s): Takamiya M, Miyamoto Y, Yamashita T, Ohta Y, Deguchi K, and Abe K
  • Journal Title: Neuroscience Volume: 221 Pages: 47-55
  • Peer Reviewed
• [Presentation] Clinical and Pathological Improvement in Stroke-Prone Spontaneous Hypertensive Rats Associated with Pleiotropic Effect of Cilostazol (2013)
  • Author(s): Omote Y, Deguchi K, Kurata T, Yamashita T, Ikeda Y, and Abe K
  • Organizer: International TIA/ACVS Conference (TIA2013)
  • Place of Presentation: Tokyo, Japan
• [Presentation] Synergistic benefit of combined amlodipine plus atorvastatin on neuronal damage after stroke in Zucker metabolic rat (2013)
  • Author(s): Omote Y, Kawai H, Deguchi K, Yamashita T, Kurata T, and Abe K
  • Organizer: International TIA/ACVS Conference (TIA2013)
  • Place of Presentation: Tokyo, Japan
• [Presentation] A case of recurrent vasospasm of the cervical ICA (2013)
  • Author(s): Sato K, Omote Y, Nakano Y, Takamiya M, Yamashita T, Kurata T, Deguchi K, and Abe K
  • Organizer: International TIA/ACVS Conference (TIA2013)
  • Place of Presentation: Tokyo, Japan
• [Presentation] Neuroprotective Therapy by Edaravone with Intravenous tPA for Acute Ischemic Stroke in the Elderly Patients (2013)
  • Author(s): Kono S, Deguchi K, Yamashita T, Manabe Y, Takao Y, Kashihara K, Inoue S, Kiriyama H, and Abe K
  • Organizer: The 6th Korea-Japan Joint Stroke Conference
  • Place of Presentation: Osaka, Japan
• [Presentation] Intravenous Thrombolysis with Neuroprotective Therapy by Edaravone for Ischemic Stroke Patients Older than 80 Years of Age (2013)
  • Author(s): Kono S, Deguchi K, Yamashita T, Manabe Y, Takao Y, Kashihara K, Inoue S, Kiriyama H, and Abe K
  • Organizer: Asia Pacific Stroke Conference 2013
  • Place of Presentation: Hong Kong, China
• [Presentation] Prospective surveillance data of human prion disease in Chugoku and Shikoku region in Japan (2013)
  • Author(s): Sato K, Abe K
  • Organizer: The 20th IAGG World Congress of the International Association of Gerontology and Geriatrics
  • Place of Presentation: Soeul, Korea
• [Presentation] Modifying neurorepair and neuroregenerative factors with tPA and edaravone after transient middle cerebral artery occlusion in rat brain (2013)
  • Author(s): Deguchi K, Liu N, Liu W, Omote Y, Kono S, Yunoki T, Deguchi S, Yamashita T, and Abe K
  • Organizer: Brain 2013
  • Place of Presentation: Shanghai, China
• [Presentation] Direct reprogramming from human fibroblasts to hiN cells; A novel method preparing cell resource for stroke therapy (2013)
  • Author(s): Yamashita T, Abeliovich A, and Abe K
  • Organizer: Brain 2013
  • Place of Presentation: Shanghai, China
• [Presentation] tPA thrombolytic therapy for acute ischemic stroke in 4 hospital groups of Japan (2013)
  • Author(s): Kono S, Deguchi K, Morimoto N, Kurata T, Yamashita T, Manabe Y, Takao Y, Kashihara K, and Abe K
  • Organizer: Brain 2013
  • Place of Presentation: Shanghai, China
• [Presentation] Clinical and Pathological Improvement in Stroke-Prone Spontaneous Hypertensive Rats Related to Pleiotropic Effect of Cilostazol (2013)
  • Author(s): Omote Y, Deguchi K, Tian F, Kawai H, Kurata T, Yamashita T, Ohta Y, Abe K
  • Organizer: Internationa Stroke Conference
  • Place of Presentation: Honolulu, Hawaii, USA
• [Presentation] Modifying neurorepair and neuroregenerative factors with tPA and edaravone after transient middle cerebral artery occlusion in rat brain. (2013)
  • Author(s): Deguchi K, Liu N, Liu W, Omote Y, Kono S, Yunoki T, Deguchi S, Yamashita T, and Abe K
  • Organizer: Brain 2013
  • Place of Presentation: Shanghai, China
• [Presentation] Direct reprogramming from human fibroblasts to hiN cells; A novel method preparing cell resource for stroke therapy. (2013)
  • Author(s): Yamashita T, Abeliovich A, and Abe K
  • Organizer: Brain 2013
  • Place of Presentation: Shanghai, China
• [Presentation] tPA thrombolytic therapy for acute ischemic stroke in 4 hospital groups of Japan. (2013)
  • Author(s): Kono S, Deguchi K, Morimoto N, Kurata T, Yamashita T, Manabe Y, Takao Y, Kashihara K, and Abe K
  • Organizer: Brain 2013
  • Place of Presentation: Shanghai, China
• [Presentation] Neuroprotective Therapy by Edaravone with Intravenous tPA for Acute Ischemic Stroke in the Elderly Patients. (2013)
  • Author(s): Kono S, Deguchi K, Yamashita T, Manabe Y, Takao Y, Kashihara K, Inoue S, Kiriyama H, and Abe K
  • Organizer: The 6th Korea-Japan Joint Stroke Conference
  • Place of Presentation: Osaka, Japan
• [Presentation] Synergistic benefit of combined amlodipine plus atorvastatin on neuronal damage after stroke in Zucker metabolic rat. (2013)
  • Author(s): Omote Y, Kawai H, Deguchi K, Yamashita T, Kurata T, and Abe K
  • Organizer: International TIA/ACVS Conference (TIA2013)
  • Place of Presentation: Tokyo, Japan
• [Presentation] In Vivo Optical Imaging for Evaluating the Efficacy of Edaravone after Transient Cerebral Ischemia in Mice . (2012)
  • Author(s): Liu N, Shang J, Nishi H and Abe K
  • Organizer: 2nd International Neural Regeneration Symposium
  • Place of Presentation: Shenyang, China
• [Presentation] Modifying neurorepair and neuroregenerative factors with tPA and edaravone after transient middle cerebral artery occlusion in rat brain (2012)
  • Author(s): Deguchi K, Tian F, Liu N, Liu W, Omote Y, Kono S, Yunoki T, Deguchi S, Abe K
  • Organizer: 8th WORLD STROKE CONGRESS
  • Place of Presentation: Brasilia, Brazil
• [Presentation] Intracerebral transplantation of bone marrow stromal cells ameliorates tissue plasminogen activator-induced brain damage after cerebral ischemia in mice detected by in vivo and ex vivo optical imaging. (2012)
  • Author(s): Liu N, Deguchi K, Yamashita T, Liu W, Ikeda Y, Abe K
  • Organizer: 第7回日本分子イメージング学会学術集会
  • Place of Presentation: 浜松
• [Presentation] 脳卒中易発症高血圧ラット（SHR-SP）におけるシロスタゾールの多面的効果の検討． (2012)
  • Author(s): 表 芳夫、出口健太郎、田 豊豊、河相裕美、倉田智子、山下 徹、太田康之、阿部康二
  • Organizer: 第65回日本酸化ストレス学会
  • Place of Presentation: 徳島
• [Book] Edaravone therapy : From bench to bedside:Oxidative Stress in Applied Basic Research and Clinical Practice - Pediatric Disorders (2013)
  • Author(s): Yamashita T, and Abe K
  • Publisher: Springer
• [Book] Cerebro-Spinal Blood Flow and its Regulation : Nuroanesthesia and Cerebro-Spinal Protection (2013)
  • Author(s): Yamashita T, Miyazaki K, and Abe K
  • Publisher: Springer
• [Book] Research and Clinical Practice - Pediatric Disorders; Edaravone therapy: From bench to bedside： Oxidative Stress in Applied Basic (2013)
  • Author(s): Yamashita T, and Abe K
  • Total Pages: 8
  • Publisher: Springer
• [Book] n:Nuroanesthesia and Cerebro-Spinal Protection; Cerebro-Spinal Blood Flow and its Regulatio (2013)
  • Author(s): Yamashita T, and Abe K
  • Total Pages: 7
  • Publisher: Springer
• [Book] TREATMENT OF DAMAGED BRAIN FOLLOWING A STROKE： NEW STRATEGIES, STEM CELLS AND CANCER STEM CELLS; (2012)
  • Author(s): Yamashita T, Abe K
  • Total Pages: 12
  • Publisher: Springer